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2,4—二羟基—3—芳氨基甲基苯乙酮和8—乙酰基—3—芳基—3,4—二… 总被引:1,自引:0,他引:1
研究了在氯化氢-乙醇溶液或乙醇溶液中,2,4-二羟基苯乙酮与甲醛和芳胺的Mannich反应,分别得到了5个2,4-二羟基-3-芳氨基甲基苯乙酮和5个8-乙酰基-3-芳基-3,4-二氧-5-羟基-2H-1,3-苯并恶嗪新化合物,用元素分析,IR,HNMR,MS,UV确定了它们的结构,并成功地实现了2,4-二羟基-3-芳氨基甲基苯乙酮和8-乙酰基-3-芳基-3,4-二氢-5羟基-2H,1,3-苯并恶嗪 相似文献
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研究了3-(1H-苯并三唑-1-亚甲基)-4-氨基-5-巯基-1,2,4-三唑与取代苯甲酸在三氯氧磷催化下的反应,制得10种新的3-(1H-苯并三唑-1-亚甲基)-1,2,4.三唑并[3,4-b]-1,3,4-噻二唑,通过元素分析、IR、 ̄1NMR和MS确证了它们的结构并讨论了其波谱性质。 相似文献
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3-苯基-5-取代苯氨基-6-甲基-1,2,4-三嗪的合成陆忠娥,曾润生,席海涛(苏州大学化学系,苏州,215006)关键词硫代苯甲酰胺,α-乙酰基硫代甲酰苯胺,N'-氨基苯甲脒,3-苯基-5-取代苯氨基-6-甲基-1,2,4-三嗪1,2,4-三嗪类... 相似文献
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3-芳基-4-氨基-1,2,4-均三唑-5-硫酮和2.4-二氯苯氧乙酰异硫氰酸酯在丙酮中于60℃回流,制得10个新的均三唑并[3,4-b]-1,3,4-噻二唑(3a-j)化合物,用元素分析、IR、1HNMR和MS确证了结构,并讨论了反应机制。 相似文献
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3—芳基—5—巯基—1,2,4—均三唑的双—Mannich反应研究 总被引:2,自引:1,他引:2
研究了在氯化氢-乙醇溶液中,3-芳基-5-巯基-1,2,4-均三唑与甲醛和伯胺(芳胺或脂肪胺)的双Mannich反应,合成了13的的稠杂环化合物3,5-二取代0四氢均三唑并「3,4-b」「1,3,5」噻二嗪,经元素分析、I手MS确定了结构,初步测定了该类化合物的生物活性。 相似文献
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3-嘧啶胺基或三嗪胺基甲酰基-4-羟基-2H-1,2-苯并噻嗪-1,1-二氧化物的合成及活性 总被引:1,自引:0,他引:1
通过3-乙氧甲酰基-4-羟基-2-氢(甲基)-2H-1,2-苯并噻嗪-1,1-二氧化物与取代嘧啶胺或均三嗪胺的胺解反应,合成了标题化合物。生物活性测定结果表明多数化合物具有较好的除草活性,部分化合物显示好的植物生长调节活性和抗炎免疫活性。 相似文献
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A novel compound 5-(p-tolyl)-4-[2-(2,4-dichlorophenoxy)acetamido]-1,2,4-tria zole- 3-thione 2a has been synthesized by the reaction of 5-(p-tolyl)-4-amino-1,2,4-triazole-3-thione 1 with 2-(2,4-dich/orophenoxy)acetyl ch/oride. Interestingly, the title compound 2 was obtained when 2a crystallizes from a mixed solution of petroleum ether and ethyl acetate, and it has been characterized by elemental analysis, IR, ^1H NMR spectra and single-crystal X-ray diffraction. The crystal belongs to the triclinic system, space group P1 with a = 9.780(5), b = 10.876(6), c = 11.615(6) /A, a = 104.822(7), β= 94.105(6), ), = 94.305(6)°, V= 1185.7(11)/A3, Z = 2,μ = 0.397 mm^-1, Mr= 497.39, Dx= 1.393 g/cm^3, F(000) = 516, S = 1.097, the final R = 0.0730 and wR = 0.2133 for 4111 unique reflections (Rint = 0.0525) with 3212 observed ones. The dihedral angles made by the triazole ring with the methyl- and chloro-substituted benzene rings are 43.5(7) and 50.2(9)°, respectively. Some intra- and intermolecular hydrogen bonds together with C-H…π interactions existing in the lattice stabilize the crystal structure. 相似文献
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The title compound trans-4-[(5-(2,4-dichlorophenoxy)-3-methyl-1-phenyl-1H-pyra-zol-4-yl)methyleneamino]-1,5-dimethyl-2-phenyl-1,2-dihydropyrazol-3-one 3 (C28H23Cl2N5O2, Mr = 532.41) has been synthesized and its crystal structure was determined by single-crystal X-ray diffraction analysis. It crystallizes in triclinic, space group P1 with a = 8.9438(4), b = 11.6065(5), c = 14.2215(6) , α = 112.566(1), β = 92.324(2), γ = 102.91(1)o, V = 1315.65(10) 3, Z = 2, Dc = 1.344 g/cm3, μ(MoKα) = 0.282 mm-1, λ = 0.71073 , F(000) = 552, the final R = 0.0587 and wR = 0.1578 for 5071 observed reflections (I > 2σ(I)). X-ray analysis reveals that the product is a thermodynamically stable trans isomer. Intra-and intermolecular C(12)-H(12)···O(1) and C(28)-H(28)···O(1)#1 hydrogen bonds were observed in the title compound. 相似文献
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Romualdas Smicius Virginija Jakubkiene Milda M. Burbuliene Povilas Vainilavicius 《Monatshefte für Chemie / Chemical Monthly》2002,133(2):173-181
Summary. Treatment of 5-(6-methyl-2,4-dioxo-1,2,3,4-tetrahydro-3-pyrimidinyl)-methyl-1,3,4-oxadiazole-2-thione with haloalkanes yielded
oxadiazole S-alkyl derivatives, whereas its reaction with formaldehyde and amines resulted in formation of oxadiazole N(3)-aminomethyl
derivatives. The alkylation of 2-alkylsulfanyl-5-(6-methyl-2,4-dioxo-1,2,3,4-tetrahydro-3-pyrimidinyl)-methyl-1,3,4-oxadiazoles
with methyl bromoacetate proceeded at the N(1)-position of pyrimidine to give 2-alkylsulfanyl-5-(1-methoxycarbonylmethyl-6-methyl-2,4-dioxo-1,2,3,4-tetrahydro-3-pyrimidinyl)-methyl-1,3,4-oxadiazoles,
whereas aminomethylation, bromination, or nitration took place at position 5 of pyrimidine ring and afforded the corresponding
5-pyrimidine substituted derivatives.
Received May 9, 2001. Accepted (revised) August 17, 2001 相似文献
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Povilas Vainilavicius Romualdas Smicius Virginija Jakubkiene Sigitas Tumkevicius 《Monatshefte für Chemie / Chemical Monthly》2001,132(7):825-831
Summary. In the reaction of 5-(6-methyl-2,4-dioxo-1,2,3,4-tetrahydro-3-pyrimidinyl)-methyl-1,3,4-oxadiazole-2-thione with hydrazine
hydrate, 5-(6-methyl-2,4-dioxo-1,2,3,4-tetrahydro-3-pyrimidinyl)-methyl-4-amino-1,2,4-triazole-3-thione was formed. The reactions
of the latter with ethyl bromoacetate and chloroacetonitrile in the presence of triethylamine proceeded under formation of
the corresponding S-alkylated derivatives, whereas from its reaction with ω-bromoacetophenone and ethyl 4-chloroacetoacetate
triazolothiadiazines were obtained. Treatment of the title compound with ethyl 2-chloroacetoacetate led to the formation of
5-(6-methyl-2,4-dioxo-1,2,3,4-tetrahydro-3-pyrimidinyl)-methyl-4-N-acetylamino-(3-ethoxy-carbonylmethylthio)-1,2,4-triazole.
Performing of the latter reaction without basic catalyst gave a triazolothiadiazine. Treatment of the S-alkylated derivatives
with sodium methoxide resulted in triazolothiadiazines via a cyclocondensation reaction.
Received November 20, 2000. Accepted January 15, 2001 相似文献
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The 13C NMR spectra of twelve 3-aryl-4-(5-aryl-Δ2-l,2,4-oxadiazolin-3-yl)sydnones and twelve 3-aryl-4-(5-aryl-l,2,4-oxadiazol-3-yl)sydnones have been measured and assigned by means of proton-noise decoupling and DEPT-experiments. The coupling constants were determined by means of gated decoupling, and NOE effects were observed by comparison of proton-decoupled and inverse-gated decoupled spectra. Differences shown by the oxadiazoline and the oxadiazole rings and the substitution effects are discussed. 相似文献
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Rodinovskaya L. A. Gromova A. V. Shestopalov A. M. Nesterov V. N. 《Russian Chemical Bulletin》2003,52(10):2207-2213
Substituted 3-hydroxypyrazoles, which were prepared based on ethyl esters of substituted 4-(pyridin-2-ylthio)- or 4-(1,4-dihydropyridin-2-ylthio)acetoacetic acids and hydrazine hydrate, were used in the synthesis of 6-amino-4-aryl-5-cyano-3-(pyridin-2-ylthiomethyl)-2,4-dihydropyrano[2,3-c]pyrazoles. The molecular and crystal structure of 6-amino-5-cyano-3-(3-cyano-4,6-dimethylpyridin-2-ylthiomethyl)-4-(2-nitrophenyl)-2,4-dihydropyrano[2,3-c]pyrazole was established by X-ray diffraction analysis. 相似文献
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二唑衍生物具有抗菌、消炎和调节植物生长等活性[1~5].二唑硫醚衍生物也具有一定抗菌活性[6].为筛选具有生物活性的新化合物和研究亲核取代反应的规律,我们设计和合成了新的2-酰肼基-5-(2,4-二氯苯基)-1,3,4-二唑2,研究了2在K2C... 相似文献
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通过3-苄基-4-芳酰基-1,2,4-三唑-5-巯基负离子在2-甲磺酰基-5-苯基-1,3,4-噁二唑环2-位上的亲核取代反应,制得13个新的(3-苄基-4-芳酰基-1,2,4-三唑-5-基)(5-苯基-1,3,4-噁二唑-2-基)硫醚衍生物.经元素分析、IR、~1H NMR和MS裂解碎片分析确认结构.初步观察了它们在0.01%浓度时对大肠杆菌繁殖的抑制作用. 相似文献
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Cyclization of 1-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-6-yl)carbonyl-4-R-thiosemicarbazides in basic medium gave 6-(4-R-5-thioxo-1,2,4-triazol-3-yl)pyrimidine-2,4-diones
(R = Allyl, Ph). Alkylation of the latter with iodomethane occurred at the sulphur atom to give the corresponding methylsulfanyl
derivatives. Acetylation using acetyl chloride occurred at the N(1) atom of the triazole ring to the corresponding acetyl derivative when R = Ph but for R = Allyl the acetylation did not occur
under the same conditions. In the presence of bromine in refluxing methanol the indicated allyl-substituted compound cyclizes
to 6-bromomethyl-3-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-6-yl)-5,6-dihydrothiazolo[2,3-c]-1,2,4-triazole. Under Mannich and
bromination conditions the methylsulfanyl derivatives prepared form derivatives at the 5 position of the uracil ring: 5-methylmorpholino-(piperidino)-and
5-bromo-(4-R-5-thioxo-1,2,4-triazol-3-yl)pyrimidine-2,4-diones respectively.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 6, pp. 906–912, June, 2006. 相似文献