Multivariate Failure Times Regression with a Continuous Auxiliary Covariate

How to take advantage of the available auxiliary covariate information when the primary covariate of interest is not measured is a frequently encountered question in biomedical study. In this paper, we consider the multivariate failure times regression analysis in which the primary covariate is assessed only in a validation set, but a continuous auxiliary covariate for it is available for all subjects in the study cohort. Under the frame of marginal hazard model, we propose to estimate the induced relative risk function in the non-validation set through kernel smoothing method and then obtain an estimated pseudo-partial likelihood function. The proposed estimator which maximizes the estimated pseudo-partial likelihood is shown to be consistent and asymptotically normal. We also give an estimator of the marginal cumulative baseline hazard function. Simulation studies are conducted to evaluate the finite sample performance of our proposed estimator. The proposed method is illustrated by analyzing a heart disease data from the Study of Left Ventricular Dysfunction (SOLVD).     

左截断右删失数据下半参数模型风险率函数估计

文章给出了右删失左截断数据半参数模型下的风险率函数估计,讨论了风险率函数估计的渐近性质,获得了这些估计的渐近正态性,对数律和重对数律.由于假定删失机制服从半参数模型下,从而知道模型的更多信息,因此对于给出参数的极大似然估计,可以改进风险率函数估计的渐近性质.也就是说,删失数据模型具有半参数的辅助信息下, 风险率函数估计的渐近方差比通常的完全非参数的估计的渐近方差更小.这说明加入了额外的信息提高了风险率函数估计的效率.     

On estimation of survival function under random censoring model

We study an estimator of the survival function under the random censoring model. Bahadur-type representation of the estimator is obtained and asymptotic expression for its mean squared errors is given, which leads to the consistency and asymptotic normality of the estimator. A data-driven local bandwidth selection rule for the estimator is proposed. It is worth noting that the estimator is consistent at left boundary points, which contrasts with the cases of density and hazard rate estimation. A Monte Carlo comparison of different estimators is made and it appears that the proposed data-driven estimators have certain advantages over the common Kaplan-Meier estmator.     

Hazard Rate Regression Using Ordinary Nonparametric Regression Smoothers

Abstract

This article proposes a method for nonparametric estimation of hazard rates as a function of time and possibly multiple covariates. The method is based on dividing the time axis into intervals, and calculating number of event and follow-up time contributions from the different intervals. The number of event and follow-up time data are then separately smoothed on time and the covariates, and the hazard rate estimators obtained by taking the ratio. Pointwise consistency and asymptotic normality are shown for the hazard rate estimators for a certain class of smoothers, which includes some standard approaches to locally weighted regression and kernel regression. It is shown through simulation that a variance estimator based on this asymptotic distribution is reasonably reliable in practice. The problem of how to select the smoothing parameter is considered, but a satisfactory resolution to this problem has not been identified. The method is illustrated using data from several breast cancer clinical trials.     

Local asymptotic behavior of regression splines for marginal semiparametric models with longitudinal data

In this paper, we study the local asymptotic behavior of the regression spline estimator in the framework of marginal semiparametric model. Similarly to Zhu, Fung and He (2008), we give explicit expression for the asymptotic bias of regression spline estimator for nonparametric function f. Our results also show that the asymptotic bias of the regression spline estimator does not depend on the working covariance matrix, which distinguishes the regression splines from the smoothing splines and the seemingly u...     

Additive–multiplicative hazards model with current status data

The additive–multiplicative hazards (AMH) regression model specifies an additive and multiplicative form on the hazard function for the counting process associated with a multidimensional covariate process, which contains the Cox proportional hazards model and the additive hazards model as its special cases. In this paper, we study the AMH model with current status data, where the cumulative hazard hazard function is assumed to be nonparametric and is estimated using B-splines with monotonicity constraint on the functional, while a simultaneous sieve maximum likelihood estimation is proposed to estimate regression parameters. The proposed estimator for the parameter vector is shown to be asymptotically normal and semiparametric efficient. The B-splines estimator of the functional of the cumulative hazard function is shown to achieve the optimal nonparametric rate of convergence. A simulation study is conducted to examine the finite sample performance of the proposed estimators and algorithm, and a real data example is presented for illustration.     

Multivariate Hazard Rates under Random Censorship

The data consists of multivariate failure times under right random censorship. By the kernel smoothing technique, convolutions of cumulative multivariate hazard functions suggest estimators of the so-called multivariate hazard functions. We establish strong i.i.d. representations and uniform bounds of the remainder terms on some compact sets of the underlying space. Thus asymptotic normality and uniform consistency on such sets are obtained. The asymptotic mean squared error gives an optimal bandwidth by the plug-in method. Simulations assess the performance of our estimators.     

A Berry-Esséen Bound for the Product-Limit Estimator under Left-Truncation and Right-Censoring

For left-truncated and right-censored data, the product-limit estimator F?_xis a well-known nonparametric estimator for the distribution function F_x of the target variable X such as the survival time. Since F?_xas a very complicated product form we establish first the Berry-Esseen bound for the cumulative hazard estimator of F_x The cumulative hazard estimator can be represented as a U-statistic. By using the result in Helmers and van Zwet [6], we derive the Berry-esséen bound for this U-statistic. Then Berry-Esseen bounds for the distribution of the cumulative hazard estimator and the normal distribution and the distribution of the product-limit estimator and the normal distribution are obtained.     

STRONG REPRESENTATIONS OF THE SURVIVAL FUNCTION ESTIMATOR ON INCREASING SETS FOR TRUNCATED AND CENSORED DATA

1991MRSubjectClassification62G05,62E201IntroductionandtheMainResultsInthisarticlewestudysllrvivaldatawhicharesubjecttobothlefttrull(:ationandrightcensoring(LTRC).Morespecifically,let(X,T,Y)denoterandomvariableswhereXisthevariableofinterest,calledthelifetimevariable,withunknowndistributionfullctioll(d.f.)F;Tistherandomlefttruncatiolltiliiewitharbitraryd.f.G,andYistherandorl.1rightcensoringtirliewitharbitraryd.f.H.ItisassumedthatX,T,Yarerxlutuallyindependent.Intheran相似文献   

Smoothing estimation of rate function for recurrent event data with informative censoring

This paper proposes kernel estimation of the occurrence rate function for recurrent event data with informative censoring. An informative censoring model is considered with assumptions made on the joint distribution of the recurrent event process and the censoring time without modeling the censoring distribution. Under the validity of the informative censoring model, we also show that an estimator based on the assumption of independent censoring becomes inappropriate and is generally asymptotically biased. To investigate the asymptotic properties of the proposed estimator, the explicit form of its asymptotic mean squared risk and the asymptotic normality are derived. Meanwhile, the empirical consistent smoothing estimator for the variance function of the estimator is suggested. The performance of the estimators are also studied through Monte Carlo simulations. An epidemiological example of intravenous drug user data is used to show the influence of informative censoring in the estimation of the occurrence rate functions for inpatient cares over time.     

M-estimation in nonparametric regression under strong dependence and infinite variance

A robust local linear regression smoothing estimator for a nonparametric regression model with heavy-tailed dependent errors is considered in this paper. Under certain regularity conditions, the weak consistency and asymptotic distribution of the proposed estimators are obtained. If the errors are short-range dependent, then the limiting distribution of the estimator is normal. If the data are long-range dependent, then the limiting distribution of the estimator is a stable distribution.     

Marginal quantile regression for varying coefficient models with longitudinal data

In this paper, we investigate the quantile varying coefficient model for longitudinal data, where the unknown nonparametric functions are approximated by polynomial splines and the estimators are obtained by minimizing the quadratic inference function. The theoretical properties of the resulting estimators are established, and they achieve the optimal convergence rate for the nonparametric functions. Since the objective function is non-smooth, an estimation procedure is proposed that uses induced smoothing and we prove that the smoothed estimator is asymptotically equivalent to the original estimator. Moreover, we propose a variable selection procedure based on the regularization method, which can simultaneously estimate and select important nonparametric components and has the asymptotic oracle property. Extensive simulations and a real data analysis show the usefulness of the proposed method.

     

Density and hazard rate estimation for censored data via strong representation of the Kaplan-Meier estimator

Summary We study the estimation of a density and a hazard rate function based on censored data by the kernel smoothing method. Our technique is facilitated by a recent result of Lo and Singh (1986) which establishes a strong uniform approximation of the Kaplan-Meier estimator by an average of independent random variables. (Note that the approximation is carried out on the original probability space, which should be distinguished from the Hungarian embedding approach.) Pointwise strong consistency and a law of iterated logarithm are derived, as well as the mean squared error expression and asymptotic normality, which is obtain using a more traditional method, as compared with the Hajek projection employed by Tanner and Wong (1983).     

Estimation and Bootstrap with Censored Data in Fixed Design Nonparametric Regression

We study Beran's extension of the Kaplan-Meier estimator for thesituation of right censored observations at fixed covariate values. Thisestimator for the conditional distribution function at a given value of thecovariate involves smoothing with Gasser-Müller weights. We establishan almost sure asymptotic representation which provides a key tool forobtaining central limit results. To avoid complicated estimation ofasymptotic bias and variance parameters, we propose a resampling methodwhich takes the covariate information into account. An asymptoticrepresentation for the bootstrapped estimator is proved and the strongconsistency of the bootstrap approximation to the conditional distributionfunction is obtained.     

Estimation and confidence bands of a conditional survival function with censoring indicators missing at random

The nonparametric estimator of the conditional survival function proposed by Beran is a useful tool to evaluate the effects of covariates in the presence of random right censoring. However, censoring indicators of right censored data may be missing for different reasons in many applications. We propose some estimators of the conditional cumulative hazard and survival functions which allow to handle this situation. We also construct the likelihood ratio confidence bands for them and obtain their asymptotic properties. Simulation studies are used to evaluate the performances of the estimators and their confidence bands.     

An embedded estimating equation for the additive risk model with biased-sampling data

This paper presents a novel class of semiparametric estimating functions for the additive model with right-censored data that are obtained from general biased-sampling. The new estimator can be obtained using a weighted estimating equation for the covariate coeffcients, by embedding the biased-sampling data into left-truncated and right-censored data. The asymptotic properties (consistency and asymptotic normality) of the proposed estimator are derived via the modern empirical processes theory. Based on the cumulative residual processes, we also propose graphical and numerical methods to assess the adequacy of the additive risk model. The good finite-sample performance of the proposed estimator is demonstrated by simulation studies and two applications of real datasets.     

Estimating a survival function with doubly censored data in a proportional hazard model

This article presents a non-parametric estimator of a survival function in a proportional hazard model when some of the data are censored on the left and some are censored on the right. The proposed method generalizes the work of Ebrahimi (1985). Uniformly strong consistency and asymptotic normality of the estimator are proved. A computer simulation study is presented to analyse the behaviour of the estimator when model assumptions fit the data and when they do not fit.     

Smooth estimation of survival and density functions for a stationary associated process using Poisson weights

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Asymptotic bounds for the expected L error of a multivariate kernel density estimator

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Composing the cumulative quantile regression function and the Goldie concentration curve

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