A class of transformation rate models for recurrent event data

Recurrent event data frequently occur in longitudinal studies, and it is often of interest to estimate the effects of covariates on the recurrent event rate. This paper considers a class of semiparametric transformation rate models for recurrent event data, which uses an additive Aalen model as its covariate dependent baseline. The new models are flexible in that they allow for both additive and multiplicative covariate effects, and some covariate effects are allowed to be nonparametric and time-varying. An estimating procedure is proposed for parameter estimation, and the resulting estimators are shown to be consistent and asymptotically normal. Simulation studies and a real data analysis demonstrate that the proposed method performs well and is appropriate for practical use.     

Efficient estimation for semiparametric varying- coefficient partially linear regression models with current status data

This article considers a semiparametric varying-coefficient partially linear regression model with current status data. The semiparametric varying-coefficient partially linear regression model which is a generalization of the partially linear regression model and varying-coefficient regression model that allows one to explore the possibly nonlinear effect of a certain covariate on the response variable. A Sieve maximum likelihood estimation method is proposed and the asymptotic properties of the proposed estimators are discussed. Under some mild conditions, the estimators are shown to be strongly consistent. The convergence rate of the estimator for the unknown smooth function is obtained and the estimator for the unknown parameter is shown to be asymptotically efficient and normally distributed. Simulation studies are conducted to examine the small-sample properties of the proposed estimates and a real dataset is used to illustrate our approach.     

Statistical inference for panel data semiparametric partially linear regression models with heteroscedastic errors

We consider a panel data semiparametric partially linear regression model with an unknown parameter vector for the linear parametric component, an unknown nonparametric function for the nonlinear component, and a one-way error component structure which allows unequal error variances (referred to as heteroscedasticity). We develop procedures to detect heteroscedasticity and one-way error component structure, and propose a weighted semiparametric least squares estimator (WSLSE) of the parametric component in the presence of heteroscedasticity and/or one-way error component structure. This WSLSE is asymptotically more efficient than the usual semiparametric least squares estimator considered in the literature. The asymptotic properties of the WSLSE are derived. The nonparametric component of the model is estimated by the local polynomial method. Some simulations are conducted to demonstrate the finite sample performances of the proposed testing and estimation procedures. An example of application on a set of panel data of medical expenditures in Australia is also illustrated.     

Efficient estimation of a varying-coefficient partially linear binary regression model

This article considers a semiparametric varying-coefficient partially linear binary regression model. The semiparametric varying-coefficient partially linear regression binary model which is a generalization of binary regression model and varying-coefficient regression model that allows one to explore the possibly nonlinear effect of a certain covariate on the response variable. A Sieve maximum likelihood estimation method is proposed and the asymptotic properties of the proposed estimators are discussed. One of our main objects is to estimate nonparametric component and the unknowen parameters simultaneously. It is easier to compute, and the required computation burden is much less than that of the existing two-stage estimation method. Under some mild conditions, the estimators are shown to be strongly consistent. The convergence rate of the estimator for the unknown smooth function is obtained, and the estimator for the unknown parameter is shown to be asymptotically efficient and normally distributed. Simulation studies are carried out to investigate the performance of the proposed method.     

A semiparametric additive rates model for clustered recurrent event data

Recurrent event data often arises in biomedical studies, and individuals within a cluster might not be independent. We propose a semiparametric additive rates model for clustered recurrent event data, wherein the covariates are assumed to add to the unspecified baseline rate. For the inference on the model parameters, estimating equation approaches are developed, and both large and finite sample properties of the proposed estimators are established.     

Regression analysis of multivariate recurrent event data with time-varying covariate effects

Recurrent event data occur in many fields and many approaches have been proposed for their analyses (Andersen et al. (1993) [1]; Cook and Lawless (2007) [3]). However, most of the available methods allow only time-independent covariate effects, and sometimes this may not be true. In this paper, we consider regression analysis of multivariate recurrent event data in which some covariate effects may be time-dependent. For the problem, we employ the marginal modeling approach and, especially, estimating equation-based inference procedures are developed. Both asymptotic and finite-sample properties of the proposed estimates are established and an illustrative example is provided.     

Estimation in partially linear models with missing responses at random

A partially linear model is considered when the responses are missing at random. Imputation, semiparametric regression surrogate and inverse marginal probability weighted approaches are developed to estimate the regression coefficients and the nonparametric function, respectively. All the proposed estimators for the regression coefficients are shown to be asymptotically normal, and the estimators for the nonparametric function are proved to converge at an optimal rate. A simulation study is conducted to compare the finite sample behavior of the proposed estimators.     

Empirical likelihood for heteroscedastic partially linear models

We make empirical-likelihood-based inference for the parameters in heteroscedastic partially linear models. Unlike the existing empirical likelihood procedures for heteroscedastic partially linear models, the proposed empirical likelihood is constructed using components of a semiparametric efficient score. We show that it retains the double robustness feature of the semiparametric efficient estimator for the parameters and shares the desirable properties of the empirical likelihood for linear models. Compared with the normal approximation method and the existing empirical likelihood methods, the empirical likelihood method based on the semiparametric efficient score is more attractive not only theoretically but empirically. Simulation studies demonstrate that the proposed empirical likelihood provides smaller confidence regions than that based on semiparametric inefficient estimating equations subject to the same coverage probabilities. Hence, the proposed empirical likelihood is preferred to the normal approximation method as well as the empirical likelihood method based on semiparametric inefficient estimating equations, and it should be useful in practice.     

Sieve M-estimation for semiparametric varying-coefficient partially linear regression model

This article considers a semiparametric varying-coefficient partially linear regression model.The semiparametric varying-coefficient partially linear regression model which is a generalization of the partially linear regression model and varying-coefficient regression model that allows one to explore the possibly nonlinear effect of a certain covariate on the response variable.A sieve M-estimation method is proposed and the asymptotic properties of the proposed estimators are discussed.Our main object is to estimate the nonparametric component and the unknown parameters simultaneously.It is easier to compute and the required computation burden is much less than the existing two-stage estimation method.Furthermore,the sieve M-estimation is robust in the presence of outliers if we choose appropriate ρ( ).Under some mild conditions,the estimators are shown to be strongly consistent;the convergence rate of the estimator for the unknown nonparametric component is obtained and the estimator for the unknown parameter is shown to be asymptotically normally distributed.Numerical experiments are carried out to investigate the performance of the proposed method.     

Time-varying latent model for longitudinal data with informative observation and terminal event times

Longitudinal data often occur in follow-up studies, and in many situations, there may exist informative observation times and a dependent terminal event such as death that stops the follow-up. We propose a semiparametric mixed effect model with time-varying latent effects in the analysis of longitudinal data with informative observation times and a dependent terminal event. Estimating equation approaches are developed for parameter estimation, and asymptotic properties of the resulting estimators are established. The finite sample behavior of the proposed estimators is evaluated through simulation studies, and an application to a bladder cancer study is provided.     

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??In this paper, semiparametric estimation of a regression function in the third order partially linear autoregressive model with first order autoregressive errors is mainly studied. We suppose that the regression function has a parametric framework, and use the conditional least squares method to obtain the parameter estimators. Then semiparametric estimators of the regression function can be given by combining with the nonparametric kernel function adjustment. Furthermore, under certain conditions, the consistency of the estimators is proved. Finally, simulation research is presented to evaluate the effectiveness of the proposed method.     

多类型复发事件下变系数加性乘积比率回归模型

本文基于多类型复发事件数据,讨论了一个新的加性乘积比率回归模型,该模型包括两部分,其中第一部分为可加Aalen模型,其中协变量影响为加性的且与时间有关.第二部分为Cox回归模型,其中协变量有乘性影响.利用估计方程的方法,给出了该模型中未知参数和非参数函数的一种估计方法,并利用现代经验过程理沦证明了所得估计的相合性和渐近正态性.     

成组复发事件下的半参数变换模型

本文在成组复发事件下研究了一个一般半参数的边际变换模型,利用估计方程的理论,给出了该模型中未知参数和基本比率函数的估计,同时利用现代经验过程理论证明了所得估计的相合性和渐近正态性.     

半参数变系数部分线性模型的统计推断

本文在多种复杂数据下, 研究一类半参数变系数部分线性模型的统计推断理论和方法. 首先在纵向数据和测量误差数据等复杂数据下, 研究半参数变系数部分线性模型的经验似然推断问题, 分别提出分组的和纠偏的经验似然方法. 该方法可以有效地处理纵向数据的组内相关性给构造经验似然比函数所带来的困难. 其次在测量误差数据和缺失数据等复杂数据下, 研究模型的变量选择问题, 分别提出一个“纠偏” 的和基于借补值的变量选择方法. 该变量选择方法可以同时选择参数分量及非参数分量中的重要变量, 并且变量选择与回归系数的估计同时进行. 通过选择适当的惩罚参数, 证明该变量选择方法可以相合地识别出真实模型, 并且所得的正则估计具有oracle 性质.     

Variable selection for semiparametric varying-coefficient partially linear models with missing response at random

In this paper, we present a variable selection procedure by combining basis function approximations with penalized estimating equations for semiparametric varying-coefficient partially linear models with missing response at random. The proposed procedure simultaneously selects significant variables in parametric components and nonparametric components. With appropriate selection of the tuning parameters, we establish the consistency of the variable selection procedure and the convergence rate of the regularized estimators. A simulation study is undertaken to assess the finite sample performance of the proposed variable selection procedure.     

半参数混合效应模型中的估计及其强相合性

将Tao等(1999)提出的线性混合效应模型推广为半参数混合效应模型,给出了模型参数、回归函数和随机效应密度的估计,并研究了估计的强相合性及部分强相合速度.统计模拟表明我们给出的估计方法是可行的.     

STRONG CONVERGENCE RATES OF SEVERAL ESTIMATORS IN SEMIPARAMETRIC VARYING-COEFFICIENT PARTIALLY LINEAR MODELS

This article is concerned with the estimating problem of semiparametric varyingcoefficient partially linear regression models. By combining the local polynomial and least squares procedures Fan and Huang （2005） proposed a profile least squares estimator for the parametric component and established its asymptotic normality. We further show that the profile least squares estimator can achieve the law of iterated logarithm. Moreover, we study the estimators of the functions characterizing the non-linear part as well as the error variance. The strong convergence rate and the law of iterated logarithm are derived for them, respectively.     

An additive-multiplicative rates model for multivariate recurrent events with event categories missing at random

Multivariate recurrent event data arises when study subjects may experience more than one type of recurrent events. In some situations, however, although event times are always observed, event categories may be partially missing. In this paper, an additive-multiplicative rates model is proposed for the analysis of multivariate recurrent event data when event categories are missing at random. A weighted estimating equations approach is developed for parameter estimation, and the resulting estimators are shown to be consistent and asymptotically normal. In addition, a model-checking technique is presented to assess the adequacy of the model. Simulation studies are conducted to evaluate the finite sample behavior of the proposed estimators, and an application to a platelet transfusion reaction study is provided.     

基于纵向数据的半参数变系数部分线性回归模型

纵向数据是数理统计研究中的复杂数据类型之一0,在生物、医学和经济学中具有广泛的应用．在实际中经常需要对纵向数据进行统计分析和建模．文章讨论了纵向数据下的半参数变系数部分线性回归模型,这里的纵向数据的在纵向观察在时间上可以是不均等的,也可看成是按某一随机过程来发生．所研究的半参数变系数模型包括了许多半参数模型,比如部分线性模型和变系数模型等．利用计数过程理论和局部线性回归方法,对于纵向数据下半参数变系数进行了统计推断,给出了参数分量和非参数分量的profile最小二乘估计,研究了这些估计的渐近性质,获得这些估计的相合性和渐近正态性．     

A generalized partially linear framework for variance functions

When model the heteroscedasticity in a broad class of partially linear models, we allow the variance function to be a partial linear model as well and the parameters in the variance function to be different from those in the mean function. We develop a two-step estimation procedure, where in the first step some initial estimates of the parameters in both the mean and variance functions are obtained and then in the second step the estimates are updated using the weights calculated based on the initial estimates. The resulting weighted estimators of the linear coefficients in both the mean and variance functions are shown to be asymptotically normal, more efficient than the initial un-weighted estimators, and most efficient in the sense of semiparametric efficiency for some special cases. Simulation experiments are conducted to examine the numerical performance of the proposed procedure, which is also applied to data from an air pollution study in Mexico City.