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1.
I. V. Ukrainets L. V. Sidorenko O. V. Gorokhova O. V. Shishkin A. V. Turov 《Chemistry of Heterocyclic Compounds》2006,42(9):1208-1222
The reaction of 6-fluoro-2-methyl-1,2,3,4-tetrahydroquinoline with triethylmethanetricarboxylate gives di(9-fluoro-1-hydroxy-5-methyl-3-oxo-6,7-dihydro-3H,5H-pyrido[3,2,1-ij]quinolin-2-yl)methane
and ethyl 9-fluoro-1-hydroxy-5-methyl-3-oxo-6,7-dihydro-3H,5H-pyrido[3,2,1-ij]quinoline-2-carboxylate from which alkyl-, dialkylaminoalkyl-,
and hetarylamides as well as hydrazides were prepared. The structure and antitubercular properties of the compounds synthesized
are discussed.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 9, pp. 1391–1407, September, 2006. 相似文献
2.
I. V. Ukrainets A. A. Tkach E. V. Mospanova E. N. Svechnikova 《Chemistry of Heterocyclic Compounds》2007,43(8):1014-1019
A preparative method has been developed for the synthesis of 1-hydroxy-3-oxo-5,6-dihydro-3H pyrrolo[3,2,1-ij]quinoline-2-carboxylic
acid hydrazide and its derivatives. The results of a study of the antitubercular activity of the synthesized compounds are
presented.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 8, pp. 1196–1203, August, 2007. 相似文献
3.
I. V. Ukrainets E. V. Mospanova L. V. Sidorenko 《Chemistry of Heterocyclic Compounds》2007,43(7):863-870
An improved method is reported for the synthesis of a series of 1-hydroxy-3-oxo-5,6-dihydro-3H-pyrrolo[3,2,1-ij]quinoline-2-carboxylic
acid hetarylamides. The antitubercular activity of all of the compounds prepared has been studied. The structure-biological
activity dependence revealed is discussed.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 7, pp. 1023–1033, July, 2007. 相似文献
4.
I. V. Ukrainets N. Yu. Golik K. V. Andreeva O. V. Gorokhova 《Chemistry of Heterocyclic Compounds》2011,46(12):1459-1466
Modified methods are proposed for the preparation of the ethyl ester and alkylamides of 1-hydroxy-3-oxo-6,7-dihydro-3H,5H-pyrido[3,2,1-ij]quinoline-2-carboxylic acid. A comparative analysis has been carried out of the steric structure and diuretic activity of
the synthesized compounds and the previously studied, and closely structurally related, 1-hydroxy-3-oxo-5,6-dihydro-3H-pyrrolo-[3,2,1-ij]quinoline-2-carboxamides. 相似文献
5.
I. V. Ukrainets E. V. Mospanova N. L. Bereznyakova O. I. Naboka 《Chemistry of Heterocyclic Compounds》2007,43(12):1532-1539
Two methods are discussed and the synthesis of a series of 1-hydroxy-3-oxo-5,6-dihydro-3H-pyrrolo[3,2,1-ij]quinoline-2-carboxylic
acid anilides has been carried out. The antitubercular activity and the effect on the urinary function of the kidney have
been studied for the compounds prepared. A structure-biological activity relationship is discussed.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 12, pp. 1808–1819, December, 2007. 相似文献
6.
H Ishikawa T Uno H Miyamoto H Ueda H Tamaoka M Tominaga K Nakagawa 《Chemical & pharmaceutical bulletin》1990,38(9):2459-2462
A series of substituted 1,2-dihydro-6-oxo-pyrrolo[3,2,1-ij]quinoline-5-carboxylic acids for the treatment of systemic infections was synthesized via 7-bromo-3-ethylthio-4,5-difluoro-2-methylindole (3), which was prepared by Gassman's indole synthesis in excellent yield. The synthesized pyrroloquinolines were tested for their antibacterial activities. 8-Fluoro-1,2-dihydro-2-methyl-9-(4-methyl-1-piperazinyl)-6-oxo-6H- pyrrolo[3,2,1-ij]quinoline-5-carboxylic acid showed a potent antibacterial activity against gram-positive and gram-negative bacteria. 相似文献
7.
I. V. Ukrainets N. L. Bereznyakova E. V. Mospanova 《Chemistry of Heterocyclic Compounds》2007,43(7):856-862
A simple method is proposed for preparing 1-hydroxy-3-oxo-5,6-dihydro-3H-pyrrolo[3,2,1-ij]-quinoline-2-carboxylic acid alkylamides.
For the case of the secondary butylamide features of the steric structure of the synthesized compounds is discussed. The results
of a study of their anti-inflammatory and diuretic activities are presented.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 7, pp. 1015–1022, July, 2007. 相似文献
8.
I. V. Ukrainets N. Yu. Golik A. L. Shemchuk V. N. Kravchenko 《Chemistry of Heterocyclic Compounds》2011,47(9):1122-1127
Hydroxy- and alkoxyanilides of 6-hydroxy-2-methyl-4-oxo-2,4-dihydro-1H-pyrrolo[3,2,1-ij]quinoline-5-carboxylic acids have been synthesized as potential diuretic agents. Features of their purification, their steric
structure, and biological activity are discussed. 相似文献
9.
I. V. Ukrainets O. V. Gorokhova L. V. Sidorenko N. L. Bereznyakova 《Chemistry of Heterocyclic Compounds》2006,42(8):1032-1037
The first stage of the reaction of triethyl methanetricarboxylate with indoline is the formation of the diethyl ester of 2-(indoline-1-carbonyl)malonic
acid, which then, depending on the conditions selected, may be converted into the ethyl ester of 2-(indoline-1-carbonyl)-3-(indolin-1-yl)-3-oxopropionic
acid, methanetri-N-(indolin-1-yl)carboxamide, or the ethyl ester or (indolin-1-yl)amide of 1-hydroxy-3-oxo-5,6-dihydro-3H-pyrrolo[3,2,1-ij]quinoline-2-carboxylic
acid.
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Translated From Khimiya Geterotsiklicheskikh Soedinenii, No. 8, pp. 1191–1197, August, 2006. 相似文献
10.
S. M. Medvedeva E. V. Leshcheva Kh. S. Shikhaliev A. S. Solov’ev 《Chemistry of Heterocyclic Compounds》2006,42(4):534-539
Based on the reaction of 8-R-4,5-dihydro-4,4-dimethyl[1,2]dithiolo[3,4-c]quinoline-1-thiones with oxalyl chloride followed
by the reactions of 1,3-dipolar cycloaddition and diene synthesis with participation of acetylenedicarboxylic acid dimethyl
ester, we have developed approaches to synthesis of novel polycondensed heterocyclic systems: [1,2]dithiolo[3,4-c]pyrrolo[3,2,1-ij]quinoline-4,5-dione,
6-(1,3-dithiol-2-ylidene)-1,2-dioxo-5-thioxo-7H-pyrrolo[3,2,1-ij]quinoline and 4,5-dioxospiro(pyrrolo)-[3,2,1-ij]thiopyrano[2,3-c]quinoline-11,2′-[1,3]dithiole.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 4, pp. 610–615, April, 2006. 相似文献
11.
I. V. Ukrainets L. V. Sidorenko O. V. Gorokhova E. V. Mospanova O. V. Shishkin 《Chemistry of Heterocyclic Compounds》2006,42(5):631-635
A modified method is proposed for preparation and purification, and the special features of the spatial structure have been
studied for the ethyl ester of 1-hydroxy-3-oxo-5,6-dihydro-3H-pyrrolo[3,2,1-i,j]-quinoline-2-carboxylic acid.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 5, pp. 718–723, May, 2006. 相似文献
12.
I. V. Ukrainets A. A. Tkach L. A. Grinevich A. V. Turov O. V. Bevz 《Chemistry of Heterocyclic Compounds》2009,45(5):567-579
The synthesis of a series of 1-R-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxylic acids pyrimidin-2-ylamides has been carried
out with the aim of subsequent microbiological investigation. In acetic acid it was found that these compounds are brominated
by 1 equivalent of bromine at position 5 of the pyrimidine ring. The only exception is the 1-allyl derivative which undergoes
heterocyclization under these conditions to give 2-bromomethyl-5-oxo-1,2-dihydro-5H-oxazolo[3,2-a]quinoline-4-carboxylic acid
pyrimidin-2-ylamide. The results of a study of the antitubercular activity of the synthesized compounds are presented. 相似文献
13.
I. V. Ukrainets R. G. Red’kin L. V. Sidorenko A. V. Turov 《Chemistry of Heterocyclic Compounds》2009,45(12):1478-1484
A three-component condensation of 1-allyl-4-hydroxy-2-oxo-1,2-dihydroquinoline, isatin, and malononitrile gave a satisfactory
yield of 4,3'-spiro[(6-allyl-2-amino-5-oxo-5,6-dihydro-4H-pyrano-[3,2-c]quinoline-3-carbonitrile)-2'-oxindole], which structure
was confirmed by X-ray analysis. 相似文献
14.
Novichikhina N. P. Shestakov A. S. Potapov A. Yu. Kosheleva E. A. Shatalov G. V. Verezhnikov V. N. Vandyshev D. Yu. Ledeneva I. V. Shikhaliev Kh. S. 《Russian Chemical Bulletin》2020,69(4):787-792
Russian Chemical Bulletin - Hybrid compounds based on 4,4,6-trimethyl-4H-pyrrolo[3,2,1-ij]quinoline-1,2-diones containing a piperazine fragment were synthesized. Their inhibitory activity against... 相似文献
15.
Novichikhina N. P. Skoptsova A. A. Shestakov A. S. Potapov A. Yu. Kosheleva E. A. Kozaderov O. A. Ledenyova I. V. Podoplelova N. A. Panteleev M. A. Shikhaliev Kh. S. 《Russian Journal of Organic Chemistry》2020,56(9):1550-1556
Russian Journal of Organic Chemistry - The reaction of pyrrolo[3,2,1-ij]quinoline-1,2-diones with methyl (het)aryl ketones gave the corresponding 1-(het)arylmethylidenepyrroloquinolin-2-ones, and... 相似文献
16.
I. V. Ukrainets L. A. Grinevich A. A. Tkach O. V. Bevz S. V. Slobodzian 《Chemistry of Heterocyclic Compounds》2009,45(9):1058-1068
1-R-4-Hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxylic acid pyrazin-2-ylamides have been synthesized as potential antitubercular
agents. In contrast to pyrimidin-2-ylamides the compounds prepared are brominated by molecular bromine in glacial acetic acid
at position 6 of the quinolone ring rather than in the amide part of the molecule. The 1-N-allyl derivative behaves similarly
but undergoes halocyclization to give 2-bromomethyl-5-oxo-1,2-dihydro-5H-oxazolo[3,2-a]quinoline-4-carboxylic acid pyrazin-2-ylamide. A comparative analysis of the antimycobacterial properties of the synthesized
compounds and their isomeric pyrimidin-2-ylamides has been carried out. 相似文献
17.
I. V. Ukrainets L. V. Sidorenko O. V. Gorokhova S. V. Slobodzyan 《Chemistry of Heterocyclic Compounds》2007,43(1):63-66
The reaction of 2-ethoxycarbonylmethyl-4H-3,1-benzoxazin-4-one with malononitrile in dry pyridine leads to 1-hydroxy-3,6-dioxo-4,6-dihydro-3H-pyrimido[1,2-a]quinoline-5-carbonitrile.
Acetoacetic and cyanoacetic esters under analogous conditions form anilides of 4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxylic
acid while diethyl malonate gives N,N′-di-2-carboxyanilides of malonic acid.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 1, pp. 75–79, January, 2007. 相似文献
18.
I. V. Ukrainets L. V. Sidorenko O. S. Golovchenko 《Chemistry of Heterocyclic Compounds》2007,43(11):1434-1439
1-R-4-Hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxylic acids 2-nitrobenzylidenehydrazides are reduced to the corresponding
quinoline-3-carboxamides by zinc in glacial acetic acid but in refluxing triethylphosphite they are converted to the symmetrical
N,N′-di(4-hydroxy-2-oxo-1,2-dihydro-3-quinolinoyl)hydrazines. A study of the antitubercular activity of the synthetic compounds
has been carried out.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 11, pp. 1687–1692, November, 2007. 相似文献
19.
I. V. Ukrainets E. V. Mospanova A. A. Davidenko S. V. Shishkina 《Chemistry of Heterocyclic Compounds》2010,46(9):1084-1095
A targeted synthesis was carried out of a series of 1-allyl-4-hydroxy-6,7-dimethoxy-2-oxo-1,2-di-hydroquinoline-3-carboxylic
acid alkylamides which show interest for biological study as potential analgesics. It was found that, in the presence of one
equivalent of bromine, the compounds indicated undergo halocyclization to the corresponding 2-bromomethyl-7,8-dimethoxy-5-oxo-1,2-dihydro-5H-oxa-zolo[3,2-a]quinoline-4-carboxylic
acid alkylamides. However, with an excess of bromine the reaction occurs somewhat differently and concludes with the formation
of complexes of bromine with 4-alkyl-carbamoyl-2-bromomethyl-5-hydroxy-7,8-dimethoxy-1,2-dihydrooxazolo[3,2-a]quinolinium
ditri- bromides. According to the results of pharmacological screening there are found compounds within the substances discovered
with high analgesic activity. 相似文献
20.
Layek M Reddy M A Rao AV Alvala M Arunasree MK Islam A Mukkanti K Iqbal J Pal M 《Organic & biomolecular chemistry》2011,9(4):1004-1007
A facile two-step method for the construction of fused pyrrole ring leading to 5-substituted 2,3-dihydro-1H-pyrrolo[3,2,1-ij]quinolin-1-ones via C-C followed by intramolecular C-N bond forming reaction is described. In vitro pharmacological evaluation and molecular modelling studies of some of the compounds synthesized are presented. 相似文献