Convenient synthesis of some optically active 1,4-benzodiazepin-2,5-diones

Isatoic anhydride was reacted with several L-amino acids to give the corresponding （2S）-N-（o-aminobenzoyl）-2-alkylaminoacetic acids. The latter compounds were treated with phosphoryl chloride under reflux temperature to afford the cyclized products, （3S）-3-alkyl-3,4-dihydro- 1 H- 1,4-benzodiazepin-2,5-diones. 2007 M. Bakavoli. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.     

Solution thermodynamics and preferential solvation of triclocarban in {1,4-dioxane (1) + water (2)} mixtures at 298.15 K

The equilibrium solubility and preferential solvation of triclocarban in {1,4-dioxane (1) + water (2)} mixtures at 298.15 K was reported. Mole fraction solubility varies continuously from 2.85 × 10^–9 in neat water to 2.39 × 10^–3 in neat 1,4-dioxane. Solubility behaviour was adequately correlated by means of the Jouyban-Acree model. Based on the inverse Kirkwood-Buff integrals, preferential solvation parameters were calculated. Triclocarban is preferentially solvated by water in water-rich mixtures (0.00 < x₁ < 0.18) and also in 1,4-dioxane-rich mixtures (0.78 < x₁ < 1.00) but preferentially solvated by 1,4-dioxane in mixtures with similar solvent compositions.     

Equilibrium solubility,preferential solvation and apparent specific volume of sucrose in some {cosolvent (1) + water (2)} mixtures at 298.2 K

Sucrose is the most widely used sweetener in food and pharmaceuticals. Solubility data of this excipient in aqueous cosolvent mixtures is not abundant. Thus, the main objective of this research was to determine and correlate the equilibrium solubility of sucrose in some {cosolvent (1) + water (2)} mixtures at 298.2 K. Cosolvents were ethanol, propylene glycol and glycerol. Shaken flask method was used to determine isothermal solubility. Concentration measurements were performed by means of density determinations. Solubility of sucrose decreases non-linearly with the addition of cosolvent to water. By means of the inverse Kirkwood–Buff method it is shown that sucrose is preferentially solvated by cosolvent in water-rich mixtures but preferentially solvated by water in cosolvent-rich mixtures. Jouyban–Acree model correlates solubility values with the mixtures composition for all cosolvent systems. Moreover, apparent specific volume of sucrose was also calculated from density and compositions.     

Comments concerning “Study of solute–solvent and solvent–solvent interactions in pure and mixed binary solvents”

A number of mathematical equations representing the solute solubility in monosolvent and binary solvent mixtures are discussed. This work is a commentary to the article of Maitra and Baghchi that appeared in this journal.     

Computational Study of Regioselective Synthesis of Triflylpyrazole by Cycloaddition Reaction between Diphenyl Hydrazonoyl Chloride and Phenyl Triflyl Acetylene

The mechanism and regioselectivity of cycloaddition reaction between diphenyl hydrazonoyl chloride and phenyl triflyl acetylene as an electron-deficient dipolarophyl in acetonitrile at room temperature are theoretically investigated using density functional theory and solvent polarized continuum model. Two general mechanism, concerted and stepwise mechanism, have been proposed for this reaction. Each mechanism has two different paths and two possible products. The activation energies of pathways were calculated using quantum mechanical approach and compared with each other. An excellent agreement was observed between the previously reported experimental work and the theoretical approaches for regioselectivity of this reaction.     

Another application of (NH4)42[MoVI72MoV60O372(CH3COO)30(H2O)72] as a highly efficient recyclable catalyst for the synthesis of dihydropyrano[3,2‐c]chromenes

In continuation of our previous works on the application of (NH₄)₄₂[Mo^VI₇₂Mo^V₆₀O₃₇₂(CH₃COO)₃₀(H₂O)₇₂], a Keplerate‐type giant‐ball nanoporous isopolyoxomolybdate, as a catalyst for the synthesis of heterocyclic compounds, in this paper, we report another application of this attractive catalyst in the synthesis of 2‐amino‐5‐oxo‐4,5‐dihydropyrano[3,2‐c]chromene‐3‐carbonitriles via a one‐pot three‐component reaction of 4‐hydroxycoumarin, aldehydes and malononitrile. The reactions occur in ethanol–water as solvent at room temperature and the process is operative with various aldehydes, giving the corresponding products in high yields. Other beneficial features of this protocol include short reaction times, simple work‐up and the recyclability and reusability of the catalyst for up to five consecutive runs. Copyright © 2016 John Wiley & Sons, Ltd.     

A comparative study of TiO2, Al2O3, and Fe3O4 nanoparticles as reusable heterogeneous catalysts in the synthesis of tetrahydrobenzo[a]xanthene-11-ones

Russian Journal of General Chemistry - Catalytic effect of three nanosized metal oxides TiO2, Al2O3 and Fe3O4 nanoparticles in the onepot synthesis of tetrahydrobenzo[a]xanthene-11-ones by...     

Regioselective synthesis of (E)-3-[2-(arylmethylene)-1-(arylsulfonyl)hydrazino]-2-propenoates via the reaction of arylsulfonyl hydrazones and alkyl propiolates in the presence of triphenylphosphine

A regioselective method for the synthesis of (E)-3-[2-(arylmethylene)-1-(arylsulfonyl)hydrazino]-2-propenoates is described. The reaction takes place between arylsulfonyl hydrazones and alkyl propiolates in the presence of triphenylphosphine as the catalyst.