共查询到20条相似文献,搜索用时 937 毫秒
1.
哒嗪—3—酮类化合物的合成进展 总被引:1,自引:0,他引:1
综述了近年来哒嗪酮环骨架合成方法的研究进展,包括:1)由二羰基化合物合成;2)采用环加成反应;3)杂环转化法,以及其它方法,还叙述了哒嗪酮核苷的合成,参考文献22篇。 相似文献
2.
众所周知,许多嘧啶的核苷类化合物都有较强的生理活性,其中5-氟脲苷是有效的抗癌药。而哒嗪和嘧啶在结构上具有同分异构关系,因此,对于哒嗪核苷类化合物的合成及其生 相似文献
3.
碳环核苷是呋喃糖环部分被碳环基团取代的核苷类似物.作为天然核苷的类似物,许多碳环核苷具有良好的抗病毒、抗肿瘤活性.同时,由于不存在典型的糖苷键,碳环核苷较天然核苷对于磷酸化酶和水解酶具有更高的代谢稳定性.因此,对碳环核苷类似物进行设计与合成,并筛选出安全有效的抗病毒试剂成为近年来药物化学家们研究的重点.按照碱基种类的不同综述了近5年来碳环核苷的合成研究进展,分为嘌呤类碳环核苷、嘧啶类碳环核苷以及碳环C-核苷等三部分,重点介绍了嘌呤类碳环核苷的合成研究,并对碳环核苷未来的研究趋势进行了展望. 相似文献
4.
5.
6.
氟代哒嗪类化合物与有一定生理活性的氟代嘧啶类化合物有着同分异构的关系。而4-氟-3,6-二氯哒嗪又是合成其它药物的重要中间体。1984年田官荣报道了4-氟-3,6-二氯哒嗪的合成及同亲核试剂的反应性能和同类化合物 相似文献
7.
9.
10.
11.
Russian Journal of General Chemistry - Alkyl E-3-(furyl)-3-(diethoxyphosphoryl)acrylates containing a mercaptomethyl group in the position of the furan ring adjacent to the alkene moiety are easily... 相似文献
12.
A simple route to 1-R-3-(2-indolyl)-1-propanones has been elaborated based on recyclization of 2-(2-aminobenzyl)furan derivatives. Being a modification of the Reissert indole synthesis, our approach employs the furan ring as a source of carbonyl function. This approach is general and allows varying of substituents in aromatic ring as well as in 3-position of indole nucleus. 相似文献
13.
It was established that substituents primarily are incorporated in the benzene ring in the bromination and nitration of 2(3)-phenyl-5(6)-hydroxybenzofurans. The acetoxy derivatives of the same benzofurans are brominated and nitrated only in the free position of the furan ring.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 3, pp. 311–315, March, 1976. 相似文献
14.
7-Chloro-3-(β- D -2,3,5-tri-O-benzoylribofuranosyl)imidazo[4,5-c] pyridazine ( 3 ), obtained from the condensation of 7-chloro-3-trimethylsilylimidazo[4,5-c] pyridazine ( 1 ) with 2,3,5-tri-O-benzoyl- D -ribofuranosyl bromide ( 2 ), served as the percursor of 7-chloro- ( 4 ), 7-amino- ( 8 ), and 7-mercapto-3-(β- D -ribofuranosyl)imidazo[4,5-c] pyridazine ( 9 ). 3-(β- D -ribofuranosyl)imidazo[4,5-c] pyridazine ( 7 ) was obtained from 3-(β- D -2,3,5-tri-O-benzoylribofuranosyl)imidazo-[4,5-c]pyridazine ( 6 ). The site of ribosidation is based upon uv spectral comparisons with model methyl compounds. The assignment of the anomeric configuration is derived from pmr spectral data. 相似文献
15.
L. M. Pevzner 《Russian Journal of General Chemistry》2016,86(1):62-67
Preparative procedure for 4,5-bis(diethoxyphosphorylmethyl)-3-furoate from 4-chloromethyl-3-furoate is developed. It includes substitution of chlorine with iodine, phosphorylation by means of the Arbuzov reaction, chloromethylation of 4-(diethoxyphosphorylmethyl)-3-furoate in the position 5 of the furan ring, substitution of chlorine with iodine in the obtained chloromethyl derivative, and repeated phosphorylation with triethyl phosphite. It was found that ethyl 4-(diethoxyphosphorylmethyl)-5(chloromethyl)-3-furoate reacts with sodium diethyl phosphite by two pathways. Besides usual nucleophilic substitution leading to phosphonate, transfer of the reaction center in the position 2 of the furan ring takes place. The ambident diethylphosphite anion in this case reacts at the oxygen to give tertiary phosphite. The latter is oxidized with the air oxygen to form ethyl 2-(diethoxyphosphoryloxy)-4-(diethoxyphosphorylmethyl)-5-methyl-3-furoate. Unlike that analogous iodomethyl phosphonate is phosphorylated selectively under the conditions of the Arbuzov reaction. 相似文献
16.
Axundova F. N. Kurbanova M. M. Huseynzada A. E. Alves M. J. 《Russian Journal of Organic Chemistry》2019,55(12):1975-1978
(S)-(1,2,3,6-Tetrahydropyridazin-3-yl)methanol was synthesized in two steps by the Diels-Alder reaction of penta-2,4-dien-1-ol with diethyl azodicarboxylate in the presence of (S)-BINOL as chiral catalyst. The subsequent Boc-protection of the 2-position of the pyridazine ring, ring-closing carbonylation of the hydroxy group, and deprotection afforded a bicyclic iminosugar analog. The structure of the isolated compounds was proved by NMR, IR, and mass spectra and elemental analyses.
相似文献17.
Dimethyl(methylene)ammonium chloride reacts with 2-, 3-(diethoxyphosphorylmethyl)furansby the free position of the furan ring to give the corresponding aminomethyl derivatives. 2,5-Disubstitutedfurans do not enter this reaction. 相似文献
18.
E. V. Vlasova A. A. Aleksandrov M. M. Elchaninov A. A. Milov B. S. Lukyanov 《Chemistry of Heterocyclic Compounds》2011,47(6):684-689
5-(2-Furyl)-1-methyl-1H- and 1-methyl-5-(2-thienyl)-1H-imidazoles were synthesized. The electronwithdrawing effect of the
5- and 2-imidazole substituents on the furan ring was studied by 1H NMR spectroscopy and quantum-chemical calculations. Some electrophilic substitution reactions were investigated (nitration,
bromination, sulfonation, hydroxymethylation, formylation, and acylation). In some cases, depending on the reaction conditions,
both the furan and thiophene ring and the imidazole fragment undergo electrophilic attack. 相似文献
19.
L. M. Pevzner 《Russian Journal of General Chemistry》2017,87(6):1148-1160
By an example of butanethiol the addition of mercaptanes in the presence of bases to alkyl 3-furyl-3-(diethoxyphosphoryl)acrylic acids having methyl, methoxymethyl, or diethoxyphosphorylmethyl substituent in the furan ring was studied. It was shown that in the majority of cases alkyl 2-(butylthio)propionate was the main product, and 3-(butylthio)propionate was the minor one. Ethyl 3-(4-methylfur-3-yl)-3-(diethoxyphosphoryl) acrylate affords these two substances in equal quantities. In the case of ethyl 3-(4-methoxymethyl-5-methylfur-2-yl)-3-(diethoxyphosphoryl)acrylate only 3-(butylthio)propionate is formed. 相似文献
20.
《Journal of heterocyclic chemistry》2017,54(1):670-676
Using 3‐(4‐cyano phenoxy)‐6‐methyl‐4‐(3‐trifluoromethylphenyl) pyridazine (compound A ) as a leading compound, a total of 24 novel 3‐(substituted phenoxy)‐6‐methyl‐4‐(3‐trifluoromethylphenyl) pyridazine derivatives containing two electron‐withdrawing groups on the benzene ring (acylamine and oxime ether) were synthesized. Their herbicidal, insecticidal activities were bioassayed, and the herbicidal activity of compound CD-2 against Brassica campestris was 97.6% at 300 g/ha, which was better than the commercial herbicide diflufenican at the this concentration and is equal to the activity of the leading compound A . Compound CD-4 , CD-5 , CJ-3 , and CJ-5 displayed excellent insecticidal activity against Aphis laburni Kaltenbach (>95%). The results show that the oxime ether substitutions exhibit better bleaching and herbicidal activity than the acylamine ones. The bleaching and herbicidal activity of para‐position substitutions is better than the meta‐position ones. It seems that the para‐position on the benzene ring of oxime ether pyridazine derivatives is one of the key active sites that affect their herbicidal activities. 相似文献