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1.
Sh. A. Kadirova M. M. Ishankhodzhaeva N. A. Parpiev A. Tozhiboev B. Tashkhodzhaev Z. Karimov 《Russian Journal of General Chemistry》2008,78(12):2398-2402
A complex compound of Cu(II) nitrate with 2-amino-5-ethyl-1,3,4-thiadiazole was synthesized and its structure was studied by the methods of IR spectroscopy and X-ray crystal analysis. The complex has the composition Cu(NO3)2(2-amino-5-ethyl-1,3,4-thiadiazole)4 with four molecules of the heterocyclic ligand (coordination through nitrogen atoms of thiadiazole rings) and one of nitrate ions (the other is replaced in the second sphere) entering into the coordination sphere of the complex polyhedron. The internal coordination sphere of the complex has the form of a tetragonal pyramid with 2-amino-5-ethyl-1,3,4-thiadiazole ligands in the sites of its base and the oxygen atom of the nitrate ion in a slightly distorted vertex of the pyramid. 相似文献
2.
N. N. Tonkikh M. V. Petrova A. F. Mishnev K. V. Ryzhanova F. M. Avotin'sh A. Ya. Strakov 《Chemistry of Heterocyclic Compounds》2000,36(7):822-829
The corresponding 2,3-substituted 4(3H)-quinazolinones were obtained in the reactions of 2-methyl- and 2-phenyl-4-oxo-3,1-benzoxazines with 1-amino-1,2,4-triazole, 4-amino-2,3-dimethyl-1-phenyl-5-pyrazolone, 2-amino-5-ethyl-1,3,4-thiadiazole, 3-amino-6,6-dimethyl-4-oxo-4,5,6,7-tetrahydroindazole, 1-amino-3-cyano-4,6-dimethyl-2-pyridone, and 1-amino-3-cyano-6-phenyl-4-trifluoromethyl-2-pyridone. The formation of N-benzolyanthranilamides in the reactions of 2-phenyl-4-oxo-3,1-benzoxazine with 2-amino-5-ethyl-1,3,4-thiadiazole and 1-amino-3-cyano-6-phenyl-4-trifluoromethyl-2-pyridones was exceptional. The structures of two of the products have been confirmed by X-ray crystallography.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 7, pp. 936–943, July, 2000. 相似文献
3.
Sh. A. Kadirova M. M. Ishankhodzhaeva N. A. Parpiev Z. Karimov A. Tozhiboev B. Tashkhodzhaev 《Russian Journal of General Chemistry》2007,77(10):1799-1801
A complex of Cu(II) chloride with 2-amino-5-ethyl-1,3,4-thiadiazole (AET) was prepared, and its structure was studied by IR spectroscopy and single crystal X-ray diffraction. The complex has the composition CuCl2(AET)4. The coordination sphere of the copper atom includes four molecules of the heterocyclic ligand coordinated via N atoms of thiadiazole rings and one of Cl? anions; the second Cl? anion is in the outer sphere. 相似文献
4.
William A. Remers Gabriel J. Gibs Martin J. Weiss 《Journal of heterocyclic chemistry》1969,6(6):835-840
A new route for the synthesis of 2-amino-5-(l-methyl-5-nitro-2-imidazolyl)-1,3,4-thiadiazole ( 1 ) is described. This route was based upon the preparation of 2-amino-5-halomethyl-1,3,4-thiadiazoles by condensation of haloacetic acids with thiosemicarbazide. One of these intermediates, 2-acetamido-5-dichloromethyl-1,3,4-thiadiazole ( 4 ), was hydrolyzed to the corresponding 5-amino-2-carboxaldehyde 6 , which was trapped as its oxime 5 . 5-Acetamido-1,3,4-thiadiazole-2-carbonitrile ( 7 ), formed upon dehydration of 5 , was then converted into 2-amino-5-(2-imidazolyl)-1,3,4-thiadiazole ( 11 ) by a route based on the Pinner amidine synthesis. Methylation and nitration of the imidazole moiety then completed the preparation of 1. 相似文献
5.
Reaction of sodium arylsulfinate with 2-aryl-5-chloro-1,3,4-thiadiazole gave 2-aryl-5-arylsulfonyl-1,3,4-thiadiazole (3) in good yield. Starting from readily available 2-amino-5-benzylmercapto-1,3,4-thiadiazole compound 7 was obtained in three steps in moderate yield. Reaction of compound 7 with sodium arylsulfinate afforded 2,5-diarylsulfonyl-1,3,4-thiadiazole ( 11 ). Oxidation of compound 10 with hydrogen peroxide in acetic acid gave 2-arylsulfonyl-5-benzylsulfonyI-1,3,4-thiadiazole ( 12 ), in high yield. 相似文献
6.
Billy Kar-On Leung Michael J. Hudson Michael G. B. Drew 《Transition Metal Chemistry》1992,17(4):352-355
The crystal structure of 2-amino-5-benzylmercapto-1,3,4-thiadiazole (Ben-SNTD) has been determined. The thiadiazole ring is
planar and aromatic, and the 1,3,4-thiadiazole-2-amino-5-thiol moiety is covalently bound to the benzyl group through the
sulphur atom. Spectroscopic evaluation and thermal analysis of the complex formed between Ben-SNTD and CuCl2 indicate a compound with a CuL2 type structure. 相似文献
7.
The reactions of 2-amino-1,3,4-thiadiazole with 1,3-dicarbonyl compounds are described. 2,4-Pentanedione gave 2-thiocyanato-4,6-dimethylpyrimidine while diethylmalonate and ethyl acetoacetate yielded 5-hydroxy-7H-1,3,4-thiadiazolo[3,2-a]pyrimidin-7-one and 7-methyl-5H-1,3,4-thiadiazolo[3,2-a]pyrimidin-5-one, respectively. The structure of the latter compound was confirmed by a synthesis of the alternative isomeric structure (5-methyl-7H-1,3,4-thiadiazolo[3,2-a]pyrirnidin-7-one) from 2-amino-1,3,4-thiadiazole and α-bromocrotonic acid. 相似文献
8.
E.E Lawson H.G.M Edwards A.F Johnson 《Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy》1997,53(14):2571-2577
Mercapto-thiadiazoles having potential anti-wear behaviour are reacted with polymers with existing viscosity index-improving properties in order to produce materials which may find a use as multifunctional lubricant additives. 2,5-Dimercapto-1,3,4-thiadiazole, 2-amino-5-mercapto-1,3,4-thiadiazole and 2-methyl-5-mercapto-1,3,4-thiadiadiazole were reacted with low MW polybutadiene containing vinyl-1,2, cis-1,4 and trans-1,4 (C=C) groups. The reactions were monitored using FT-Raman spectroscopy in order to determine quantitatively the consumption of the individual structural units when reacted with thiadiazoles. 2,5-Dimercapto-1,3,4-thiadiazole reacted readily with the polybutadiene, achieving 80% reaction within a few hours. The thiadiazole reacted selectively with the order of addition being cis>vinyl>trans. 2-Amino-5-mercapto-1,3,4-thiadiazole and 2-methyl-5-mercapto-1,3,4-thiadiazole were found to react more slowly and hence to a lesser extent (40 and 25%, respectively) over a similar time scale. 相似文献
9.
Domenico Spinelli Renato Noto Giovanni Consiglio Francesco Buccheri 《Journal of heterocyclic chemistry》1977,14(2):309-311
The rate constants of the deearboxylation reaction in water of 5-amino-1,3,4-lhiadiazole-2-carboxylic acid (I) to 2-amino-1,3,4-thiadiazole (III) over the pH range O.25-3.91 have been measured and the activation parameters determined. The results obtained have been compared with previous results on the deearboxylalion of 5-amino-1,3,4-oxadiazole-2-earboxylic acid (II) to gain information on the mechanism of the reaction studied. 相似文献
10.
11.
T. V. Shokol V. V. Semenyuchenko V. P. Khilya 《Chemistry of Heterocyclic Compounds》2004,40(12):1588-1594
-(5-Phenyl-1,3,4-thiadiazolyl-2)-6-ethyl-2,4-dihydroxyacetophenone was synthesized by the condensation of 4-ethylresorcinol with 2-cyanomethyl-5-phenyl-1,3,4-thiadiazole. Interaction of the former with carboxylic acid anhydrides and halides and subsequent hydrolysis gave 2-R-6-ethyl-7-hydroxy-3-(5-phenyl-1,3,4-thiadiazoyl)chromones.Translated from Khimiya Geterotsiklicheskikh Soedinenii, 1840–1847, December, 2004. 相似文献
12.
E. S. Krylova V. E. Semenov I. V. Galyametdinova V. D. Akamsin D. R. Sharafutdinova V. S. Reznik 《Russian Journal of Organic Chemistry》2011,47(5):746-752
Reactions of 1,3-bis(bromopentyl)-5(6)-substituted uracyls with a series of five-membered heterocycles containing in the ring
N, S, or O atoms and a mercapto group as a substituent at the carbon atom of the ring afforded uracyl derivatives of acyclic
and macrocyclic structure with 2-thiobenzoxazole, 2-thio-5-methyl-1,3,4-thiadiazole, 2-thiobenzimidazole, and 2,5-dithio-1,3,4-thiadiazole
fragments. N atoms of benzoxazole and imidazole fragments of compounds obtained undergo alkylation and quaternization with
alkyl iodides and alkyl tosylates. 相似文献
13.
By interaction of AgClO4 with 2-amino-5-allylthio-1,3,4-thiadiazole (Aаtd) in the ethanol solution, a new [Ag(Aаtd)(ClO4)] π complex is obtained. It is studied by single crystal X-ray diffraction. 相似文献
14.
15.
N-[5-(Е)-1,3,4-噻二唑-2-基]-N'-芳基脲的合成、晶体结构及生物活性 总被引:2,自引:0,他引:2
为了寻找高活性的脲类细胞分裂素,通过2-氨基-5-(Е)-苯乙烯基-1,3,4-噻二唑与芳酰基叠氮化物反应,合成了11种新的含1,3,4-噻二唑环芳基脲类衍生物,其中芳酰基叠氮化物直接由芳酸、三氯氧磷与叠氮钠采用"一锅法"制得,再经加热发生Curtius重排转化为异氰酸酯.目标化合物的结构用红外光谱、核磁共振氢谱、质谱和元素分析进行了表征,并用X射线单晶衍射实验测定了化合物3g的结构.初步的生物活性测试表明,部分目标化合物在10 mg/L浓度下表现出良好的细胞分裂素活性,其中3c的活性超过50%. 相似文献
16.
Mohamed Al-Omar Omar A. Al-Deeb Hamad A. Al-Khamees Ali A. El-Emam 《Phosphorus, sulfur, and silicon and the related elements》2013,188(12):2509-2517
Cyclization of 1-(3,4,5-trimethoxybenzoyl)-4-substituted thiosemicarbazides 2a–g with sulphuric acid at ambient temperature afforded the selectively demethylated products 2-(4-hydroxy-3,5-dimethoxyphenyl)-5-substituted amino-1,3,4-thiadiazoles 4a–g. Meanwhile, dehydrative cyclization of 1-(3,4,5-trimethoxybenzoyl)-4-(benzyl or t-butyl)thiosemi- carbazides 2h, i with sulphuric acid yielded 2-(4-hydroxy-3,5-dimetho xyphenyl)-5-amino-1,3,4-thiadiazole 5. On the other hand, dehydration of 2h, i by heating with phosphorus oxychloride yielded 2-(3,4,5-trimethoxyphenyl)-5-amino-1,3,4-thiadiazole 6. 相似文献
17.
2-Phenyltetrazolo[4,5-a]-1,3,4-thiadiazole ( 4 ), in its azido form, reacted with diethyl fumarate and diethyl maleate to give 2-phenyl-7-carbethoxy-5H-1,3,4-thiadiazolo[2,3-a]pyrimidin-5-one ( 5 ). To assign the structure of compound 5 , 2-phenyl-5-carbethoxy-7H-1,3,4-thiadiazolo[2,3-a]pyrimidin-7-one ( 6 ) was prepared from the reaction of 2-amino-5-phenyl-1,3,4-thiadiazole ( 7 ) with diethylacetylene dicarboxylate. Physical properties and spectral data of compound 6 were different from compound 5 . Theoretical and experimental aspects are discussed. 相似文献
18.
Theoretical studies of molecular structure and vibrational spectra of 2-amino-5-phenyl-1,3,4-thiadiazole 总被引:2,自引:0,他引:2
Atalay Y Yakuphanoglu F Sekerci M Avci D Başoğlu A 《Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy》2006,64(1):68-72
The molecular geometry and vibrational frequencies of 2-amino-5-phenyl-1,3,4-thiadiazole (C8H7N3S) in the ground state has been calculated using the Hartree-Fock and density functional method (B3LYP) with 6-31G(d) basis set. The optimized geometric bond lengths and bond angles obtained by using HF and DFT (B3LYP) show the best agreement with the experimental data. Comparison of the observed fundamental vibrational frequencies of 2-amino-5-phenyl-1,3,4-thiadiazole (C8H7N3S) and calculated results by density functional B3LYP and Hartree-Fock methods indicate that B3LYP is superior to the scaled Hartree-Fock approach for molecular vibrational problems. 相似文献
19.
Synthesis and Structure of 2-Isobutyl-6-(2'''',4''''-dichlorophenyl)imidazo[2,1-b]-1,3,4-thiadiazole 总被引:1,自引:0,他引:1
1INTRODUCTIONThethiadiazoleandimidazolecompoundsareextensivelystudiedduetotheirspectrumbioacti-vities[1~4].Amongthem,theimidazo[2,1-b]-1,3,4-thiadiazolederivativesarepharmaceuticallyimpor-tantbecauseoftheirimmunostimulant[5],antifugal[6],antimicrobial[7]… 相似文献
20.
Lan-Qin Chai Hong-Song Zhang Wen-Kui Dong Yan-Ling Zhao 《Phosphorus, sulfur, and silicon and the related elements》2013,188(7):1332-1337
A series of coumarin-3-yl substituted unsymmetrical ureas were synthesized by the reaction of 3-coumarin isocyanate, which was prepared from 3-coumarinyl azide by Curtius rearrangement, with various aromatic amines, 2-amino-5-phenyl-1,3,4-thiadiazole, and 2-amino-5-aryloxymethylene-1,3,4-thiadiazoles under microwave irradiation. Compared to conventional methods, this synthesis has the advantages of mild reaction conditions, easy handling, and high yields. The products have been characterized by analytical and spectral (IR and 1H NMR) data. 相似文献