共查询到20条相似文献,搜索用时 78 毫秒
1.
在离子液体和氟化钾反应体系中,研究了卤代哒嗪化合物的氟代反应,讨论了微波辐射条件下由卤代哒嗪化合物合成氟代哒嗪化合物的方法。用离子液体作为反应介质替代了传统的分子溶剂,提高了产物收率,简化了操作。用微波反应不仅获得了较好的收率,也缩短了反应时间。利用离子液体和微波辐射条件进行氟代反应是一种绿色化学方法。 相似文献
2.
3.
4.
5.
6.
刘开建 《高等学校化学学报》2014,(6):1236-1240
发展了一种简单、高效、温和的卤代炔烃水合反应体系.在阳离子金催化剂的催化作用下,以二氯乙烷为溶剂,室温下卤代炔烃发生水合反应,高收率、高区域选择性地得到单一的α-卤代甲基酮化合物(收率≥91%).该方法具有底物适用范围广、反应条件温和和环境友好等优点,为含α-卤代甲基酮结构单元的天然产物及复杂药物分子的合成提供了新方法. 相似文献
7.
在催化剂的作用下,通过芳香卤代化合物的双羰基化反应,一步直接生成α-酮酰胺 是近年来有机过渡金属化学方面新发现的反应之一。在三乙胺或乙酸钾的存在下,芳香卤代化合物、醇与一氧化碳在催化剂的作用下起双羰基化反应,一步生成酯和α-酮酯 相似文献
8.
9.
10.
11.
本文报导了与硅原子直接相连的有机基团(R)对杂氮硅三环成环速率的影响。利用气相色谱检测成环反应的产物之一——乙醇的生成速率和数量,并同与硅相连的R基团对成环反应速率的影响作比较。实验结果表明五种杂氮硅三环成环速度顺序为Cl_2CH—>ClCH_2—>ClCH_2CH_2CH_2—>CH_2=CH—>CH_3—,这与理论推断相符。 相似文献
12.
Eugenia Josefina Aldeco-Pérez Alfredo Toscano José Guillermo Penieres-Carrillo 《Tetrahedron letters》2008,49(18):2942-2945
The acid catalyzed reactions of three arylhydrazines with 4-phenyl-3-butynone in order to obtain the corresponding arylhydrazone were realized. The arylhydrazone reaction and an unexpected alkyne hydration reaction product were obtained when diphenylhydrazine was used. This product was identified by spectroscopic methods and X-ray diffractogram. A reaction mechanism is proposed for its formation. 相似文献
13.
Kazuma Matsuura Jun-ichi Nishida Takaaki Ito Ruri Yokota Chitoshi Kitamura Takeshi Kawase 《Tetrahedron》2019,75(2):278-285
Acenaphthylene units work as a useful platform for the synthesis of polycyclic aromatic hydrocarbons (PAH). Three 1,2-diarylacenaphthylene derivatives (9-phenanthryl, 7-t-butyl-2-pyrenyl and 2-naphthyl) were prepared by Suzuki-Miyaura coupling of 1,2-dibromoacenaphthylene with the corresponding boronic acids and ester. The Scholl reaction of the phenanthryl derivative affords a donor-acceptor type fluoranthene derivative possessing a hemi-coronene structure by forming two CC bonds between phenanthryl groups. The reaction of the pyrenyl derivative allows one CC bond formation to give a helicene-type fluoranthene derivative. The reaction of the naphthyl derivative provides an asymmetric fluroranthene derivative having an anthracene unit accompanied with one CC bonding reaction, while a photochemical cyclization followed by dehydroaromatization reaction of the compound gives a symmetric fluoranthene derivative with a [5]helicene structure. 相似文献
14.
Naoyoshi Maezaki 《Tetrahedron》2006,62(44):10361-10378
Highly stereoselective synthesis of 1,4-bifunctional compounds was accomplished via 1,2-asymmetric induction to α-oxyaldehyde and α-oxyketone followed by regio- and diastereoselective Pd-catalyzed allylic substitution reaction. We found that trifluoroacetate is a suitable leaving group for the allylic substitution reaction. Various nucleophiles containing carbon, nitrogen, and sulfur can be applied to the method. Both 1,4-syn- and 1,4-anti-adducts were synthesized with high stereoselectivity by using stereodivergent reduction of the propargyl alcohols followed by allylic substitution reaction. 相似文献
15.
Kaoru Sano Yoshihito Kohari Hiroto Nakano Chigusa Seki Mitsuhiro Takeshita Micho Tokiwa 《合成通讯》2016,46(1):46-54
Synthesis of bicyclic compounds was achieved via a lipase-catalyzed, stereoselective, domino Michael–aldol reaction of 2-methyl-1,3-cycloalkanedione and methyl vinyl ketone. Appropriate reaction conditions, including the type of enzyme, solvent, and temperature, were determined. In addition, the effects of solvent polarity and addtives were investigated. The reaction proceeded in the presence of lipase AS in a solution of 20% acetone in dimethylsulfoxide (DMSO) at 10 °C for 8 days, followed by the addition of p-toluenesulfonic acid (TsOH) to afford bicyclic compounds in 51–83% yields with moderate stereoselectivity. Although this domino Michael–aldol reaction showed only moderate stereoselectivity, even with the acid-supported enhancement of the reaction, these results represent potential new applications for lipase. 相似文献
16.
17.
18.
Two novel coordination compounds, namely [Cu2(BDMAEE)(CH3COO)4]n(1) and[Ni(BDMAEE)Cl2](2)[BDMAEE=bis(2-dimethylaminoethyl) ether], have been synthesized and characterized by IR, elemental analysis, PXRD and X-ray single crystal diffraction. In compound 1, the central Cu(Ⅱ) ion is coordinated with four oxygen atoms and one nitrogen atom, forming a distorted square pyramidal geometry. The asymmetric units composed of one Cu(Ⅱ) ion, two acetates and a half of BDMAEE are connected to form an infinite 1D chain structure by the bridging acetate and the BDMAEE. In compound 2, the central Ni(Ⅱ) ion is coordinated with one oxygen atom, two chlorine anions and two nitrogen atoms, forming a distorted square pyramidal geometry. The compounds exhibited excellent catalytic properties in the Henry reaction of nitromethane with some aromatic aldehydes, and the optimized reaction conditions were obtained. 相似文献
19.
An efficient synthetic method for 1′-aryl-2′-(2-oxoindolin-3-yl)spiro[indoline-3,5′-pyrroline]-2,3′-diones was successfully developed via the one-pot domino reaction of arylamines, acetone, and isatins in acetic acid. The reaction mechanism involved the sequential Michael addition and ring closure of the in situ formed 3-N-aryliminoisatin and isatylidene acetone. 相似文献