共查询到18条相似文献,搜索用时 250 毫秒
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以1,4-二乙基-7-羟基四氢喹喔啉-6-甲醛为基础,设计合成了一种具有长波长发射、较大斯托克斯位移的新型肼二腙类荧光探针L.在探针L的二甲基亚砜(DMSO)溶液中加入Cu~(2+)和CO~(2+)后,溶液颜色由黄色分别变为粉色和无色,可裸眼识别Cu~(2+)和Co~(2+).利用L与Cu~(2+)形成的配合物,在DMSO/H_2O(V:V=7:3,HEPES,1×10~(-2)mol/L,pH=7.4)缓冲溶液中可荧光"OFF-ON"识别H_2S.试纸条实验表明,L-Cu~(2+)对不同浓度H_2S显色明显,可以通过裸眼和荧光双通道快速检测H_2S.此外,利用Discovery Studio分子模拟软件,通过分子L结构反向找靶,并用CDOCKER程序进行分子对接,发现分子L对2x0v蛋白(来自人类的P53蛋白)有很好的结合作用,有望在医药领域得到应用. 相似文献
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《有机化学》2020,(4)
硫化氢(H_2S)和pH在环境和细胞内的许多过程中起着至关重要的作用.为了更好地研究其功能,需要一种快速、灵敏地检测H_2S和pH的荧光探针.设计合成了以萘二酰亚胺为荧光基团,叠氮为识别位点,基于分子内电荷转移(ICT)机制的反应型荧光探针L.该探针L在较宽的pH范围(4~11)内稳定性好,对H_2S的选择性高,响应速度快(3 min),检测限(1.18μmol·L~(-1))较低,在0~20μmol·L~(-1)的范围内,荧光强度与H2S浓度呈良好的线性关系(R~2=0.99823).此外,当体系中存在30倍的H_2S时,在2≤pH≤6.5的范围内, L对pH变化显示线性关系(R~2=0.98764),可用作pH探针.该探针在检测H_2S和30倍H_2S存在条件下研究细胞微环境pH变化的方法,在分析检测和病理分析等方面具有潜在的应用前景. 相似文献
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本文利用2-氨基吡啶与4-二乙胺基水杨醛反应合成了5-二乙胺基-2-(吡啶-2’-亚氨甲基)苯酚(探针L),对其结构进行了表征。在DMSO/Tris(6:4, v/v, pH =7.4)溶液中,探针L高选择性荧光“关-开”识别Zn2+,在365 nm紫外灯照射下,由无荧光变成蓝色荧光。实验表明,探针L与Zn2+的结合比为1:1,结合常数为2.6×103 L. mol-1,检测限为 9.39×10-7mol/L,pH适用范围为7-11,并可检测水样中的Zn2+。 相似文献
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以4-硝基-1,8-萘酐、N,N-二甲基乙二胺为主要原料合成了一种荧光探针:4-(2′-N,N-二甲基氨基乙基)氨基-N-(2-N,N-二甲基氨基)乙基-1,8-萘酰亚胺(DDN)。研究了其紫外可见吸收和荧光发射光谱。考察了Fe3+,Cr3+,Mn2+,Ni2+,Zn2+,Cu2+和Co2+离子对该化合物荧光发射光谱的影响,结果表明Cr3+离子能使DDN荧光显著增强。滴定实验结果推测DDN与Cr3+的结合比为1∶2。在DDN浓度为1.0×10-5mol/L时,Cr3+浓度在5.0×10-7~2.0×10-5mol/L范围内,DDN荧光强度(F)与Cr3+离子浓度[Cr3+]呈良好的线性关系,线性方程为F=9430.3527+14600.2973[Cr3+],相关系数r=0.9976。检测限为4.3×10-7mol/L。 相似文献
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通过席夫碱反应将2-氨基4-甲基吡啶与4-(二乙氨基)水杨醛结合,设计并合成出一种新型的荧光探针L,该探针能特异性识别Zn2+。通过质谱、1H NMR以及13C NMR表征其结构,并利用荧光光谱、紫外-可见吸收光谱研究了探针L在CH3OH-H2O(V:V=8:2,Tris-HCl缓冲液,pH=7.4)中对各种离子的选择识别能力。实验结果显示,向探针L中加入Zn2+之后,溶液从无荧光变成蓝色荧光,且457 nm处出现一发射峰。Job’s plot工作曲线结果和密度泛函理论(DFT)计算表明探针L与Zn2+结合计量比为1:1。荧光滴定结果表明探针L对Zn2+的检测极限可低至2.7×10-8 mol·L-1,结合常数为1.32×104 L·mol-1,pH应用范围4.0~10.0。对真实水样中的Zn2+进行检测,平均回收率大于98%,RSD小于1.61%,表明探针L能够检测真实水样中的Zn2+。 相似文献
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Muhammad Saleem Nam Gyu Choi 《International journal of environmental analytical chemistry》2015,95(7):592-608
A novel fluorogenic signalling probe (E)-3-(4-methoxyphenyl)-4-[(4-nitrobenzylidene)amino]-1H-1,2,4-triazole-5(4H)-thione (6) for the carbonate and bicarbonate ions has been developed through microwave assisted Schiff base formation reaction. The anion recognition occurs through hydrogen bonding assessed by 1H NMR titration experiments. The photophysical results of probe 6 corroborates its applicability as an optical sensing platform for carbonate as well as bicarbonate ions in mixed aqueous organic media depending on pH of reaction solution. The fluorescence emission signal enhancement at 424 nm and considerable shift in the signal position as well as molar absorptivity to the probe absorption bands upon CO32? and HCO3? addition suggest the affinity of probe 6 towards these ions in comparison to a variety of competitive ions in aqueous/ethanol (7:3, v/v) at neutral pH and ambient temperature. From the fluorescence titration experiment, the limit of detection was calculated to be 1.91 μM. 相似文献
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A Highly Selective Two‐Photon Fluorescent Probe for Detection of Cadmium(II) Based on Intramolecular Electron Transfer and its Imaging in Living Cells 下载免费PDF全文
Dr. Zhaohua Shi Qingxin Han Dr. Lizi Yang Huan Yang Dr. Xiaoliang Tang Dr. Wei Dou Zhiqi Li Yange Zhang Yongliang Shao Liping Guan Prof. Dr. Weisheng Liu 《Chemistry (Weinheim an der Bergstrasse, Germany)》2015,21(1):290-297
A new quinoline‐based probe was designed that shows one‐photon ratiometric and two‐photon off–on changes upon detecting Cd2+. It exhibits fluorescence emission at 407 nm originating from quinoline groups in Tris‐HCl (25 mM , pH 7.40), H2O/EtOH (8:2, v/v). Coordination with Cd2+ causes quenching of the emission at 407 nm and simultaneously yields a remarkable redshift of the emission maximum to 500 nm with an isoemissive point at 439 nm owing to an intramolecular charge‐transfer mechanism. Thus, dual‐emission ratiometric measurement with a large redshift (Δλ=93 nm) and significant changes in the ratio (F500/F439) of the emission intensity (R/R0 up to 27) is established. Moreover, the sensor H2L displays excellent selectivity response, high sensitive fluorescence enhancement, and strong binding ability to Cd2+. Coordination properties of H2L towards Cd2+ were fully investigated by absorption/fluorescence spectroscopy, which indicated the formation of a 2:1 H2L/Cd2+ complex. All complexes were characterized by X‐ray crystallography, and TD‐DFT calculations were performed to understand the origin of optical selectivity shown by H2L. Two‐photon fluorescence microscopy experiments have demonstrated that H2L could be used in live cells for the detection of Cd2+. 相似文献
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Sergio Stoccoro Barbara Soro Giovanni Minghetti Antonio Zucca Maria A. Cinellu 《Journal of organometallic chemistry》2003,679(1):1-9
Two new 6-substituted 2,2′-bipyridines, L, 6-(2-tolyl)bipy, L1, and 6-(2,6-xylyl)bipy, L2, have been synthesized. Their reactions with Na2[PdCl4] or {Pd(OAc)2} afford either 1:1 adducts [Pd(L)X2] (X=Cl, OAc) or five-membered cyclometallated derivatives [Pd(L1-H)X] arising from C(sp2)H activation. From the chloro-alkyl intermediates [Pd(L)(Me)Cl], in the presence of Na[BAr′4] (Ar′=3,5-(CF3)2C6H3), cationic species [Pd(L)(Me)(S)]+ (L=L1, L2; S=CH3CN) can be obtained. At variance, in less coordinating solvents, e.g. dichloromethane, unexpected activation of a C(sp3)H bond occurs with loss of methane, to afford 6-membered cyclometallated derivatives. The latter species were isolated as [Pd(L-H)(PPh3)][BAr′4]. 相似文献
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Yanan Meng Xinya Yao Dr. Keli Zhong Dr. Yang Li Dr. Lijun Tang 《European journal of organic chemistry》2023,26(18):e202300022
Hydrogen sulfide (H2S), as one of the important endogenous biological regulators, plays a critical role in mediating a wide range of physiological processes. The development of rapid, sensitive, and reliable detection techniques for H2S would be highly appealing. In this paper, a new type of AIE-based fluorescence turn-on probe TPA-M for the detection of H2S has been constructed, involved the rapid release of AIE-based fluorophore TPA-CHO with a remarkable fluorescence turn-on phenomenon in THF/H2O (2/8, v/v, HEPES=20 μM, pH=7.3) medium, exhibiting the attractive advantages such as high sensitivity with the detection limit as low as 1.92×10−3 ppm, excellent selectivity over other anion analytes and biothiols, significant anti-interference ability and fast response time (within 10 min). What's more, the practical application evaluation indicated that the probe TPA-M could be efficiently employed in imaging exogenously added H2S in living MCF-7 cells and detecting H2S in actual water and wine samples. 相似文献
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Han L Zhang Y Kang J Tang J Zhang Y 《Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy》2011,82(1):146-152
In this paper, three kinds of imidazole derivatives, 2-(4-methylphenyl)-4,5-di(2-furyl) imidazole (MDFI), 2-(4-nitrophenyl)-4,5-di(2-furyl) imidazole (NDFI), and 2-(4-tert-butylphenyl)-4,5-di(2-furyl) imidazole (t-BDFI) were synthesized. In an alkaline medium, the chemiluminescence (CL) reaction of imidazole derivatives with H2O2 has been investigated. It was also found that MDFI/H2O2 and t-BDFI/H2O2 systems gave strong CL. When Co2+ was added into the two CL systems, the CL intensity was remarkably enhanced. In the optimum conditions, the CL intensity is linearly related to the logarithm of concentration of Co2+. The linear ranges are 5 × 10−9–2.5 × 10−7 mol/L for MDFI/H2O2 system and 5 × 10−9–2.5 × 10−7 mol/L for t-BDFI/H2O2 system, and the corresponding detection limits are 1.2 × 10−9 mol/L and 1.1 × 10−9 mol/L, respectively. The method was applied to the determination of Co2+ in vitamin B12 injection. Furthermore, the CL mechanism was also discussed. 相似文献
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The stability constants of the complexes of 1-(2-pyridylazo)-2-naphthol with several organotin and lead ions were determined spectrophotometrically in aqueous 20% (v/v) dioxane and were shown to have very high values. The extraction of the complex of (C2H5)2Pb2+ from water into chloroform was studied, and the formation of an extractable (C2H5)2Pb(PAN)(OH) complex is postulated. 相似文献
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《Arabian Journal of Chemistry》2022,15(4):103710
Selective metal ion detection is highly desired in fluorometric analysis. In the current study a curcumin-based fluorescence-on probe/[(2E,6E)-2,6-bis(4-(dimethylamino) benzylidene) cyclohexanone]/probe was designed for the removal of one of the most toxic heavy metal ion i.e. Hg2+. The structure of the probe was confirmed by FTIR and 1H NMR spectroscopic analysis displaying distinctive peaks. The complex formation between probe and Hg2+ ion was also studied by density functional theory to support the experimental results. Chelation enhanced fluorescence was observed upon interaction with Hg2+ ion. Different parameters like pH, effect of mercury ion concentration, contact time, interference study and effect of probe concentration on the fluorescence enhancement were also investigated. A rapid response was detected for Hg2+ ion with limit of detection and quantification as 2.7 nM and 3 nM respectively with association constant of 1 × 1011 M?2. The probe displayed maximum fluorescence intensity at physiological pH. The results showed that the synthesized probe can be employed as an excellent probe for the detection and quantification of Hg2+ ions in aqueous samples with high selectivity and sensitivity due to its higher binding energy and larger charge transferring ability. 相似文献
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R. Battistuzzi 《无机化学与普通化学杂志》1979,448(1):173-180
Complexes of the type Cu(L? S? S? L)X2 (X = Cl, Br) and Cu(L? S? S? L)2X (X = ClO4, BF4) were prepared in CHCl3? MeOH solution from CuX2 · 6 H2O (X = Cl, Br, ClO4, BF4) and bis-[2-(4, 6-dimethylpyrimidyl)]disulphide (L? S? S? L), and examined in the mid-(4000–250 cm?1) and far-i.r. (5000–60 cm?1) regions. Assignments for metal-ligand and metalhalogen vibrations were made. On the basis of these assignments, conductivity measurements and from magnetic moments and visible absorption data, the stereochemistry of the compounds was tentatively inferred. For Cu(L? S? S? L)X2 (X = Cl, Br) species may be proposed an essentially [CuN2X2] in-plane microsymmetry achieved through two pyrimidyl nitrogen atoms of a ligand molecule, to form a seven-membered chelate ring and two halide ions, with probable interaction along the z axis with adjacent molecules. The Cu(L? S? S? L)2X (X = ClO4, BF4) species, may be considered to contain isolated complexes cations, Cu(L? S? S? L) , or polynuclear cationic polymers, Cun(L? S? S? L), in which Cu(I) is, probably via N3S, tetrahedraly coordinated. 相似文献