4-Hydroxy-2-quinolones. 108. N-R-amides of 9-fluoro-1-hydroxy-5-methyl-3-oxo-6,7-dihydro-3H,5H-pyrido[3,2,1-ij]quinoline-2-carboxylic acid and their antitubercular activity |
| |
| Authors: | I V Ukrainets L V Sidorenko O V Gorokhova O V Shishkin A V Turov |
| |
| Institution: | (1) National Pharmaceutical University, Kharkiv, 61002, Ukraine;(2) Institute of Scintillation Materials, Ukraine National Academy of Sciences, Kharkiv, 61001;(3) Taras Shevchenko National University, Kiev, 01033, Ukraine |
| |
| Abstract: | The reaction of 6-fluoro-2-methyl-1,2,3,4-tetrahydroquinoline with triethylmethanetricarboxylate gives di(9-fluoro-1-hydroxy-5-methyl-3-oxo-6,7-dihydro-3H,5H-pyrido3,2,1-ij]quinolin-2-yl)methane
and ethyl 9-fluoro-1-hydroxy-5-methyl-3-oxo-6,7-dihydro-3H,5H-pyrido3,2,1-ij]quinoline-2-carboxylate from which alkyl-, dialkylaminoalkyl-,
and hetarylamides as well as hydrazides were prepared. The structure and antitubercular properties of the compounds synthesized
are discussed.
__________
Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 9, pp. 1391–1407, September, 2006. |
| |
| Keywords: | heterocyclic tricarbonylmethanes 4-hydroxy-2-oxo-1 2-dihydroquinoline-3-carboxylic acid esters and amides antitubercular activity X-ray structural analysis |
| 本文献已被 SpringerLink 等数据库收录！ |
|
