Synthesis of melamine-glucose resin adhesive

The synthesis of a novel melamine-glucose adhesive that is similar to urea-formaldehyde adhesive is reported in this paper. The conditions of synthesis, such as the initial pH, the quantity of catalyst, the temperature of reaction, the percentage of each reactant and the time of reaction, were optimized by using the orthogonal experimental method.     

Intrinsic Kinetics of Dimethyl Ether Synthesis from Syngas

The intrinsic kinetics of dimethyl ether (DME) synthesis from syngas over a methanol synthesis catalyst mixed with methanol dehydration catalyst has been investigated in a tubular integral reactor at 3-7MPa and 220-260℃. The three reactions including methanol synthesis from CO and H2, CO2 and H2, and methanol dehydration were chosen as the independent reactions. The L-H kinetic model was presented for dimethyl ether synthesis and the parameters of the model were obtained by using simplex method combined with genetic algorithm. The model is reliable according to statistical analysis and residual error analysis. The synergy effect of the reactions over the bifunctional catalyst was compared with the effect for methanol synthesis catalyst under the same conditions based on the model. The effects of syngas containing N2 on the reactions were also simulated.     

A Facile Synthesis of Ethyl 2,4-Dimethoxy-6-perfluoroalkyl-benzoates via Acyclic Precursors

Introduction Polysubstituted arenes are important intermediates in synthetic medicines and dyestuffs, and the fluorinated analogues are more attractive as a result of their lipo-philicity and the increment of activity.1,2 Therefore, to study the convenient and efficient synthesis of polysub-stituted arenes is valuable in organic synthetic method-ology. We have designed a simple synthesis of fluori-nated polysubstituted arenes through the intramolecular Wittig reaction of a new phosphorous ylid…     

Synthesis of Diethyl Oxalate by a Coupling-Regeneration Reaction of Carbon Monoxide

This article describes a process for the synthesis of diethyl oxalate by a coupling reaction of carbon monoxide, catalyzed by palladium in the presence of ethyl nitrite. The kinetics and mechanism of the coupling and regeneration reaction are also discussed. This paper presents the results of a scale-up test of the catalyst and the process based on an a priori computer simulation.     

Stereoselective Synthesis of (±) Neocnidilide

The lactone neocnidilide 8 occur in the roots of Cnidilide officinale1 which is shown to inhibit the growth and toxin production of mycotoxin-producing fungi2. Although The synthesis of lactones 7, which is stereoisomer of cnidilide, and 8 had been reported by others3, 4, we would like to report the highly stereoselective synthesis of its racemic isomer 8 as shown in Scheme 1. Scheme 1 COOHHOOCbcOOHH1234d5eOHOHHH 6fOOHHH 7g8COOHOHa12345673a7aOHHOH1235673 a7a1234561'1'2'…     

Synthesis of Diethyl Oxalate by a Coupling—Regeneration Reaction of Carbon Monoxide

This article describes a process for the synthesis of diethyl oxalate by a copling reaction of carbon monoxide,catalyzed by palladium in the presence of ethyl nitrite ,The kinetics and mechanism of the coupling and regeneration reaction are also discussed ,This paper presents the results of a scale-up test of the catalyst and the process based on an a priori computer simulation.     

Stereoselective Synthesis of C-Glycosides by Suzuki Cross-coupling Reaction

Carbohydrates and their conjugates have been recognized to play a wide variety of metabolic roles in numerous biological processes.[1] Various modified sugars and analogues have been recently synthesized for further investigation of glycosidase reactions and for the development of specific glycosidase inhibitors.[2] As one of the most important carbohydrate mimics, C-glycosides have attracted great attention due to their stability to chemical or enzymatic hydrolysis of the glycosidic linkage. A number of methodologies for the preparation of C-glycosides have been extensively investigated.[3] We have recently reported the syntheses of novel C-glycosyl amino acids and amino-C-disaccharides possessing a ketose form via the stereoselective 1,3-dipolar cycloaddition of exo-methylenesugars (1) and nitrones.[4,5] As a continuation of our research on the synthesis of C-glycosides using exo-methylenesugar as the precursor, we wish to describe here a stereoselective synthesis of C-glycosides by Suzuki cross-coupling reaction.     

Asymmetric Total Synthesis of a Diastereisomer A of Tuxpanolide

α-Alkylidene-β-hydroxy butyrolactones have been attractive and challenging targets for organic synthesis in various laboratories because that not only they are rich in skeletal diversity and stereochemistry complexity but also many of them possess quite intriguing and wide biological activities.[1] A novel class of the phytane-type diterpenoid named Tuxpanolide, bearing α-alkylidene-β-hydroxy-γ-butyrolactone skeleton, was isolated from Perymenium hintonii in Central Mexico by Maldonado and co-wokers in 1998.[2] Now we firstly report the efficient strategy of the stereocontrolled total synthesis of a diastereisomer A of Tuxpanolide.     

Novel Synthesis of Benzotriazol-1-yl Methyl Selenides and Tellurides

Benzotriazole has played an important role as a synthetic auxiliary for preparative chemists1. It is also well known that organic selenides or tellurides are versatile intermediates in organic synthesis2. However, there are only few reports on the synthesis of the difunctionalized compounds containing both benzotriazolyl group and organoselenium or tellurium group3. Herein we wish to report a new and convenient synthesis of benzotriazol-1-yl methyl selenides and tellurides 4a-h.Selenium or tel…     

Synthesis of a new series of anti-rhinovirus compounds

The synthesis of a series of 3,6-dichloropyridazine derivatives was described.In vitro experiment,all compounds exhibited ananti-rhinovirus activity,and one of the compounds 6g showed the comparable activity as our lead compound pirodavir.     

酰基膦酸酯的合成及其在有机合成中的应用研究进展

酰基膦酸酯是一类活泼的有机合成中间体。本文归纳介绍了此类化合物的合成方法以及其近年来在有机合成中的应用。     

Synthesis of kaempferitrin

A short synthesis of Kaempferitrin (1), a 3,7-diglycosylflavone, is reported. Key features include the synthesis of a protected form of kaempferol in which all four hydroxy groups are differentiated and the first bis-glycosylation of a dihydroxyflavone. This synthesis will allow the preparation of derivatives for further explorations into the origins of this compound's biological activity.     

绿色合成：一个逐步形成的学科前沿

绿色合成是有机合成化学面向新世纪的学科前沿。本文探讨绿色合成的目标及实现这一目标的一些可能途径。     

Synthesis of santiagonamine

The first total synthesis of santiagonamine (1) is achieved in 12 steps from isovanillin. A palladium-catalyzed Ullmann cross-coupling reaction and a photocyclization are the key steps in the synthesis.     

Advances in Microwave-Assisted Synthesis for Five-Membered N-Heterocycle Synthesis

The development of new strategies for the synthesis of small-sized heterocycles hasremained a highly attractive but challenging proposition. An overview of the application of microwave irradiation in the synthesis of nitrogen-containing five-membered heterocyclic compounds is presented, focusing on the developments in the past 5–10 years. This contribution covers the literature concerning the total synthesis of N-heterocycles.     

Synthesis of axinohydantoins

A short synthesis of the hydantoin-containing marine sponge metabolites axinohydantoins is described. A key feature of the synthesis is a putative biomimetic, intramolecular cyclization of alpha-functionalized imidazolone 5, which affords the tricyclic pyrroloazepinone framework comprising 6. In addition, the conversion of imidazolones to alpha,beta-unsaturated hydantoins is outlined and represents a new approach to these heterocyclic systems.     

Synthesis of maradolipid

The first synthesis of maradolipid, a unique dissymmetrically 6,6'-di-O-acylated trehalose glycolipid isolated from C. elegans, is accomplished in five steps starting from trehalose in 45% overall yield. The short synthesis relies on dissymmetrization of trehalose core via regioselective acylation of a 2,3,4,2',3',4'-hexa-O-TMS trehalose 6,6'-diol derivative as a key step.     

Total Synthesis of Mallotusinin

The total synthesis of mallotusinin, which bears a tetrahydroxydibenzofuranoyl (THDBF) bridge between the 2-oxygen and 4-oxygen of glucose on corilagin with a 3,6-O-(R)-hexahydroxydiphenoyl (HHDP) bridge, is described. The key features of the total synthesis are: 1) improvements of our previously reported method to synthesize corilagin; 2) establishment of the THDBF skeleton via an unusual intramolecular S_NAr reaction of an HHDP analogue, and 3) the application of a two-step bislactonization strategy for a HHDP bridge construction into the 2,4-O-THDBF bridge. Oxidative phenol coupling of 1,2,4-orthoacetyl-3,6-di-(4-O-benzylgalloyl)-α-d -glucopyranose and the orthoester cleavage of the coupling product without the pyranose-furanose ring transformation are key reactions for the improved synthesis of corilagin, which enabled the adequate supply of a corilagin precursor that was required to develop the mallotusinin synthesis. These established methods are expected to help develop the synthesis of other ellagitannins with a bridge between the two oxygens of corilagin.     

紫杉醇全合成

评论了紫杉醇合成了合成战略，合成路线，逆合成分析及展望，参考文献９篇。     

Synthesis of 1-TRiacontanol

Several studies describing the synthesis of 1-triacontanol have appeared¹ following the report² that application of 1-triacontanol (1), an active constituent of alfalfa (Medicago sativa L.), increased the yields of tomatoes, cucumber, lettuce, rice, corn and several other crop species. We detail here a convenient synthesis of 1-triacontanol, and the salient feature of this synthesis is that these reactions are inexpensive, simple and amenable to multigram synthesis.