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Harsha E. Rajapakse D. Rajasekhar Reddy Dr. Shabnam Mohandessi Nathaniel G. Butlin Dr. Lawrence W. Miller Prof. Dr. 《Angewandte Chemie (International ed. in English)》2009,48(27):4990-4992
Brilliance of terbium : Heterodimeric conjugates of trimethoprim covalently linked to sensitized terbium chelates bind to Escherichia coli dihydrofolate reductase fusion proteins with nanomolar affinity (see picture). Terbium luminescence enables sensitive and time‐resolved detection of labeled proteins in vitro and on the surface of living mammalian cells.
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Symmetry versus Minimal Pentagonal Adjacencies in Uranium‐Based Polyoxometalate Fullerene Topologies
Ginger E. Sigmon Daniel K. Unruh Jie Ling Brittany Weaver Matthew Ward Laura Pressprich Antonio Simonetti Prof. Peter C. Burns Prof. 《Angewandte Chemie (International ed. in English)》2009,48(15):2737-2740
C U soon : Clusters containing 60, 44, and 36 uranyl peroxide hydroxide polyhedra (see picture) adopt fullerene topologies of maximum symmetry. The largest of these, denoted U60, is topologically identical to C60 with no pentagonal adjacencies and the highest possible symmetry. U44 adopts the topology with maximum symmetry rather than that with the lowest number of pentagonal adjacencies.
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Lars K. Ottesen Christian A. Olsen Dr. Matthias Witt Dr. Jerzy W. Jaroszewski Prof. Henrik Franzyk Prof. 《Chemistry (Weinheim an der Bergstrasse, Germany)》2009,15(12):2966-2978
Robust protocol! A diverse array of piperazine scaffolds was obtained by a robust solid‐phase‐synthesis protocol involving multistep elaboration of a resin‐bound aziridine (see scheme). Microwave‐assisted on‐resin protectinggroup introduction and manipulation as well as intramolecular Fukuyama–Mitsunobu cyclization conditions were key features.
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Peng Wu Ella Lai‐Ming Wong Dr. Dik‐Lung Ma Dr. Glenna So‐Ming Tong Dr. Kwan‐Ming Ng Dr. Chi‐Ming Che Prof. Dr. 《Chemistry (Weinheim an der Bergstrasse, Germany)》2009,15(15):3623-3623
Photoluminescent cyclometalated platinum(II) complexes can bind non‐covalently and non‐specifically towards various proteins and such bonding is accompanied by a dramatic increase in the intensity of photoluminescence in the visible spectral region. It can be practically applied for staining protein mixtures in 1D and 2D SDS‐PAGE, giving emissive gel images directly under UV light without any de‐staining procedures. For more information see the Communication by C.‐M. Che et al. on page 3652 ff. (SDS‐PAGE=sodium dodecyl sulfate polyarcylamide gel electrophoresis).
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Jörn Schmedt auf der Günne Dr. 《Angewandte Chemie (International ed. in English)》2009,48(19):3401-3403
On an atomic scale and with high sensitivity, solid‐state NMR spectroscopy can provide information about the electronic spin density and coupling mechanisms in paramagnetic compounds. The picture shows how the hyperfine splitting collapses through relaxation. Insights into which compounds are suitable and which approximations have to be made are given.
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Miguel Ruiz‐Osés Dimas G. de Oteyza Dr. Isabel Fernández‐Torrente Nora Gonzalez‐Lakunza Phillipp M. Schmidt‐Weber Dr. Thorsten Kampen Dr. Karsten Horn Prof. André Gourdon Prof. Andrés Arnau Prof. J. Enrique Ortega Prof. 《Chemphyschem》2009,10(6):896-900
A new view: A picture of the different non‐covalent interactions relevant for the self‐assembly of organic layers and their spectroscopic fingerprints is provided (see figure). In particular, state‐of‐the‐art spectroscopic measurements are performed for supramolecular assemblies, comparing the electronic structure of single‐component layers with that of binary organic layers.
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Toshihide Maki Dr. Shinya Iikawa Gen Mogami Hitomi Harasawa Yoshihiro Matsumura Prof. Dr. Osamu Onomura Prof. Dr. 《Chemistry (Weinheim an der Bergstrasse, Germany)》2009,15(21):5364-5370
Get selective! A selective oxidation of 1,2‐diols to α‐hydroxyketones catalyzed by organotin compounds has been developed (see scheme). Invaluable chemo‐ and stereoselectivity were found in the reaction. The catalytic system has been achieved by electrochemical and chemical oxidation.
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Jan Gebers Damien Rolland Holger Frauenrath Prof. 《Angewandte Chemie (International ed. in English)》2009,48(25):4480-4483
A limited number of poly(ethylene oxide)‐substituted perylene bisimides, some of which are equipped with terpyridine ligands for transition‐metal coordination (see structure), combine different types of noncovalent interactions to yield optoelectronically active organic materials with different types of supramolecular morphologies.
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Fengtao Fan Keju Sun Zhaochi Feng Dr. Haian Xia Bo Han Yuxiang Lian Pinliang Ying Dr. Can Li Prof. Dr. 《Chemistry (Weinheim an der Bergstrasse, Germany)》2009,15(13):3268-3276
The nucleation process of iron‐exchanged zeolite Fe‐ZSM‐5, from the assembly of distorted tetrahedrally coordinated iron species and silicate rings in the precursor to the final Fe‐ZSM‐5 crystals, as well as variations in the coordination environment of iron, were studied by UV resonance Raman spectroscopy and complementary techniques.
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Laurent A. Baumes Dr. Manuel Moliner Dr. Avelino Corma Dr. 《Chemistry (Weinheim an der Bergstrasse, Germany)》2009,15(17):4258-4269
Finding a clear route to new structures : The design of an adaptable time warping (ATW) methodology (see figure) for automatically, quickly, and reliably deciphering X‐ray diffraction patterns is described.
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Maximilian Dochnahl Dr. Gregory C. Fu Prof. Dr. 《Angewandte Chemie (International ed. in English)》2009,48(13):2391-2393
The appropriate choice of chiral catalyst and starting materials leads to the synthesis of 1,2‐oxazetidin‐3‐ones by cycloadditions of ketenes with nitroso compounds with very good regioselectivity and enantioselectivity. In addition to serving as potentially bioactive target molecules, the products can be transformed into other important classes of compounds, such as α‐hydroxycarboxylic acid derivatives.