气相色谱手性衍生化试剂N－七氟丁酰基－L－脯氨酰氯的合成与应用

 合成了用于气相色谱（ＧＣ）的手性衍生化试剂Ｎ－七氟丁酰基－Ｌ－脯氨酰氯（Ｎ－ＨＦＢ－Ｌ－ＰＣｌ）。各种特性试验表明，Ｎ－ＨＦＢ－Ｌ－ＰＣｌ是灵敏的ＧＣ手性衍生化试剂，可直接于水相拆分微量的手性胺对映体。     

RESOLUTION OF DL－α－AMINO ACIDS ON A L－HYDROXY PROLINE CHIRAL PHASE BY LIGAND－EXCHANGE CHROMATOGRAPHY

ＲＥＳＯＬＵＴＩＯＮＯＦＤＬ－α－ＡＭＩＮＯＡＣＩＤＳＯＮＡＬ－ＨＹＤＲＯＸＹＰＲＯＬＩＮＥＣＨＩＲＡＬＰＨＡＳＥＢＹＬＩＧＡＮＤ－ＥＸＣＨＡＮＧＥＣＨＲＯＭＡＴＯＧＲＡＰＨＹ￥ＴａｏＣＨＥＮ；ＴｉａｎＢａｏＨＵＡＮＧ（ＣｈｅｎｇｄｕＩｎｓｔｉｔｕｔ...     

FLUORESCENCE STUDIES ON SELF－ASSEMBLING BEHAVIOR OF AMPHIPHILES WITH NAPHALENE－1，5－DIOXY GROUP

ＦＬＵＯＲＥＳＣＥＮＣＥ　ＳＴＵＤＩＥＳ　ＯＮ　ＳＥＬＦ－ＡＳＳＥＭＢＬＩＮＧ　ＢＥＨＡＶＩＯＲ　ＯＦ　ＡＭＰＨＩＰＨＩＬＥＳ　ＷＩＴＨ　ＮＡＰＨＡＬＥＮＥ－１，５－ＤＩＯＸＹ　ＧＲＯＵＰＦＬＵＯＲＥＳＣＥＮＣＥＳＴＵＤＩＥＳＯＮＳＥＬＦ－ＡＳＳＥＭ...     

PREPARATION， ELECTRICAL PROPERTIES AND CRYSTAL STRUCTURE OF TWO NEW CHARGE－TRANSFER SALTS （BEDT－TTF）＿3Cu＿2Brx AND （TTM－TTF） （Cu＿2Bry） （y～4．72）

ＰＲＥＰＡＲＡＴＩＯＮ，　ＥＬＥＣＴＲＩＣＡＬ　ＰＲＯＰＥＲＴＩＥＳ　ＡＮＤ　ＣＲＹＳＴＡＬ　ＳＴＲＵＣＴＵＲＥ　ＯＦ　ＴＷＯ　ＮＥＷ　ＣＨＡＲＧＥ－ＴＲＡＮＳＦＥＲ　ＳＡＬＴＳ　（ＢＥＤＴ－ＴＴＦ）＿３Ｃｕ＿２Ｂｒｘ　ＡＮＤ　（ＴＴＭ－ＴＴＦ）　（...     

PREPARATION OF HETEROBIMETALLIC COMPLEXES BRIDGING WITH π，π－BOUND PHENYLCYCLOPENTADIENYL LIGAND AND X－RAY CRYSTAL STRUCTURE OF （TRICARBONYL－π－CHROMIUM）PHENYLCYCLOPENTADIENYLCOBALT DICARBONYL

ＰＲＥＰＡＲＡＴＩＯＮＯＦＨＥＴＥＲＯＢＩＭＥＴＡＬＬＩＣＣＯＭＰＬＥＸＥＳＢＲＩＤＧＩＮＧＷＩＴＨπ，π－ＢＯＵＮＤＰＨＥＮＹＬＣＹＣＬＯＰＥＮＴＡＤＩＥＮＹＬＬＩＧＡＮＤＡＮＤＸ－ＲＡＹＣＲＹＳＴＡＬＳＴＲＵＣＴＵＲＥＯＦ（ＴＲＩＣＡＲＢＯＮＹＬ...     

SYNTHESIS OF DI－（2＇－DEOXY－2＇－FLUORO）PYRIMIDINENUCLEOSIDE PHOSPHATES AND PHOSPHOROTIOATES

ＳＹＮＴＨＥＳＩＳＯＦＤＩ－（２＇－ＤＥＯＸＹ－２＇－ＦＬＵＯＲＯ）ＰＹＲＩＭＩＤＩＮＥＮＵＣＬＥＯＳＩＤＥＰＨＯＳＰＨＡＴＥＳＡＮＤＰＨＯＳＰＨＯＲＯＴＩＯＡＴＥＳＺｈｅｎｇＦｕＷＡＮＧ；ＹｉＢｉｎｇＺＨＡＮＧ；ＹａｏＱｕａｎＣＨＥＮ（Ｌａｂｏｒａ...     

THE BIRCH REDUCTION OF（1－OXO－CYCLOHEXENYLO）－2＇－［2＇，3＇，b］－6，7－MEHYLENEDIOXYBENZOZEPINE

ＴＨＥＢＩＲＣＨＲＥＤＵＣＴＩＯＮＯＦ（１－ＯＸＯ－ＣＹＣＬＯＨＥＸＥＮＹＬＯ）－２＇－［２＇，３＇，ｂ］－６，７－ＭＥＨＹＬＥＮＥＤＩＯＸＹＢＥＮＺＯＺＥＰＩＮＥＪｉａｎｇＨｏｎｇＷＡＮＧ；ＹｕｎＺｈｅｎＪＩＡＮＧ；ＺｈｉＺｈｏｎｇＺＨＡＯ（Ｉｎｓ...     

A NOVEL REACTION BETWEEN Ge－Ge AND Fe－Fe BONDS IN COMPLEX （Me_2GeGeMe_2）［（η~5－C_5H_4）Fe（CO）］_2（μ－CO）_2 AND CRYSTAL STRUCTURE OF THE PRODUCT

ＡＮＯＶＥＬＲＥＡＣＴＩＯＮＢＥＴＷＥＥＮＧｅ－ＧｅＡＮＤＦｅ－ＦｅＢＯＮＤＳＩＮＣＯＭＰＬＥＸ（Ｍｅ_２ＧｅＧｅＭｅ_２）［（η~５－Ｃ_５Ｈ_４）Ｆｅ（ＣＯ）］_２（μ－ＣＯ）_２ＡＮＤＣＲＹＳＴＡＬＳＴＲＵＣＴＵＲＥＯＦＴＨＥＰＲＯＤＵＣＴ￥ＸｉｕＴ?..     

PARAMAGNETIC AND DIAMAGNETIC DICOPPER（Ⅱ） COMPLEXES WITH DI－SCHIFF BASE DERIVED FROM 2－HYDROXY－1－NAPHTHALDEHYDE AND1，3－DIANINO－2－PROPANOL

ＰＡＲＡＭＡＧＮＥＴＩＣＡＮＤＤＩＡＭＡＧＮＥＴＩＣＤＩＣＯＰＰＥＲ（Ⅱ）ＣＯＭＰＬＥＸＥＳＷＩＴＨＤＩ－ＳＣＨＩＦＦＢＡＳＥＤＥＲＩＶＥＤＦＲＯＭ２－ＨＹＤＲＯＸＹ－１－ＮＡＰＨＴＨＡＬＤＥＨＹＤＥＡＮＤ１，３－ＤＩＡＮＩＮＯ－２－ＰＲＯＰＡＮＯＬ...     

FERROMAGNETICALLY COUPLED BINUCLEAR Fe（Ⅲ） COMPLEXES THROUGH ISOPHTHALATO－BRIDGE

ＦＥＲＲＯＭＡＧＮＥＴＩＣＡＬＬＹ　ＣＯＵＰＬＥＤ　ＢＩＮＵＣＬＥＡＲ　Ｆｅ（Ⅲ）　ＣＯＭＰＬＥＸＥＳ　ＴＨＲＯＵＧＨ　ＩＳＯＰＨＴＨＡＬＡＴＯ－ＢＲＩＤＧＥＦＥＲＲＯＭＡＧＮＥＴＩＣＡＬＬＹＣＯＵＰＬＥＤＢＩＮＵＣＬＥＡＲＦｅ（Ⅲ）ＣＯＭＰＬＥＸＥ...     

氯铬酸甲铵/硅胶载体氧化剂的制备及其对醇的氧化研究

利用硅胶作载体，负载氯铬酸甲铵盐制备了一种新的载体铬(Ⅵ)氧化剂。该试剂制备方法简单、性质稳定。可在多种反应介质中对伯醇和仲醇氧化，高收率得到相应的醛和酮，反应操作简单，提纯方便。     

o-Diamines as reagents for selenium : Part I. 4-dimethylamino-1,2-phenylenediamine

4-Dimethylamino-1,2-phenylenediamine is investigated as a photometric and qualitative reagent for selenium. With this reagent selenium (IV) forms 5-dimethylamino-2,1,3-benzoselenadiazole, a red colored compound, with an absorption maximum in the visible region at 500 mμ. Variables such as reagent stability, extinction stability, reaction rate, influence of acidity, foreign ions, validity of Beer's law are discussed. The reagent is highly selective for selenium, has good sensitivity and recproducibility, and is also useful for qualitative purposes.     

Studies in the analytical chemistry of sodium : 6:8-Dichlorobenzoylene urea as a reagent for sodium

6:8-Dichlorobcnzoylene urea has been. examined as a reagent for sodium. The reagent cannot be recommended for this purpose. Precipitation is incomplete and the reagent tends to hydrolyse so that it is impossible to differentiate sodium in the presence of potassium.     

氯铬酸三甲铵/氧化铝的制备及其对醇和苯偶姻类化合物的氧化

本文报道了氯铬酸三甲铵/氧化铝的制备方法及其对醇和苯偶姻类化合物的氧化反应。 该试剂制备简单、性质稳定。氧化反应条件温和、操作简单、提纯方便、收率良好。     

REALISIS: a medicinal chemistry-oriented reagent selection, library design, and profiling platform

REALISIS is a software system for reagent selection, library design, and profiling, developed to fit the workflow of bench chemists and medicinal chemists. Designed to be portable, the software offers a comprehensive graphical user interface and rapid, integrated functionalities required for reagent retrieval and filtering, product enumeration, and library profiling. REALISIS is component-based, consisting of four main modules: reagent searching; reagent filtering; library enumeration; and library profiling. Each module allows the chemist to access specific functionalities and diverse filtering and profiling mechanisms. By implementing the entire process of reagent selection, library design, and profiling and by integrating all the necessary functionalities for this process, REALISIS cuts the time required to design combinatorial and noncombinatorial libraries from several days to a few hours.     

Strained silacycles in organic synthesis: a new reagent for the enantioselective allylation of aldehydes

A new reagent for the enantioselective allylation of aliphatic aldehydes has been developed. The reagent is easily prepared in a single step from commercially available materials and may be stored without significant decomposition. The reactivity of the reagent is attributed to strain-release Lewis acidity.     

Chemically removable derivatization reagent for liquid chromatography I. 2-(N-Phthalimido)ethyl 2-(dimethylamino)ethanesulfonate

A sulfonate derivatization reagent, 2-(N-phthalimido)ethyl 2-(dimethylamino)ethanesulfonate, was synthesized and examined for use in liquid chromatography. The reagent contains two key moieties, a chromophore (phthalimido) necessary for detection and a dimethylamino function that is chemically removable after derivatization. The reagent was applied to the derivatization of 2,4,6-trichlorophenol as a model analyte. The results indicated that the reagent can be readily removed after derivatization by simple acid treatment.     

Staudinger/aza-Wittig reactions utilizing a novel linear polymer-supported triphenylphosphine as a modified liquid-phase reagent

A new triphenylphosphine reagent linked to a linear maleimide-styrene copolymer is synthesized and is found to be effective for the formation of a variety of imines via the Staudinger/aza-Wittig reaction. This linear polymer-supported triphenylphosphine has a unique solubility behavior and provides for a simple means of purifying the desired imine from the phosphine oxide by-product. The reactivity of this polymeric reagent is superior to that of the cross-linked polymer-supported phosphine reagent.     

Pulsed reagent introduction through a membrane reactor for flow-injection systems

A method of intermittent reagent introduction, functionally equivalent to stop-go pumping, is described. A pneumatically pressurized reagent reservoir is used to deliver liquid through a high-speed on/off valve to the outer channel of an annular tube assembly. Except for this single entry point, the outer channel is otherwise sealed. The inner flow channel bearing the principal flow stream contains a short microporous membrane tube. When the reagent delivery valve is activated, reagent flows radially inward through the membrane into the principal flow stream.     

Preparation and evaluation of a polymer-supported Mukaiyama reagent

The synthesis of a polymer-supported Mukaiyama reagent is described. This preparation was thoroughly optimized using a DoE approach to achieve optimum loading, and the procedure was successfully applied to prepare the supported reagent on a 10 g scale. This reagent proved to be effective for the formation of carbodiimides through the dehydration of thioureas and for a one-pot guanylation of primary amines.