共查询到20条相似文献,搜索用时 24 毫秒
1.
Klapötke TM Martin FA Stierstorfer J 《Chemistry (Weinheim an der Bergstrasse, Germany)》2012,18(5):1487-1501
1,5-Diaminotetrazole can be nitrated under very mild conditions by using nitronium tetrafluoroborate to result in 5-amino-1-nitriminotetrazole (1) in good yields. The same reaction can be performed with 1-amino-5-amino-4-methyltetrazole to yield 5-amino-4-methyl-1-nitriminotetrazole (2). Both compounds have been isolated and completely characterized by using vibrational spectroscopy, mass spectrometry, and differential scanning calorimetry. Additionally, X-ray diffraction measurements of the neutral compounds could be obtained; they indicated the structure of both compounds to be zwitterionic. Compounds 1 and 2 exhibit extremely high sensitivities to impact and friction and high positive heats of formation of 496 (1) and 453 kJ mol(-1) (2), respectively. Additionally, high-nitrogen-containing salts of 1 have been synthesized by metathesis reactions of silver 5-amino-1-nitriminotetrazolate with the corresponding halides so as to investigate the changes in sensitivity and thermal stability. All ionic compounds have been synthesized in good yields and characterized by means of vibrational and multinuclear NMR spectroscopy as well as X-ray diffraction measurements. Thermal stabilities have been evaluated by differential scanning calorimetry, whereas sensitivity measurements have been performed according to standardized Bundesanstalt für Materialforschung und -prüfung (BAM) tests. Theoretical calculations have been performed to investigate the heats of formation as well as the performance characteristics of the compounds. 相似文献
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NHE1(Na+/H+交换器1)抑制剂对于心肌缺血再灌注损伤具有较好的保护作用.以苯(或吡啶)甲酰胍为母核,利用拼合原理,在苯(或吡啶)甲酰胍母环上引入4-(2,3,4-三甲氧基苄基)哌嗪-1-甲基,设计并合成了8个未见文献报道的目标化合物.其结构经MS,IR,1H NMR和元素分析确证.体外血小板肿胀模型(PSA)试验结果表明,大部分目标化合物显示出较好的NHE1抑制活性. 相似文献
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对羟基桂皮酸甲酯和阿魏酸甲酯分别在氧化银催化下发生自由基仿生氧化偶联反应, 合成得苯并二氢呋喃环结构化合物1, 1经甲基化反应得2. 1a和1和2分别在无水碳酸钾、10%氢氧化钠水溶液等不同的碱性条件下进行反应, 获得了11个苯并二氢呋喃环开环产物, 即8-5’新木脂素类化合物3a~9b, 实现了由苯并二氢呋喃新木脂素向8-5’新木脂素的转变, 也为合成芪类化合物提供了一种新方法. C-8位上的吸电子基团如酯基的影响使苯并二氢呋喃环易在碱性条件下开环形成8-5’新木脂素类化合物.所合成化合物的结构由MS, IR, 1H NMR和13C NMR进行了表征. 相似文献
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Man Ge Jie Feng Hailian Huang Xiaofeng Gou Chengwen Hua Bang Chen Junlong Zhao 《Journal of heterocyclic chemistry》2019,56(12):3297-3302
Six novel derivatives of 2‐ferrocenyl‐5‐aryl‐1,3,4‐oxadiazoles have been synthesized through catalytic oxidation of benzoylhydrazone with nitrophthalocyanine iron (II) as catalyst and tert‐butyl hydroperoxide as oxidant. All of the compounds have been characterized by high‐resolution mass spectrometry, 1H, 13C NMR, and infrared spectroscopy. Moreover, the antifungal activities of all new compounds have been evaluated and the results showed that the compounds exhibited excellent antifungal activities. In addition, the molecular structure of compound 1c could also be determined by X‐ray single‐crystal diffraction. 相似文献
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Prof. Dr. Thomas M. Klapötke Dr. Burkhard Krumm Franz A. Martin Dr. Jörg Stierstorfer 《化学:亚洲杂志》2012,7(1):214-224
The treatment of triaminoguanidinium chloride with two equivalents of sodium nitrite under acidic conditions, followed by the cyclization with stoichiometric amounts of either sodium hydroxide solution or solid sodium carbonate yielded 1‐amino‐5‐azidotetrazole ( 1 ), 5‐azido‐1‐diazidocarbamoyltetrazole ( 2 ), and 1‐(aminoazidocarbamoyl)‐5‐azidotetrazole ( 3 ). The three novel compounds could be isolated by short‐column liquid chromatography by using chloroform in reasonable yields. The mechanism of the formation as well as the decomposition pathway of the materials was investigated and a full characterization of all three compounds is presented. Compounds 1 , 2 , 3 have been characterized by means of Raman and IR as well as multinuclear NMR spectroscopy, mass spectrometry, and X‐ray diffraction studies. Thermal stabilities have been evaluated by differential scanning calorimetry. Theoretical calculations have been performed to ensure the assignment of the vibrational modes obtained from Raman and IR measurements. The sensitivity values obtained from our measurements reflect the behavior of the compounds, which show an extremely high sensitivity toward mechanical as well as thermal stimuli. 相似文献
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DTA法是一种动态测量技术,可在程序变温情况下对给定物质或体系提供一个连续的、以温度或时间为函数的物性变化信息。通常测低温的熔点和相变用卡计,一般用样品20—30g。低温DTA只需1—3mg样品,而且一个样品可扫描出几个熔点。 相似文献
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Summary The separation of polar compounds by supercritical fluid chromatography is a difficult problem to solve. In this work, we have used a pre-derivatization method to obtain apolar or less polar compounds. Amino acids have been chosen as model polar compounds of biological interest, and 9-fluorenylmethyl chloroformate (FMOC) and (+)-1-(9-fluorenyl)ethyl chloroformate (FLEC) have been used as derivatizating reagents.With this procedure, the amino acids studied have been separated in less than 40 minutes with a good efficiency. Furthermore, with FLEC reagent, the enantiomeric separation was rapid in comparison with liquid chromatography techniques and the selectivities obtained were in the same order of magnitude. 相似文献
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E. H. Mamedbeyli I. A. Jafarov G. M. Talybov M. A. Mirzoeva K. O. Iskenderova A. N. Hajizade 《Russian Journal of General Chemistry》2017,87(4):713-716
New aminomethoxy derivatives of 1-(butylsulfanyl)pentane have been synthesized. The structure of the synthesized compounds was studied by elemental analysis, IR and 1Н NMR spectroscopy, and mass spectrometry. Some specimens of the synthesized compounds were tested as antimicrobial additives to lubricant oil, and as aseptic compounds against bacteria and fungi. 相似文献
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Serena Dotolo Carmen Cervellera Maria Russo Gian Luigi Russo Angelo Facchiano 《Molecules (Basel, Switzerland)》2021,26(2)
A computational screening for natural compounds suitable to bind the AKT protein has been performed after the generation of a pharmacophore model based on the experimental structure of AKT1 complexed with IQO, a well-known inhibitor. The compounds resulted as being most suitable from the screening have been further investigated by molecular docking, ADMET (Absorption, Distribution, Metabolism, Excretion, and Toxicity) analysis and toxicity profiles. Two compounds selected at the end of the computational analysis, i.e., ZINC2429155 (also named STL1) and ZINC1447881 (also named AC1), have been tested in an experimental assay, together with IQO as a positive control and quercetin as a negative control. Only STL1 clearly inhibited AKT activation negatively modulating the PI3K/AKT pathway. 相似文献
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Angla Schwartz Zoltn Pl Lszl Szab Klmn Simon Istvn Hermecz Zoltn Mszros 《Journal of heterocyclic chemistry》1987,24(3):645-650
Quinolizine compounds 1 and 2 or their monocyclic tautomers 3 and 4 have been synthesized using 2-pyri-dineacetic acid derivatives 6a, b, A, B and ethoxymethylenemalonic acid derivatives 7a, b, c in base catalyzed or thermic reaction. In the 6-unsubstituted series, both the 4-oxo and 4-imino derivatives could have been obtained, in the 6-substituted series, however the 4-oxo ones only, whereas instead of the 4-imino derivatives, their monocyclic tautomers 3, 4 have been isolated. In the 6-unsubstituted series, the primarily formed 4-imino compounds have been rearranged into 4-oxo ones under stronger conditions. The structure of the isolated compounds have been proved by ultraviolet, infrared and 1H nmr spectra, that of 3B=C by X-ray analysis as well. 相似文献
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The rational design of new sensitive materials for chemical sensors relies on the knowledge of molecular interactions between the chemical species in question with compounds that may potentially be present in the gas phase. In this context, the intermolecular interactions between a family of functionalized polysiloxanes and a series of organic compounds have been investigated. This work addresses the problem of determining the association constant or energy by studying neat liquid mixtures without solvents. An original approach has been proposed to obtain such information from the excess function of the difference in chemical shifts between both interacting species. Data obtained as a function of the composition of the mixtures have been fitted according to two models: either by considering the formation of a 1:1 complex governed by an equilibrium constant or by the existence of a local composition following the Wilson model. Both methods have been tested on model compounds and the results have been compared with solubility enthalpies calculated using Hansen coefficients. 相似文献
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Malformations in shellfish have been reported by many authors. They attributed the cause of the deformity to the presence in water of organotin compounds used in the formulation of antifouling paints, for example bis(tributyltin) oxide (TBTO) and tributyltin chloride (TBTC). The behaviour of these compounds has been examined under abiotic laboratory conditions. The influence of many parameters such as sunlight, pH, oxygen, salinity have been examined. The degradation compounds obtained have been identified: (1) In the gas phase two major products, butene-1 and buetene-2, are observed with consumption of oxygen; (2) In the liquid phase, three main products are obtained, butanol-1, butanol-2 and butanone 2. The identified products represent a small part of the total concentration, suggesting a competing process such as formation of butyltin polymers; (3) In fresh water an amorphous solid phase is observed while in seawater a white cristalline precipitate appears. 相似文献
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Shabana Khatoon Ashok K. Yadav 《Phosphorus, sulfur, and silicon and the related elements》2013,188(2):345-352
Some new nucleosides, viz. 4-imino-3,5,7-trisubstituted-1-(2′,3′,5′-tri-O-kbenzyl–β-D-ribofuranosyl)pyrido[2,3-d]pyrimidin/e–2(1H)-ones/ thiones(VII/VIII), have been synthesized by condensation of trimethylsilyl derivatives of 4-imino-3,5,7-trisubstituted pyrido[2,3-d]pyrimidin/e-2(1H)-ones/thiones (III/IV) with β-D-ribofuranosyl1-acetate-2,3,5-tribenzoate. Compounds III/IV have been synthesized by refluxing 2-amino-3-cyano-4,6-disubstituted pyridine (II) with substituted an arylisocyanate or an isothiocyanate respectively. The structure of all the synthesized compounds have been established by IR and 1H NMR studies. These compounds have been screened for antimicrobial activities in order evaluate. The possibility of the derivatives to be used as potential chemotherapeutic agents. 相似文献
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Three homologous series of banana-shaped five-ring esters and one series of seven-ring esters derived from 2-methylresorcinol have been synthesized. This has been carried out to understand the effect of chemical structure on the mesomorphic properties of such compounds. It is shown that the 2-methyl substituent in the central phenyl ring destabilizes the mesophases when they are compared with those of the analogous unsubstituted compounds. Replacement of a phenyl ring by a biphenyl moiety (seven-ring esters) in the two arms of the bent-core molecule enhances the thermal range of the mesophases as well as the clearing temperatures. The mesophases have been characterized using techniques such as polarizing optical microscopy, differential scanning calorimetry, and X-ray diffraction, and by electro-optical investigations. In the 32 compounds investigated, two mesophases, B 1 and B 2 , have been identified. 相似文献
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A series of novel and synthetically important quinoline selenium compounds have been successfully synthesized using an efficient and simple strategy. The method employed leads to the synthesis of both cyclic as well as open chain quinoline selenium compounds. The prepared selenium compounds have been characterized with the help of various spectroscopic techniques viz., NMR (1H, 13C), FT-IR, mass spectrometry. The structure of 6-methoxy-3H-[1,2]diselenolo[3,4-b]quinoline has been determined by X-ray crystallography. 相似文献