以“绿色化学”为例浅谈通识教育公共选修课的课程建设与教学改革

详细阐述了综合性大学本科通识教育公共选修课"绿色化学"的课程建设、教学实践与改革探索，通过对教学侧重点的细致化、课程难易程度的普适化、教学手段的多样化和考评机制的合理化改革，大大激发了各专业学生的学习兴趣，显著提高了公选课的教学效果，既明确了"绿色化学"作为各专业通识教育课程的总体建设目标与实施方案，也为其他化学类通识教育课程的建设提供了可借鉴的教学经验和改革思路。     

基于学科交叉融合的通识选修课程建设实践——以“化学与文物考古”课程为例

在“双一流”建设背景下,如何通过课程实施来培养具有跨学科素养的复合型人才已成为一流本科专业人才培养的目标问题。以“化学与文物考古”课程为例,归纳出了基于学科交叉融合的通识选修课程建设的基本做法和实践经验,特别是此课程使不同专业的学生接触到了跨学科素养形成所依赖的跨学科内容,从而为高校培养具备综合创新能力的跨学科人才提供重要抓手。因此,本课程的实践探索可为高校交叉学科融合的通识选修课程的建设提供经验启示。     

化学社会课程资源开发及教学范例——水的净化与水资源保护

课程资源逐步走向开放化、共享化和社会化，社会已成为实施教育教学活动的重要场所。以"水的净化与水资源保护"主题内容为教学范例，提出了化学社会课程资源开发的思路和教学实施流程：在"前置学习"中通过社会课程资源的亲身实践，把化学的课堂延伸到社会领域；在"展示分享"中将获取的有效资源与课堂学习关联，实现知识与生活的有效链接；在"整理评价"中完成知识建构和巩固过程，让学生感受真实、有用的化学。     

化学类通识教育公选课的“三知三性”改革与实践——以“微量元素与人体健康”为例*

以综合性大学开设的化学类通识教育公共选修课“微量元素与人体健康”为例,应用“三知三性”的教学理念对课程进行改革与实践,将化学知识、医药卫生知识、人文历史知识进行有机融合,同时实现课程思政性、科普性、趣味性的协调统一,为大学化学与健康系列通识教育公选课的课程建设提供有效的新方法与新思路。     

综合性大学通识课程“化学与健康”的教学探索

通识课程是高校专业教学内容的重要组成部分,对于提高本科人才培养质量具有深远的作用。通识课“化学与健康”的教学内容涉及化学、生命、药学、医学、环境等学科。该课程可以拓宽学生知识面、促进多学科交叉,达到提高科学素养的目的。以通识课“化学与健康”教学实践为基础,针对综合性大学该课程的建设基础、课程目标及教学内容设计、教学方法与手段、教学效果、思政元素的引入等方面进行了讨论,调研了国外相关课程设置的特点,为加强高校、尤其是综合性大学通识课程的建设提供参考。     

优化全日制化学教育硕士培养模式的探讨

全日制教育硕士（学科教学·化学）研究生培养是一个具有挑战性的、全新的研究课题。从"目标定位""课程优化"和"实践提升"3个方面对化学教育硕士培养进行探讨。在"目标定位"上应培养化学教育硕士具有较强的化学课堂教学能力和教研能力，在"课程优化"上，应优化更具功能化和结构化的课程体系，在"实践提升"上应搭建基于科学态磨课的全类型、全环节的实践平台。     

化学通识课程“人文化学”中的文化自信培养——中国陶瓷的魅力

通识教育是引领广大学子形成完整的知识架构,走向智与美兼具的人生的重要课程。本文以笔者所开设的化学类通识课程“人文化学”中讨论中国陶瓷的部分为例,介绍了中国陶瓷发展的几个重要阶段的艺术特色及其背后的化学基础,探索了如何在通识教育中将科学知识与文化底蕴有机结合,激励学生增强民族文化自信,培养学生提高科学和人文素养。     

以“理-工-医”交叉融合实现源头创新——生物医学工程交叉学科研究生培养实践探索

针对科学技术和国家社会发展对生物医学创新型人才的需求，依托于学校的重大项目培育和新兴交叉学科研究课题，建立了生物医学工程与化学、物理、材料、电子和医学等"理-工-医"多学科交叉科研平台。基于"以人为本""全面发展"等现代教育理念和"以学生发展为中心"的高等教育思想，通过组建跨学科的研究生导师团，多导师联合指导，夯实学生多学科基础知识，加强学生对知识的理解和使用，拓宽研究生知识广度，着力培养研究生源头创新能力，打造研究生解决多学科交叉重要问题的能力。实践表明，多学科交叉科研平台在激发研究生源头创新思维、拓展专业知识、培养工程实践能力等方面起到重要的作用。对继续完善多学科交叉的研究生培养体系建设给出了建议。     

地方高校化学主题通识教育课的实践与反思——以“美好生活与化学”课程为例

基于地方高校开设化学主题通识教育课的实践经历,介绍"美好生活与化学"课程定位、模块设置、主题确定、备课选材,探索课程中融入科学新闻,并从师生互动、课堂拓展、兴趣导向和课件设计4个方面介绍了本课程的教学理念和实施特色,还针对课程团队建设、课程评价、资源建设和对于师范生的教育4个方面进行了反思。     

新文科背景下理论与实践相结合的考古化学教学模式探索

在新文科建设背景下，我们将化学和考古学融合构建了理论实践相结合的通识核心课程考古化学，打破了文、理学科壁垒，对学生进行理论知识和实验技能紧密结合的跨学科培养。同时结合开放创新实验、毕业设计，根据学生兴趣和职业发展规划量身打造个性化研究课题，引导学生在应用化学理论知识和实验技能解决考古实际问题的过程中建立化学、考古学紧密结合的综合创新思维，提升学生的科研创新能力，为新型文理复合型人才的培养提供了思路。     

α-Amino acid derived enaminones and their application in the synthesis of N-protected methyl 5-substituted-4-hydroxypyrrole-3-carboxylates and other heterocycles

A new and simple synthesis of novel N-protected methyl 5-substituted-4-hydroxypyrrole-3-carboxylates, which exist in equilibrium with their 4-oxo tautomers, has been developed in two steps starting from N-protected α-amino acids. The key intermediates are enaminones, which can also be isolated, characterized, and used for the construction of other functionalized heterocycles, before they spontaneously decompose to pyrrole products. 4-Hydroxypyrroles are prone to partial aerial oxidation but can be efficiently alkylated or reduced to stable polysubstituted pyrrolidine derivatives.     

Specific intramolecular aromatic CH insertion of diazosulfonamides

The chemoselectivity in the intramolecular CH insertion of various diazosulfonamides has been experimentally studied. The results reveal that the aliphatic 1,4-, 1,5-, or 1,6-C(sp³)?H insertions of diazosulfonamides are not accessible, while the aromatic 1,5-C(sp²)?H insertion can be realized specifically by adjusting the diazo-adjacent group. In addition, the general chemoselectivities in the intramolecular CH insertions of diazosulfonyl compounds are summarized. Generally, diazosulfones undergo both aromatic 1,5-C(sp²)?H and aliphatic 1,5- and 1,6-C(sp³)?H insertions, while diazosulfonates undergo aliphatic 1,5- and 1,6-C(sp³)?H insertions. However, diazosulfonamides only undergo aromatic 1,5-C(sp²)?H insertion.     

N-Heterocyclic carbene-palladacyclic complexes: synthesis,characterization and their applications in the C-N coupling and α-arylation of ketones using aryl chlorides

N-Heterocyclic carbene-palladacyclic complexes 3 were successfully achieved in a one-pot procedure under mild conditions. The structure of 3a was unambiguously confirmed by X-ray single crystal diffraction and it was an active catalyst in the Buchwald-Hartwig amination and α-arylation of ketones even at very low catalyst loadings (0.01?mol%).     

Iodine-mediated oxidative Pictet-Spengler reaction using terminal alkyne as the 2-oxoaldehyde surrogate for the synthesis of 1-aroyl-β-carbolines and fused-nitrogen heterocycles

An efficient iodine-mediated oxidative Pictet-Spengler reaction in dimethyl sulphoxide (DMSO) using terminal alkynes as the 2-oxoaldehyde surrogate for the synthesis of aryl (9H-pyrido[3,4-b]indol-1-yl)methanones is described. The scope of the protocol includes the total synthesis of Fascaplysin, Eudistomins Y₁ and Y₂. The methodology is extended for preparing pyrrolo[1,2-a]-quinoxaline and indolo[1,5-a]quinoxaline derivatives. The utility of 1-aroyl-β-carbolines was demonstrated by performing palladium-catalyzed β-carboline directed ortho-C(sp2)-H functionalization of the phenyl ring with thiomethyl (SMe) group using DMSO as source and for accessing 4-aryl-canthin-6-ones.     

Facile synthesis of bicyclic 1-arylpyrazol-5-ones

In this Letter, we described a facile method for constructing fused bicyclic 1-arylpyrazol-5-one ring system. We employed various methylene-containing carboxylic acids as the substrates and proved that the pyrazolone ring closure requires activated methylene group in intermediate II. Accordingly, a series of structurally diversified, fused bicyclic 1-arylpyrazol-5-ones was prepared in moderate to high yields using the requisite substrates.     

A carbanion induced synthesis of highly congested pyrazole and imidazole containing heterocycles

An efficient approach to the synthesis of highly congested di, penta and hexacyclic pyrazoles as well as imidazole fragment containing novel heterocyclic molecule has been developed through a carbanion induced transformation of suitably functionalized 2H-pyran-2-ones, benzo[h]chromene and thiochromeno[4,3-b]pyrans. Due to the presence of fluorescence, we report their prime application metal sensor as off/on switching in ferric ions.     

Synthesis of pyrrolo[1,2-a]pyrazines and pyrazino[1,2-a]indoles by Curtius reaction in Morita-Baylis-Hillman derivatives

Synthesis of substituted pyrrolo[1,2-a]pyrazines and pyrazino[1,2-a]indoles from the Morita-Baylis-Hillman derivatives of acrylates via saponification followed by Curtius reaction is described.     

正丁胺对激光染料荧光谱影响的研究

用正丁胺作为碳源,采用射频辉光放电制备碳膜,选用激光染料R6G和聚乙二醇混合液作为蒸气源,采用单源热蒸发,在蒸发室与染料同时沉积得到混合膜,用拉曼光谱和红外光谱分析了碳膜的结构和键合方式,分析表明:碳膜中存在胺基团和氢原子.混合膜的荧光谱测量结果表明,认为正丁胺对染料荧光谱的影响是因为胺基和氢原子的存在.     

Selective synthesis of 4,5-dihydroimidazo- and imidazo[1,5-a]quinoxalines via modified Pictet–Spengler reaction

An efficient tandem approach for the selective synthesis of 4,5-dihydroimidazo[1,5-a]quinoxalines 6a–g and imidazo[1,5-a]quinoxalines 7a–h by the reaction of 2-imidazolyl anilines 4a–c with aryl aldehydes 5a–k under mild reaction conditions is described. Introduction of electron releasing alkyl groups in substrates 4a–b was found to be instrumental for the success of the reaction.     

Understanding the Diels-Alder reactivity of 1,2-azaborine analogues

The Diels-Alder reactivity of 1,2-heteroborines (H₄C₄B(H)X, X?=?NH, PH, AsH; O, S, Se) has been computationally explored by means of Density Functional Theory (DFT) calculations. The influence of the HB?=?X fragment on the reactivity of the system has been quantitatively analyzed in detail by means of the so-called Activation Strain Model (ASM) of reactivity. It is found that the interaction between these species and the dienophile is significantly stronger than that computed for their all-carbon isoelectronic counterpart, benzene. In addition, the strain energy plays a key role in the observed reactivity trends. The role of the aromaticity strength of these heteroarenes on the reactivity is also assessed.