融入统筹理念的分析化学实验教学

基于一流创新人才培养的要求和分析化学实验课程的特点,介绍了如何在分析化学实验教学中融入统筹学理念,旨在培养学生的统筹能力,拓展化学实验课程的育人功能,实现知识技能传授和综合能力培养并重的教学目的,将创新人才培养的教学理念落到实处。     

基于雨课堂和BOPPPS改进模型的教学设计——以大学化学课程为例

在高等学校专业课程教学中融入思政教育教学的理念,是以"立德树人"为教育根本任务的基本要求。结合结构化学课程特点和教学内容,以"培养学生的哲学观和科学观、培养学生民族自豪感和自信心"的目标为切入点,提出结构化学教学中思政元素的融入策略,发挥结构化学课程的"育德功能",实现知识传授和价值引领的有机统一。     

创评奥运五环的趣味实验

创意教学行为是符合新课程改革的一种新型教学行为[1]。奥运五环实验就是以众人皆知的奥运五环图案为基本框架,将化学知识有机地融入其中,展示化学美、呈现化学真、感受化学亲的富有创新思想的趣味创意实验。它能充分激发起学生的探究兴趣、求知欲望;营造了乐于创新的教学情境;优化和提升了教学效果;丰富了教学资源。     

化学史融入初中化学教学现状的调查与对策研究

为了准确掌握内蒙古地区化学史融入初中化学实际教学的现状与不足。研究选取内蒙古地区10所初中的603名学生和38所初中的113名初中化学教师进行了问卷调查。结果表明内蒙古初三学生对化学史有较浓厚的兴趣,渴望通过化学史知识的学习激发学习化学的兴趣、理清知识脉络、提高创新探究能力、学会科学研究方法,而当前化学教学中存在化学史教学方法单一、化学史融入教学的程度较低、应试教育严重限制化学史教学的开展等诸多问题。针对存在的问题,研究提出化学史融入中学化学教学的"四线式"教学模式,以期改观内蒙古地区化学史融入初中化学实际教学的现状。     

传统文化融入中学化学教学——“非遗印染技艺”的教学资源开发

从染料的利用历史、传统印染工艺、印染环保创新等3个维度挖掘了非遗印染技艺的教学资源，与萃取、自然资源开发利用、还原剂、硫及其化合物、酚醇性质、配合物、电解池等化学知识结合，以印染技艺为载体将传统文化、思政教育与化学教学有机融合，落实化学学科核心素养的发展，为传统文化融入中学化学教学提供借鉴。     

军事后勤专业大学化学教学研究

大学化学"是军事后勤专业的基础课,为武警后勤保障中化学问题解决提供基础。从教学内容、教学模式、教学评价等方面进行了研究,以期学员能运用化学理论分析和解决军事装备、军事工程和后勤保障中的化学难题。     

关于无机化学适应性教学的思考

当今社会,化学已悄然融入社会、技术和科学的各个领域,并且正在潜移默化地影响、改变着我们周围的世界和生活。根据21世纪对人才的知识结构、能力结构和基本素质要求,基础化学教育的任务,应摒弃传统的单纯的具体知识的传授,更多地应是侧重学生素质和能力的培养,强调科学思维、科学素质和创新精神,并将世界观、方法论的教育,智力和能力的提高融合于日常的教学中。化学学科中发展最早的一门分支科学——无机化学,是化工学院学生的第一门专业基础课。     

无机化学课程思政探索——以“配位化学基础”中部分内容的教学设计为例

课程思政是将思想政治教育元素融入课程教学,深化专业课程教书育人的内涵。在教学过程中,以基础理论知识为主线,融入化学发展史、化学家的主要贡献、化学学科和生产生活的紧密联系以及当代科技研究前沿等内容,构建无机化学课程思政教学体系。本文以配位化学基础中部分内容的教学设计为例,对思政案例进行介绍。     

知识体系构建的本科教学实践

结合厦门大学本科分析化学基础课程的教学实践,对如何在本科基础课程教学中融入知识处理和学科知识体系一体化构建进行了初浅的探讨。提出了一种基于识别诱导信号激励与信号传感的化学测量一体化知识体系,并结合多元化创新思维教学案例对其教学意义进行了探讨。     

开放课堂利用实验探究学习新知识的探讨——"铁化合物及亚铁化合物的相互转化"的教学案例

化学教学的主旨是通过教学把人类已有的化学科学知识变成学生自己的知识,并进一步转化为学生发现、探究和解决新问题的能力。要十分注重中学化学实验的教育功能,重视化学实验及化学实验教学的设计,以培养学生的化学实践能力和创新精神。新一轮课程改革要求在教学中强化实验的功能,改变以往实验只是起演示和辅助作用的状况;在学生探究实验中,必须注意激发学生的兴趣,注重培养学生的创新意识、实验能力、科学方法和合作精神。     

A carbanion induced synthesis of highly congested pyrazole and imidazole containing heterocycles

An efficient approach to the synthesis of highly congested di, penta and hexacyclic pyrazoles as well as imidazole fragment containing novel heterocyclic molecule has been developed through a carbanion induced transformation of suitably functionalized 2H-pyran-2-ones, benzo[h]chromene and thiochromeno[4,3-b]pyrans. Due to the presence of fluorescence, we report their prime application metal sensor as off/on switching in ferric ions.     

α-Amino acid derived enaminones and their application in the synthesis of N-protected methyl 5-substituted-4-hydroxypyrrole-3-carboxylates and other heterocycles

A new and simple synthesis of novel N-protected methyl 5-substituted-4-hydroxypyrrole-3-carboxylates, which exist in equilibrium with their 4-oxo tautomers, has been developed in two steps starting from N-protected α-amino acids. The key intermediates are enaminones, which can also be isolated, characterized, and used for the construction of other functionalized heterocycles, before they spontaneously decompose to pyrrole products. 4-Hydroxypyrroles are prone to partial aerial oxidation but can be efficiently alkylated or reduced to stable polysubstituted pyrrolidine derivatives.     

Specific intramolecular aromatic CH insertion of diazosulfonamides

The chemoselectivity in the intramolecular CH insertion of various diazosulfonamides has been experimentally studied. The results reveal that the aliphatic 1,4-, 1,5-, or 1,6-C(sp³)?H insertions of diazosulfonamides are not accessible, while the aromatic 1,5-C(sp²)?H insertion can be realized specifically by adjusting the diazo-adjacent group. In addition, the general chemoselectivities in the intramolecular CH insertions of diazosulfonyl compounds are summarized. Generally, diazosulfones undergo both aromatic 1,5-C(sp²)?H and aliphatic 1,5- and 1,6-C(sp³)?H insertions, while diazosulfonates undergo aliphatic 1,5- and 1,6-C(sp³)?H insertions. However, diazosulfonamides only undergo aromatic 1,5-C(sp²)?H insertion.     

N-Heterocyclic carbene-palladacyclic complexes: synthesis,characterization and their applications in the C-N coupling and α-arylation of ketones using aryl chlorides

N-Heterocyclic carbene-palladacyclic complexes 3 were successfully achieved in a one-pot procedure under mild conditions. The structure of 3a was unambiguously confirmed by X-ray single crystal diffraction and it was an active catalyst in the Buchwald-Hartwig amination and α-arylation of ketones even at very low catalyst loadings (0.01?mol%).     

Selective synthesis of 4,5-dihydroimidazo- and imidazo[1,5-a]quinoxalines via modified Pictet–Spengler reaction

An efficient tandem approach for the selective synthesis of 4,5-dihydroimidazo[1,5-a]quinoxalines 6a–g and imidazo[1,5-a]quinoxalines 7a–h by the reaction of 2-imidazolyl anilines 4a–c with aryl aldehydes 5a–k under mild reaction conditions is described. Introduction of electron releasing alkyl groups in substrates 4a–b was found to be instrumental for the success of the reaction.     

Understanding the Diels-Alder reactivity of 1,2-azaborine analogues

The Diels-Alder reactivity of 1,2-heteroborines (H₄C₄B(H)X, X?=?NH, PH, AsH; O, S, Se) has been computationally explored by means of Density Functional Theory (DFT) calculations. The influence of the HB?=?X fragment on the reactivity of the system has been quantitatively analyzed in detail by means of the so-called Activation Strain Model (ASM) of reactivity. It is found that the interaction between these species and the dienophile is significantly stronger than that computed for their all-carbon isoelectronic counterpart, benzene. In addition, the strain energy plays a key role in the observed reactivity trends. The role of the aromaticity strength of these heteroarenes on the reactivity is also assessed.     

Synthesis of N-substituted carbazolones from α-iodo enaminones via Pd(0)-catalyzed intramolecular coupling under microwave irradiation

A variety of N-aryl and N-alkyl carbazolones were conveniently achieved in good to high yields via Pd₂(dba)₃-mediated intramolecular coupling of N-substituted α-iodo enaminones under microwave irradiation. The Pd(0)-catalyzed cyclization was found to proceed favorably with the more electron-deficient phenyl ring during the reactions involving unsymmetrical N,N-diaryl α-iodo enaminones. This unique property enables the construction of carbazolone skeleton containing nitro substituted benzenoid ring.     

Iodine-mediated oxidative Pictet-Spengler reaction using terminal alkyne as the 2-oxoaldehyde surrogate for the synthesis of 1-aroyl-β-carbolines and fused-nitrogen heterocycles

An efficient iodine-mediated oxidative Pictet-Spengler reaction in dimethyl sulphoxide (DMSO) using terminal alkynes as the 2-oxoaldehyde surrogate for the synthesis of aryl (9H-pyrido[3,4-b]indol-1-yl)methanones is described. The scope of the protocol includes the total synthesis of Fascaplysin, Eudistomins Y₁ and Y₂. The methodology is extended for preparing pyrrolo[1,2-a]-quinoxaline and indolo[1,5-a]quinoxaline derivatives. The utility of 1-aroyl-β-carbolines was demonstrated by performing palladium-catalyzed β-carboline directed ortho-C(sp2)-H functionalization of the phenyl ring with thiomethyl (SMe) group using DMSO as source and for accessing 4-aryl-canthin-6-ones.     

Facile synthesis of bicyclic 1-arylpyrazol-5-ones

In this Letter, we described a facile method for constructing fused bicyclic 1-arylpyrazol-5-one ring system. We employed various methylene-containing carboxylic acids as the substrates and proved that the pyrazolone ring closure requires activated methylene group in intermediate II. Accordingly, a series of structurally diversified, fused bicyclic 1-arylpyrazol-5-ones was prepared in moderate to high yields using the requisite substrates.     

Synthesis of substituted 2,4,5,6-tetrahydrocyclopenta[c]pyrazoles and 2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazoles by intramolecular nitrilimine cycloaddition

Both substituted 2,4,5,6-tetrahydrocyclopenta[c]pyrazoles and 2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazoles have been synthesized by the 3+2 intramolecular dipolar cycloaddition of nitrilimines to alkynes. This cyclization has been extended to more versatile 3-bromo derivatives by the use of alkynylbromides as dipolarophiles.