A series of twelve new 2‐[(o‐ and p‐substituted)aminophenyl]‐3H‐5‐[(o‐ and p‐substituted)phenyl]‐7‐chloro‐1,4‐benzodiazepines, which have possible pharmacological properties has been obtained. The synthesis was carried out following six steps. The structure of all products was corroborated by ir, 1H nmr, 13C nmr and ms. In addition for the compound 2‐(o‐chloroaminophenyl)‐3H‐5‐(o‐fluorophenyl)‐7‐chloro‐1,4‐benzodiazepine 7, its structure was confirmed by X‐ray diffraction. 相似文献
The rod‐like molecule of the title hydrocarbon, C24H18, is centrosymmetric, with the centroid of the central benzene ring residing on an inversion center. The molecules display a planar conformation of the benzene rings and aggregate into stacks along the [010] direction via Csp3—H⋯π(arene) interactions, thus forming a stair‐like pseudo‐two‐dimensional network. Each molecule acts as both a C—H hydrogen donor and a π‐arene acceptor, forming four hydrogen bonds per molecule. 相似文献
A second polymorphic form (form II) of the previously reported 1,4,7‐tris(p‐tolylsulfonyl)‐1,4,7‐triazacyclononane (form I), C27H33N3O6S3, is presented. The molecular structures of the two forms display very different conformations, thus prompting the two forms to crystallize in two different space groups and exhibit quite diverse crystal structure assemblies. Form I crystallizes in the triclinic space group P, while form II crystallizes in the monoclinic space group P21/n. The main differences between the two molecular structures are the conformations of the p‐tosyl groups relative to each other and to the macrocyclic ring. The resulting crystal packing displays no classical hydrogen bonds, but different supramolecular synthons give rise to different packing motifs. 相似文献
A series of eleven new 2‐methylthio‐3H‐7‐[(o‐; m‐ and p‐substituted) phenoxy]‐4‐(p‐substituted‐phenyl)‐[1,5]benzodiazepines, which have potentially useful pharmacological activities, has been synthesized by condensing the 4‐[(o‐; m‐ and p‐R1)phenoxy]‐1,2‐phenylendiamines with 3,3‐dimercapto‐1‐(p‐R2‐phenyl)‐2‐propen‐1‐one. Afterward the lH‐[1,5]benzodiazepine‐2‐thiones obtained were treated with sodium hydride and methyl iodide. The structure of all products was corroborated by ir, 1H nmr, 13C nmr and ms. 相似文献
A novel PVC‐based membrane sensor based on 2,6‐(p‐N,N‐dimethylaminophenyl)‐4‐phenylthiopyrylium perchlorate (DAPP) is described. The electrode exhibits a sub‐Nernstian response to 1‐(beta‐hydroxyethyl)‐2‐methyl‐5‐nitroimidazole (metronidazol) over a relatively wide concentration range (1.0 × 10?1 to 1.0 × 10?5 M) with a detection limit of 8.0 × 10?6 M. The best performance was obtained with the membrane containing 30% poly (vinyl chloride), 50% dibutyl phthalate, 7% DAPP and 13% oleic acid. It has a fast response time (< 30 s) and can be used for at least four weeks without any major deviation. The proposed sensor revealed very good selectivity for metronidazole over a wide variety of common cations, anions and amino acids and could be used in the pH range of 6.0–7.5. It was successfully used for direct determination of metronidazole in an oral synthetic antiprotozoal as an antibacterial agent, in metronidazole tablets, and metronidazole injections and metronidazole gels. 相似文献
MoOCl2(LOMe) as catalyst, where LOMe is CpCo[P(O)(OMe)2]3, reacts with p‐tolyl isocyanate to afford the title compound, C23H23N3O2. The structural features are the intramolecular hydrogen bond forming a six‐membered ring and a nearly planar arrangement of the biuret moiety. Each p‐tolyl phenyl ring is twisted by approximately 60–80° with respect to the others. The bond lengths N1—C22 of 1.357 (3) Å and N2—C23 of 1.333 (3) Å indicate that they are partial double bonds. 相似文献
Summary: The vapor‐based synthesis and characterization of a reactive polymer, poly[(4‐formyl‐p‐xylylene)‐co‐(p‐xylylene)] ( 1 ), have been reported. The reactive polymer coating enables the immobilization of oligosaccharides via the chemoselective aldehyde‐hydrazide coupling reaction.