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The formation of charged pion condensate in anti-parallel electromagnetic fields and in the presence of the isospin chemical potential is studied in the two-flavor Nambu-Jona-Lasinio model.The method of Schwinger proper time is extended to explore the quantities in the off-diagonal flavor space,i.e.the charged pion.In this framework,π^± are treated as bound states of quarks and not as point-like charged particles.The isospin chemical potential plays the role of a trigger for charged pion condensation.We obtain the associated effective potential as a function of the strength of the electromagnetic fields and find that it contains a sextic term which possibly induces a weak first order phase transition.The dependence of pion condensation on model parameters is investigated. 相似文献
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A systematic study of glycopeptide esterification for the semi‐quantitative determination of sialylation in antibodies 下载免费PDF全文
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Sergey A. Nazarov Andrey S. Slutskij Jari Taskinen 《Mathematical Methods in the Applied Sciences》2014,37(16):2463-2483
We consider an elastic rod with rounded ends and diameter proportional to a small parameter h > 0. The roundness of the ends is described by an exponent m ∈ (0,1). We derive for the rod an asymptotically sharp Korn inequality with a special weighted anisotropic norm. Weight factors with m‐dependent powers of h appear both in the anisotropic norm and the Korn inequality itself, and we discover three critical values m = 1 ∕ 4, m = 1 ∕ 2 and m = 3 ∕ 4 at which these exponents are crucially changed. Copyright © 2014 John Wiley & Sons, Ltd. 相似文献
96.
Dr. Vadim B. Krylov Dr. Alexey G. Gerbst Dmitry A. Argunov Dr. Andrey S. Dmitrenok Prof. Dr. Alexander S. Shashkov Prof. Dr. Zbigniew Kaczynski Prof. Dr. Johannes Huebner Prof. Dr. Otto Holst Prof. Dr. Nikolay E. Nifantiev 《Chemistry (Weinheim an der Bergstrasse, Germany)》2015,21(4):1749-1754
Enterococcus faecalis is one of most important nosocomial and often multi‐antibiotic resistant pathogens responsible for infections that are difficult to treat. Previously, a cell‐wall polysaccharide termed diheteroglycan (DHG) was isolated and characterized as a promising vaccine candidate. However, the configuration of its lactic acid (LA) residue attached to the galactofuranoside unit was not assessed, although it influences conformation of DHG chain in terms of biological recognition and immune evasion. This study proves the R configuration of the LA residue by means of chemical analysis, investigation of intramolecular NMR nuclear Overhauser effects and molecular dynamics simulations of native DHG and corresponding R and S models, which were obtained by using pyranoside‐into‐furanoside rearrangement. As alternative treatment and prevention strategies for E. faecalis are desperately needed, this discovery may offer the prospect of a synthetic vaccine to actively immunize patients at risk. 相似文献
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Nanofluidics encompasses a wide range of advanced approaches to study charge and mass transport at the nanoscale. Modern technologies allow us to develop and improve artificial nanofluidic platforms that confine ions in a way similar to single-ion channels in living cells. Therefore, nanofluidic platforms show great potential to act as a test field for theoretical models. This review aims to highlight ionic Coulomb blockade (ICB)—an effect that is proposed to be the key player of ion channel selectivity, which is based upon electrostatic exclusion limiting ion transport. Thus, in this perspective, we focus on the most promising approaches that have been reported on the subject. We consider ion confinements of various dimensionalities and highlight the most recent advancements in the field. Furthermore, we concentrate on the most critical obstacles associated with these studies and suggest possible solutions to advance the field further. 相似文献
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Dzmitry Padhorny David R. Hall Hanieh Mirzaei Artem B. Mamonov Mohammad Moghadasi Andrey Alekseenko Dmitri Beglov Dima Kozakov 《Journal of computer-aided molecular design》2018,32(1):225-230
Fast Fourier transform (FFT) based approaches have been successful in application to modeling of relatively rigid protein–protein complexes. Recently, we have been able to adapt the FFT methodology to treatment of flexible protein–peptide interactions. Here, we report our latest attempt to expand the capabilities of the FFT approach to treatment of flexible protein–ligand interactions in application to the D3R PL-2016-1 challenge. Based on the D3R assessment, our FFT approach in conjunction with Monte Carlo minimization off-grid refinement was among the top performing methods in the challenge. The potential advantage of our method is its ability to globally sample the protein–ligand interaction landscape, which will be explored in further applications. 相似文献
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