共查询到20条相似文献,搜索用时 122 毫秒
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含氟化合物表现出的特殊理化和生物活性使得其在药物、农用化学品和材料科学等领域有着广泛而重要的应用,因此,含氟化合物的高效制备不仅成为了合成化学的研究热点之一,而且极大地推动了相关领域的蓬勃发展.其中,在有机分子内直接引入氟原子的方法主要有亲电氟化和亲核氟化.相较于亲电氟化,亲核氟化反应所用的氟化试剂通常廉价易得,所需的反应条件也比较温和.作者课题组借助过渡金属催化、可见光氧化还原催化和可见光促进策略,拓展了亲核性氟源在碳碳不饱和键选择性氟化官能化反应中的应用,合成了一系列结构新颖的含氟化合物.在该研究评论中将对此做出小结,并对该领域值得关注的研究方向进行简要的展望. 相似文献
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过渡金属化学已发展成为有机合成的重要方法,本文综述了它在精细有机合成中应用的一些进展。叙述了金属有机化合物作为亲电体与亲核试剂反应,金属有机化合物作为亲核体与亲电试剂反应,以及偶合和环化反应。应用这些反应可以巧妙地合成若干天然产物。 相似文献
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三甲基硅化腈是一种常用的有机合成试剂. 对近年来三甲基硅化腈在有机合成中的应用进行了简要的总结和概述, 重点介绍了三甲基硅化腈作为强的亲核试剂广泛用于环氮和环氧化合物的开环反应、亚胺和醛酮类化合物的加成、胺与醛或酮参与的多组分反应、偶联反应以及对炔和具有较高活性的碳碳双键的氰化加成等反应. 相似文献
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离子液体作为一类新型绿色溶剂,具有制备简单、稳定性好、溶解能力强、挥发性小、安全性强等优点,因此在有机单元反应包括酯化、氧化、还原、重排反应等中的应用相当广泛,有着十分诱人的应用前景.虽然其在氟化反应中的应用研究开始得较晚,但发展很快,目前在重氮化氟化、亲核氟化、亲电氟化以及电化学氟化等方面都取得了较大的进展.本文综述了近年来离子液体在氟化反应中应用的最新进展情况,并对其未来发展方向和应用前景进行了展望. 相似文献
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The action of tosyl chloride on bisfluorohydrins gives the corresponding tosylates which are converted into bis(vicinal difluorinated) polyoxyethylene glycols by reaction with potassium fluoride and triethylamine tris(hydrofluoride) mixture. 相似文献
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The microwave-assisted synthesis of terminal α-hydroxy ketones from acid chlorides and tris(trimethylsiloxy)ethylene in the presence of triethylamine is reported. The use of triethylamine had several advantages in the reaction: it increased the reactivity of the acid chloride, acted as a scavenger of the HCl that was produced in the reaction, protected the silylated enol from decomposition, and made the excess use of the silyl reagent unnecessary. Mechanistic effects of triethylamine are discussed. Effects of various base additives, reaction temperatures, reaction times, and solvents in the reaction are compared. 相似文献
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N. K. Gusarova S. F. Malysheva N. A. Belogorlova S. I. Verkhoturova L. A. Oparina S. N. Arbuzova N. A. Chernysheva A. M. Nalibayeva G. K. Bishimbayeva S. V. Yasko B. A. Trofimov 《Russian Journal of General Chemistry》2020,90(5):839-844
Two ways for the synthesis of new representatives of non-symmetric organic
phosphites with polyfluoroalkyl substituents were developed based on organic
dichlorophosphites. The reaction of polyfluoroalkyl dichlorophosphites with
allyl alcohol, proceeding at a temperature of –10–22°C (2 h) in the presence of
triethylamine, gave diallyl polyfluoroalkyl phosphites in a yield of 75–77%.
Under similar conditions (–30–22°C, 2–4 h, Et3N), alkyl
(or aryl) dichlorophosphites reacted with polyfluoroalkanols to form alkyl (or
aryl) bis(polyfluoroalkyl) phosphites (yield 56–67%). Unlike
diallylpolyfluoroalkyl- and alkylbis(polyfluoroalkyl) phosphites,
arylbis(polyfluoroalkyl) phosphites are symmetrized under storage conditions
(room temperature, inert atmosphere), forming the corresponding triaryl- and
tris(polyfluoroalkyl) phosphites. 相似文献
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Preparation and Properties of Some Methoxylated Oligosilanes Tetrakis(trichlorsilyl)silane reacts with methanol and triethylamine to tetrakis(trimethoxysilyl)silane ( I ) or a mixture of I , tris(trimethoxysilyl)silane ( II ), Bis(trimethoxysilyl)silane ( III ) and tetramethoxysilane, depending on the reaction conditions. II is chlorinated to tris(trimethoxysilyl)chlorosilane ( IV ) by CCl4, IV can be further methoxylated to tris(trimethoxysilyl)methoxysilane ( V ). The compounds I–V are characterized by vibrational, 1H-nmr-, u.v.- as well as mass spectra. 相似文献
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The Mitsunobu reaction is a well-established fundamental reaction and has been widely applied in organic synthesis. In this
paper, under Mitsunobu conditions dehydration proceeds between (2-chloroquinolin-3-yl)methanol and nitrogen heterocyclic compounds
such as quinazolinone, pyrimidone, 2-oxoquinoline in dry THF in the presence of triethylamine, triphenylphosphane and diethyl
azodicarboxylate to give the corresponding products. As part of our recent research, we attempted to couple two N-heterocyclic compounds under Mitsunobu reaction conditions to provide efficient building blocks for natural product synthesis. 相似文献
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Enthalpies of reaction for proton transfer in methanol-water mixtures are related to the enthalpies of mixing of methanol and water. The data are direct calorimetric measurements of the standard enthalpies of proton transfer in methanol-water mixtures of varying composition using the bases quinuclidine triethylamine, and tris(hydroxymethyl)aminomethane. Other possible applications of the principle are mentioned.decreased 相似文献
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Lei Li Guangyuan Wang Shanshan Wei Xilong Yan Ligong Chen 《Research on Chemical Intermediates》2013,39(2):615-620
A modified procedure for synthesis of the side chain of ceftazidime-activated thioester has been established. This key intermediate of ceftazidime was obtained by a more eco-friendly process than conventional methods, and the yield was much higher (up to 92.4 %). It was found that different organic bases (triethylamine or pyridine) used in this reaction had different effects. The reaction conditions were also optimized to make the route more competitive and suitable for large-scale industrial production. 相似文献
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聂国朝 《影像科学与光化学》2004,22(4):293-297
将微波辐射与相转移催化技术相结合,在加压密闭容器中,以氨水和丙烯腈合成了配位中间体三(2-氰乙基)胺,产率为61.2%,合成时间比传统方法缩短了8倍;在微波辐射下,产率为67.2%,合成时间缩短约90倍.对产物进行了元素分析,IR,1H-NMR,ES-MS,及TG-DTA表征. 相似文献
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[reaction: see text] Dendrimers containing an encapsulated tertiary amine were prepared by coupling tris(2-aminoethyl)amine with dendritic branches derived from L-lysine. These dendrimers were used as catalysts in the Henry (nitroaldol) reaction between 4-nitrobenzaldehyde and nitroethane, and their catalytic performance was compared with that of triethylamine. Attachment of the dendritic shell alters the rate of reaction and influences the syn:anti ratio of products. It is proposed that the dendritic shell generates an encapsulated catalytically active site, mimicking the behavior of a protein superstructure. 相似文献
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WANG Hua ZHAO Mi-feng PU Li-mei DING Wei HUANG Yi-bing HOU Rui-zhen ZENG Hong-bin XU Li ZHANG Xue-zhong 《高等学校化学研究》2006,22(6):721-726
IntroductionA characteristic tripeptide sequence Arg-Gly-Asp(RGD) that is found within fibronectin and other rela-ted adhesion molecules in extracellular matrices(ECM)has received considerable attention from researcherssince it was proved to be a recognit… 相似文献