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在氟化钾作催化剂和四氢呋喃作溶剂的条件下,研究了系列脂肪胺亲核试剂与5-烷氧基-3,4-二卤-2(5H)-呋喃酮发生的反应,通过旋光度,UV-Vis,IR,1H NMR,13C NMR,MS,元素分析和X射线单晶衍射等表征方法对产物进行结构表征,发现通常情况下发生预期的串联迈克尔加成-消除反应,合成了13个新的β-胺基-2(5H)-呋喃酮.但是,空间位阻较大的二环己基胺与5-烷氧基-3,4-二卤-2(5H)-呋喃酮反应时,却得到了4个异常的2(5H)-呋喃酮开环产物,其可能是经开环重排反应的机理得到的. 相似文献
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为了深入探索5-烷氧基-3,4-二卤-2(5H)-呋喃酮与胺类试剂发生的反应,进一步在氟化钾作催化剂和四氢呋喃作溶剂的条件下,研究了其与系列不饱和胺的反应,通过旋光度,UV-Vis,IR,1H NMR,13C NMR,MS,元素分析和X射线单晶衍射等表征方法对产物进行结构表征,发现大多数情况下发生预期的串联迈克尔加成-消除反应,得到了16个新的β-胺基-2(5H)-呋喃酮化合物.当不饱和胺为空间位阻较大的2,5-二甲基-3-吡咯啉时,与位阻较大的5-孟氧基-3,4-二卤-2(5H)-呋喃酮反应只是生成异常的2(5H)-呋喃酮开环产物,而与位阻较小的5-甲氧基-3,4-二卤-2(5H)-呋喃酮反应则既有正常的β-胺基-2(5H)-呋喃酮产物,也有经开环重排反应的机理得到的异构体产物.后者表明,底物的位阻大小也是影响反应的因素,甚至导致同时存在竞争反应. 相似文献
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用溶液法合成了4-(4′-吡啶)-1,3-二硫代环戊烯-2-酮(C8H5NOS2)与铜(Ⅱ)的配合物,并得到了单晶.通过红外光谱、元素分析和X射线单晶衍射分析对配合物的组成和结构进行了表征.X射线单晶衍射分析表明:配合物属三斜晶系,空间群P-1,是由2个CuSO4、4个配体C8H5NOS2分子、2个配位H2O和6个游离的H2O组成的双核配合物.配合物分子通过S…S短程作用形成了1个二维层状结构,并通过分子间的氢键作用进一步形成了更稳定的三维结构. 相似文献
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The title compounds were synthesized and characterized by IR,1H-NMR,Mass and elementary analysis and single-crystal X-ray diffraction.In 1a,intermolecular C-H…π interactions produce a three-dimensional network.In 1b,intermolecular C-H…O hydrogen bonds generate an R22(22) ring.The hydrogen bonding is supported by C-H…π interactions. 相似文献
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The molecular structure of 2,4-diacetyl-3-(2-chlorophenyl)-5-hydroxy-5-methyl-N-(4-methylphenyl)-1-cyclohexenylamine (Ia) determined by X-ray diffractometry (XRD) is described. Two intramolecular hydrogen bonds: O-H…O=C and N-H…O=C are realized in molecule Ia. 相似文献
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1INTRODUCTIONSeveralimportantapproachestothesynthesisandpropertiesofchiralγ alkyloxybutenolideshaveatractedmuchatentionowingt... 相似文献
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1INTRODUCTIONOwingtotheirwideoccurenceinavarietyofbiologicalyactivenaturalproductsandtheirutilityasvaluablesyntheticintermedi... 相似文献
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LI Xun XU Wen-Fang ② 《结构化学》2005,24(6):706-710
1 INTRODUCTION Aminopeptidase N (APN), a member of mem- brane-bound zinc-dependent exopeptidase, is known to be high expression on the brush border membran- es of the small intestine and renal proximal tubules[1]. The over-expression of APN has been involved in several pathological conditions including cancer[2], leukemia, diabetic nephropathy[3], rheumatoid arth- ritis[4], angiogenesis[5] and central nervous system di- seases, such as Alzheimer’s disease[6]. This has led to the sear… 相似文献
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1INTRODUCTION Isoxazole derivatives are an important class of heterocycles as intermediates for natural product synthesis and building blocks for constructing new molecular systems[1,2].In addition,isoxazole deriva-tives have been long targeted in synthetic inves-tigation for their known biological activities and pharmacological properties such as hypoglycemic,analgesic,anti-inflammatory and anti-bacterial acti-vities[3~6].Therefore,the isoxazolines and isoxazoles with phosphonate group ar… 相似文献
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XU Liang-Zhong BI Wen-Zhao YANG Zhi MENG Fan-Lei ZHU Qi 《结构化学》2008,27(11):1365-1369
The title compound 1-((5-(4-(4-chlorophenoxy)-2-chlorophenyl)-2,2,3-trimethyl-oxazolidin- 5-yl)methyl)-lH-1,2,4-triazole (C21H22Cl2N4O2)has been synthesized and characterized by elemental analysis, IR, 1H NMR, MS and single-crystal X-ray diffraction. The crystal belongs to the triclinic system, space group Pi with a = 6.891(2), b = 9.074(2), c = 18.258(4)AA, α = 99.292(4), β = 95.105(4), γ = 108.068(3)°, C21H22Cl2N4O2, Mr = 433.33, V= 1059.3(4) Aa, Z = 2, Dc = 1.359 g/cm3, F(000) = 452,μ = 0.331 mm-1, the final R = 0.0448 and wR = 0.0994 for 3727 unique reflections. The dihedral angle between the oxazolidine ring taking an envelope conformation with a local pseudo-mirror and the triazole ring is 27.7(9)°. Weak intermolecular C-H...N hydrogen bonds and π-π interactions exist between the triazole rings of neighboring molecules, forming a three-dimensional network, which stabilizes the crystal structure. The primary biological test shows the target compound has certain fungicidal activity. 相似文献
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1INTRODUCTIONInorganicsolidsupportsascatalystshavebeenwellstudied,becauseoftheirap-plicationsinorganicsynthese('~".Recently,wehavereportedtheKnoevenagelcon-densationcatalysedbyKF-Al,O,['i.Inthispaper,wediscussedthecrystalstruc-tureofthetitlecomPoundsynthesizedbythereactionof2-chlorobenzaldehydey5,5-dimethyl-1,3-cyclohexanedioneandisopropylidenemalonateinmethanolcatalyzedbyKF-Alzo,'Inordertoconfirmthestructureofthetitlecompound,theX-raycrys-tallOgraphicstudywascarriedout.2EXPER1MEN… 相似文献