共查询到20条相似文献,搜索用时 93 毫秒
1.
Newly developed, simple, low-cost and sensitive ion-selective electrodes have been proposed for determination of some antiepileptic
drugs such as lamotrigine, felbamate, and primidone in their pharmaceutical preparations as well as in biological fluids.
The electrodes are based on poly(vinyl chloride) membranes doped with drug–tetraphenyl borate (TPB) or drug–phosphotungstic
acid (PT) ion-pair complexes as molecular recognition materials. The novel electrodes displayed rapid Nernstian responses
with detection limits of approximately 10−7 M. Calibration graphs were linear over the ranges 5.2 × 10−7–1.0 × 10−3, 1.5 × 10−6–1.0 × 10−3, and 2.6 × 10−7–1.0 × 10−3 M for drug–TPB and 5.8 × 10−7–1.0 × 10−3, 1.8 × 10−7–1.0 × 10−3, and 6.6 × 10−7–1.0 × 10−3 M for drug–PT electrodes, respectively, with slopes ranging from 52.3 to 62.3 mV/decade. The membranes developed have potential
stability for up to 1 month and proved to be highly selective for the drugs investigated over other ions and excipients. The
results show that the selectivity of the ion-selective electrodes is influenced significantly by the plasticizer. The proposed
electrodes were successfully applied in the determination of these drugs in pharmaceutical preparations in four batches of
different expiry dates. Statistical Student’s t test and F test showed insignificant systematic error between the ion-selective electrode methods developed and a standard method. Comparison
of the results obtained using the proposed electrodes with those found using a reference method showed that the ion-selective
electrode technique is sensitive, reliable, and can be used with very good accuracy and high percentage recovery without pretreatment
procedures of the samples to minimize interfering matrix effects.
Figure Structure of lamotrigine, felbanate and primidone 相似文献
2.
A new p-tetra-butyl calix [6] arene-L-Histidine chemically modified glassy carbon electrode (BCH/GCE) has been proposed for simultaneous
investigation and determination of epinephrine (Ep) and serotonin (5-HT) by cyclic voltammetry (CV) and differential pulse
voltammetry (DPV). In potassium dihydrogen phosphate-borax (PDPB) buffer solution (pH 5.8), the anodic peaks of Ep and 5-HT
were observed at 0.27 and 0.45 V, respectively, with E up to 180 mV. The peak currents on the DP voltammogram are in a linear relationship with the concentrations of Ep in the
range of 1.0 × 10−6−1.30 × 10−4 M in the presence of 1.0 × 10−4 M 5-HT. A linear relationship was similarly found for 5-HT in the range 1.0 × 10−6− 1.40 × 10−4 M in the presence of 1.0 × 10−4 M Ep. It is found that Ep and 5-HT could be simultaneously determined with good sensitivity in the presence of 1.0 × 10−3 M ascorbic acid (AA). The developed method has been applied to the determination of Ep and 5-HT in synthetic samples with
satisfactory results.
The text was submitted by the authors in English. 相似文献
3.
Won-Sik Han Jang-Ki Kim Koo-Chun Chung Joo-Yeon Hong Jong-Ki Hong Jeong-Hoon Kim Tae-Kee Hong 《Journal of Analytical Chemistry》2010,65(10):1035-1040
Udenafil is an oral agent for treating male erectile dysfunction. The poly(aniline) solid contact selective electrodes for
udenafil have been fabricated from PVC cocktail solutions with three ion selective ion pairs. This solid contact electrode
contains three layers of Pt/electro-conductive poly(aniline) polymer/PVC film with an ionophore with a thickness of 2.5 ±
0.1 mm. We compared the slopes of EMF responses and the response range of a solid contact electrode based on Udenafil-TmCIPB
ion pair with those based on Udenafil-PMA and Udenafil-TPB ion pairs and showed that the response slopes were influenced by
plasticizers. The EMF response slopes of Udenafil-TmCIPB-based solid contact electrodes equalled 58.0 mV/decade (at 20 ± 0.2°C)
and their linear response dynamic ranges were 1.0 × 10−2∼1.0 × 10−5.85 M (r
2 = 0.9984). When electrodes with 6 different plasticizers based on Udenafil-TmCIPB were compared, as the dielectric constant
of PVC plasticizer increased, so was the response slope at the same time. Having applied the electrodes to artificial serum
directly, we could get same satisfactory results [Nernstian slope: 60.3 mV/decade, dynamic range: 1.0 × 10−2∼1.0 × 10−5.78 M (r
2 = 0.9978) in artificial serum]. Solid contact electrodes with Udenafil-TmCIPB have shown the best selectivity, reproducibility
of EMF, long-term stability, and short response time (< 20 s). 相似文献
4.
Wang-Zhuan Liu Xiao-Gang Wang Qing-Sheng Wu Ya-Ping Ding 《Journal of Analytical Chemistry》2009,64(1):54-58
A fast and convenient analytical technique has been suggested to detect dihydroxybenzene (DHB) isomers directly and simultaneously.
In 0.1 M HAc-NaAc buffer solution (pH 5.6), the reduction peaks of p -DHB and o -DHB were partly separated by differential pulse voltammetry at the glassy carbon electrode. By adding a surfactant (cetyl
pyridinium chloride) to enhance the detection sensitivity and using a semi-derivative technique to improve the separation,
p-DHB and o-DHB were detected simultaneously. The linear calibration ranges were 1.2 × 10−6 to 1.0 × 10−4 M for p -DHB and 8.2 × 10−7 to 1.0 × 10−4 M for o -DHB, with detection limits of 3.6 × 10−7 and 2.4 × 10−7 M, respectively. The proposed method has been applied to the direct determination of DHB isomers in water sample, and the
results were excellent.
The text was submitted by the authors in English. 相似文献
5.
Won-Sik Han Young-Hoon Lee Soon-Nyeo Lee Tae-Kee Hong 《Journal of Analytical Chemistry》2011,66(9):854-858
Iodide ion selective poly(aniline) solid contact electrode based on quinine-Cu ionophore as a sensing material has been successfully
developed. The electrode exhibits good linear response of 52.0 mV/decade (at 20 ± 0.2°C, r
2 = 0.9998) within the concentration range of 1 × 10−6.4–1 × 10−1.0 M KI. The composition of this electrode was quinine-Cu 2.0: PVC 30.0: bis(2-ethylhexyl)sebacate 68.0 (mass). This plasticizer
provides the best response characteristics. The electrode shows good selectivity for iodide ion in comparison with any other
anions and is suitable for use with aqueous solutions of pH 3.3–9.4. The standard deviations of the measured EMF difference
were ±1.4 and ±1.3 mV for iodide sample solutions of 1.0 × 10−2 M and 1.0 × 10−3 M, respectively. The stabilization time was less than 10 min and response time was less than 15 sec. 相似文献
6.
Y. Kobayashi H. Kakinuma D. Nagao Y. Ando T. Miyazaki M. Konno 《Journal of Sol-Gel Science and Technology》2008,47(1):16-22
This paper describes a method for fabrication of silica-coated Co–Pt alloy nanoparticles in a liquid phase process. The Co–Pt
nanoparticles were prepared from CoCl2 (4.2 × 10−5 M), H2PtCl6 (1.8 × 10−5 M), citric acid (4 × 10−4 M) and NaBH4 (1.2 × 10−2 M) with a Co:Pt mole ratio of 7:3. The silica coating was performed in water/ethanol solution with a silane coupling agent,
3-aminopropyltrimethoxysilane (8 × 10−5 M), and a silica source, tetraethoxyorthosilicate (7.2 × 10−4 M) in the presence of the Co–Pt nanoparticles. Observations with a transmittance electron microscope and a scanning transmission
electron microscope revealed that the Co-rich and Pt-rich nanoparticles were coated with silica. According to X-ray diffraction
measurements, core particles were crystallized to metallic Co crystallites and fcc Co–Pt alloy crystallites with annealing
in air at 300–500 °C. Magnetic properties of the silica-coated particles were strongly dependent on annealing temperature.
Maximum values of 11.4 emu/g-sample for saturation magnetization and 365 Oe for coercive field were obtained for the particles
annealed at 300 and 500 °C, respectively. Annealing at a temperature as high as 700 °C destroyed the coating structures because
of crystallization of silica shell, resulting in reduction in saturation magnetization and coercive field. 相似文献
7.
In the presence of carbonate and uranine, the chemiluminescent intensity from the reaction of luminol with hydrogen peroxide
was dramatically enhanced in a basic medium. Based on this fact and coupled with the technique of flow-injection analysis,
a highly sensitive method was developed for the determination of carbonate with a wide linear range. The method provided the
determination of carbonate with a wide linear range of 1.0 × 10−10–5.0 × 10−6 mol L−1 and a low detection limit (S/N = 3) of carbonate of 1.2 × 10−11 mol L−1. The average relative standard deviation for 1.0 × 10−9–9.0 × 10−7 mol L−1 of carbonate was 3.7% (n = 11). Combined with the wet oxidation of potassium persulfate, the method was applied to the simultaneous determination
of total inorganic carbon (TIC) and total organic carbon (TOC) in water. The linear ranges for TIC and TOC were 1.2 × 10−6–6.0 × 10−2 mg L−1 and 0.08–30 mg L−1 carbon, respectively. Recoveries of 97.4–106.4% for TIC and 96.0–98.5% for TOC were obtained by adding 5 or 50 mg L−1 of carbon to the water samples. The relative standard deviations (RSDs) were 2.6–4.8% for TIC and 4.6–6.6% for TOC (n = 5). The mechanism of the chemiluminescent reaction was also explored and a reasonable explanation about chemical energy
transfer from luminol to uranine was proposed.
Figure Chemiluminescence profiles in batch system. 1, Injection of 100 μL of K2CO3 into 1.0 mL luminol-1.0 mL H2O2 solution; 2-3 and 4-5, Injection in sequence of 100 μL of K2CO3 and 100 μL of uranine into 1.0 ml luminol-1.0 mL H2O2 solution; Cluminol = 1.0 × 10−7 mol/L, CH2O2 = 1.0 × 10−5 mol/L, Curanine = 1.0 × 10−5 mol/L, CK2CO3 = 1.0 × 10−7 mol/L except for 4-5 where CK2CO3 = 1.0 × 10−4 mol/L 相似文献
8.
A differential pulse voltammetric method for the determination of nitrate has been described, which is applicable to the
analysis of natural water samples with nitrate levels greater than 2.8 × 10−6 M. A reduction peak for the nitrate ions at a freshly copper plated glassy carbon electrode was observed at about −0.50 V
vs Ag ∣AgCl∣KClsatd electrode in a solution of 2.0 × 10−2 M Cu2+, 0.5 M H2SO4 and 1.0 × 10−3 M KCl and exploited for analytical purposes. The working linear range was established by regression analysis and found to
extend from 2.8 ×10−6 M to 8.0 × 10−5 M. The proposed method was applied for the determination of nitrate in natural waters. The detection limit of the method
was 2.8 × 10−6 M and the sensitivity was 0.9683 A·L/mol. The possible interferences by some ions such as phosphate, nitrite and some halides
were determined and found to lead to shifts of the peak position and increasing the peak heights.
Received March 15, 1999. Revision July 9, 1999. 相似文献
9.
Heterocyclic thiocarboxylic acids have been designed to prepare polymeric membrane ion-selective electrode (ISE) for Pb2+. Construction, response characteristic and application of the lead ISEs are investigated. Better results have been obtained
with membranes containing ligands L1∼L3 with bis(2-ethylhexyl) sebacate (DOS) as a plasticizer. Ionophores L1∼L3 are [(4,6-dimethyl-2-pyrimidinyl) thio] acetic acid (L1), (1,3,4-thiadiazole-2,5-diyldithio) diacetic acid (L2) and (1,3,4-thiadiazole-2,5-diyldithio) dipropionic acid (L3). The optimum electrodes have the composition of L1 (1.6): PVC (32.7): DOS (65.3): KT
p
ClPB (0.4) (w/w), L2 (1.0): PVC (32.8): DOS (66.0): KT
p
ClPB (0.2) (w/w), and L3 (1.0): PVC (32.7): DOS (65.4): KT
p
ClPB (0.9) (w/w). The optimized membrane electrodes work well over a wide range of concentrations (1.0 × 10−5 ∼1.0 × 10−2 M, 1.0 × 10−6 ∼1.0 × 10−2 M, and 1.0 × 10−6 ∼1.0 × 10−2 M) with the response slope of 27.4, 30.1 and 29.2 mV/decade, respectively. Potentiometric selectivities of the ISEs based
on L1 ∼ L3 for Pb2+ over other interfering ions are determined with the fix interference method. The electrodes display good selectivity over
a number of alkali, alkaline earth, transition and heavy metal ions. The lifetime of the electrodes is about 2 months and
their response time is 20 s. Applications of these electrodes for the determination of lead in real samples and as indicator
electrodes for potentiometric titration of Na2SO4 using Pb2+ solution are reported. 相似文献
10.
M. R. Ganjali P. Norouzi R. Dinarvand F. Faribod A. Moghimi 《Journal of Analytical Chemistry》2008,63(7):684-689
In this work, for the first time, we introduce a highly selective and sensitive Be(II) microsensor. 4-nitrobenzo-9-crown-3-ether
(NBCE) was used as a membrane-active component to prepare a Be(II)-selective polymeric membrane microelectrode. The electrode
exhibits a Nernstian response toward Be(II) ions over a very wide concentration range (1.0 × 10−4–1.0 × 10−10 M), with a detection limit of 3.5 × 10−11 M (∼350 pg/L). In fact, the electrode presents a fast response time in the whole concentration range (6 s). The proposed
microelectrode can be used for at least six weeks without any considerable divergence in the potentials. The proposed membrane
sensor revealed a selectivity toward Be(II) ions over a wide variety of other metal ions including common alkali, alkaline-earth,
and rare-earth ions. It could be used in the pH range of 3.0–11.5. The microelectrode was successfully used as an indicator
electrode for the titration of 20 mL of 1.0 × 10−6 M Be2+ solution with 1.0 × 10−4 M of EDTA. It was also applied to the direct determination of beryllium ions in beryl and binary mixtures.
The text was submitted by the authors in English. 相似文献
11.
Jun Yue Bai Liang Wang Hong Jing Wang Peng Fei Huang Yu Qing Zhao Sheng Di Fan 《Mikrochimica acta》2006,156(3-4):321-326
The electrochemical behavior of epinephrine (EP) at a mercaptoacetic acid (MAA) self-assembled monolayer modified gold electrode
was studied. The MAA/Au electrode is demonstrated to promote the electrochemical response of epinephrine by cyclic voltammetry.
The possible reaction mechanism is also discussed. The diffusion coefficient D of EP is 6.85 × 10−6 cm2 s−1. In 0.1 mol L−1 phosphate buffer (pH 7.20), a sensitive oxidation peak was observed at 0.177 V, and the peak current is proportional to the
concentration of EP in the range of 1.0 × 10−5–2.0 × 10−4 mol L−1 and 1.0 × 10−7–1.0 × 10−6 mol L−1. The detection limit is 5 × 10−8 mol L−1. The modified electrode is highly stable and can be applied to the determination of EP in practical injection samples. The
method is simple, quick, sensitive and accurate. 相似文献
12.
A nitric oxide biosensor based on the photovoltaic effect of nano titanium dioxide on hemoglobin was fabricated with high
sensitivity, selectivity, as well as stability. The linear detection concentration range was 5.0 × 10−6–4.0 × 10−4 M. The detection limit was 1.0 × 10−6 M with a sensitivity of 8 nA/μM. The possible coexisting compounds would not interfere with the nitric oxide detection.
The article is published in the original. 相似文献
13.
G. Veera Babu M. Palaniappa M. Jayalakshmi K. Balasubramanian 《Journal of Solid State Electrochemistry》2007,11(12):1705-1712
Graphite particles were coated with Ni–P by electroless deposition using a conventional bath consisting of a nickel salt and
hypophosphite. After 15 min of electroless deposition, the graphite particles were covered with 10 wt% nickel and 0.7–1.0 wt%
phosphorus as analysed by wet chemical method. Surface morphology was studied by scanning electron microscopy (SEM). Electrochemical
characterisation for the catalytic activity was done by cyclic voltammetry. Pure Ni powder and electroless Ni–P coated on
graphite were used as catalysts for the electro-oxidation of dextrose (1.8 × 10−3 to 4.5 × 10−3 M) in 0.1 M KOH solution. Comparative studies revealed that electroless Ni–P coated on graphite particles acted as a better
catalyst than pure Ni powder for catalytic reaction. 相似文献
14.
The electrocatalytic oxidation of quinine sulfate (QS) was investigated at a glassy carbon electrode, modified by a gel containing
multiwall carbon nanotubes (MWCNTs) and room-temperature ionic liquid of 1-Butyl-3-methylimidazolium hexafluorophate (BMIMPF6) in 0.10 M of phosphate buffer solution (PBS, pH 6.8). It was found that an irreversible anodic oxidation peak of QS with
E
pa as 0.99 V appeared at MWCNTs-RTIL/glassy carbon electrode (GCE). The electrode reaction process was a diffusion-controlled
one and the electrochemical oxidation involved two electrons transferring and two protons participation. Furthermore, the
charge-transfer coefficient (α), diffusion coefficient (D), and electrode reaction rate constant (k
f) of QS were found to be 0.87, 7.89 × 10−3 cm2⋅s−1 and 3.43 × 10−2 s−1, respectively. Under optimized conditions, linear calibration curves were obtained over the QS concentration range 3.0 × 10−6 to 1.0 × 10−4 M by square wave voltammetry, and the detection limit was found to be 0.44 μM based on the signal-to-noise ratio of 3. In
addition, the novel MWCNTs-RTIL/GCE was characterized by the electrochemical impedance spectroscopy and the proposed method
has been successfully applied in the electrochemical quantitative determination of quinine content in commercial injection
samples and the determination results could meet the requirement. 相似文献
15.
Naixing Wang Lei Wang Xuezhen Ren Wei Jiang Zhikun Si Huabin Zhou Miao Zhang Yuzhi Wang 《Mikrochimica acta》1999,132(1):17-23
The second derivative spectrophotometric method has been developed as a procedure for the determination of neodymium, holmium
and erbium in mixed rare earths. It was found that the 1-ethyl-6, 8-difluoro-7-(3-methyl-1-piperazinyl)-4-oxo-1,4- dihydro-3-quinoline
carboxylic acid forms stable complexes with neodymium, holmium and erbium ions in the pH 9.2–10.5 range. In the second derivative
spectra the optimum analytical signals for neodymium, holmium and erbium are at 576.2 (+)−574.5 (−)nm, 444.2 (+) −447.8 (−)nm
and 516.0 (+) −517.2(−)nm, respectively. Beer’s law is obeyed from 5.0×10−5 M to 2.5×10−4 M of neodymium, holmium and erbium. The quantification limits (10 Sb) were 1.2×10−5 M for Nd, 9.7×10−5 M for Ho and 3.0×10−6 M for Er.
Received April 22, 1998. Revision March 8, 1999. 相似文献
16.
Xiaomei Cao Yanhong Xu Liqiang Luo Yaping Ding Ying Zhang 《Journal of Solid State Electrochemistry》2010,14(5):829-834
A glassy carbon electrode (GCE) modified with the film composed of chitosan incorporating cetylpyridine bromide is constructed
and used to determine uric acid (UA) and ascorbic acid (AA) by differential pulse voltammetry (DPV). This modified electrode
shows efficient electrocatalytic activity and fairly selective separation for oxidation of AA and UA in mixture solution.
UA is catalyzed by this modified electrode in phosphate buffer solution (pH 4.0) with a decrease of 80 mV, while AA is catalyzed
with a decrease of 200 mV in overpotential compared to GCE, and the peak separation of oxidation between AA and UA is 260
mV, which is large enough to allow the determination of one in presence of the other. Under the optimum conditions, the anodic
peak currents (I
pa) of DPV are proportional to the concentration of UA in the range of 2.0 × 10−6 to 6.0 × 10−4 M, with the detection limit of 5.0 × 10−7 M at a signal-to-noise ratio of 3 (S/N = 3) and to that of AA in the range of 4.0 × 10−6 to 1.0 × 10−3 M, with the detection limit of 8.0 × 10−7 M (S/N = 3). 相似文献
17.
Chunhai Yang Shenghui Zhang Yingxuan Liu Wensheng Huang 《Frontiers of Chemistry in China》2008,3(3):353-358
A multi-wall carbon nanotubes (MWNTs)-Nafion film-coated glassy carbon electrode (GCE) was fabricated and the electrochemical
behavior of ofloxacin on the MWNTs-Nafion film-coated GCE were investigated by cyclic voltammetry (CV), linear sweep voltammetry
(LSV) and electrochemical impedance spectroscopy (EIS). The oxidation peak current of ofloxacin increased significantly on
the MWNTs-Nafion film modified GCE compared with that using a bare GCE. This nano-structured film electrode exhibited excellent
enhancement effects on the electrochemical oxidation of ofloxacin. A well-defined oxidation peak attributed to ofloxacin was
observed at 0.97 V and was applied to the determination of ofloxacin. The oxidation peak current was proportional to ofloxacin concentration
in the ranges 1.0 × 10−8 to 1.0 × 10−6 mol/L and 1.0 × 10−6 to 2.0 × 10−5 mol/L. A detection limit of 8.0 × 10−9 mol/L was obtained for 400 s accumulation at open circuit (S/N = 3). This method for the detection of ofloxacin in human
urine was satisfactory.
__________
Translated from Chinese Journal of Applied Chemistry, 2007, 24(5): 540–545 [译自: 应用化学] 相似文献
18.
Ai-Lin Liu Jia-Dong Wang Wei Chen Xing-Hua Xia Yuan-Zhong Chen Xin-Hua Lin 《Journal of Solid State Electrochemistry》2012,16(4):1343-1351
A simple, rapid, sensitive, and accurate method for simultaneous electrochemical determination of procaine and its metabolite
(p-aminobenzoic acid, PABA) for pharmaceutical quality control and pharmacokinetic research was developed using a graphite paste
electrode. The differential pulse voltammetric results revealed that procaine and p-aminobenzoic acid, respectively, showed well-defined anodic oxidation peaks on a carbon paste electrode with a current peak
separation of 155 mV at a scan rate of 100 mV s−1. This well separation of the current peaks for these two compounds in voltammetry enables us to simultaneously determine
them. Good linearity (r > 0.998) between oxidation peak current and concentration was obtained in the range of 5.0 × 10−7–5.0 × 10−5 M for procaine and 5.0 × 10−7–2.0 × 10−5 M for PABA in pH 4.50 acetate buffer solution. The detection limit for both analytes is 5 × 10−8 M (S/N = 3:1). The present voltammetric method has been successfully used to determine trace p-aminobenzoic acid in procaine hydrochloride injection and procaine in plasma with a linear relationship of current to its
concentration ranging from 1.0 × 10−6 to 5.0 × 10−5 M (correlation coefficient of 0.9981) with a low detection limit of 5.0 × 10−7 M (S/N = 3:1). This validated method is promising to the study of pharmacokinetics in Sprague–Dawley rat and rabbit plasma after
an intravenous administration of procaine hydrochloride injection. 相似文献
19.
A new simple and inexpensive optical chemical sensor for cadmium(II) ions is presented. The cadmium sensing system was prepared
by incorporating 2-amino-cyclopentene-1-dithiocarboxylic acid (ACDA) on a triacetylcellulose membrane. The absorption spectra of the optical sensor membrane in Cd(II) solution showed a maximum
peak at 430 nm. The proportionality in intensity of the membrane color on the optode to varying amounts of Cd(II) suggests
its potential applications for screening Cd(II) in aqueous samples by visual colorimetry. The sensor provided a wide concentration
range of 3.0 × 10−6–3.4 × 10−4 M of Cd(II) ions with a detection limit of 1.0 × 10−6 M (0.2 μg/mL). The relative standard deviations for eight replicate measurements of 8.0 × 10−6 and 5.0 × 10−5 M Cd(II) were 2.7 and 2.3%, respectively. The response time of the optode was 6 min. The influence of interfering ions on
the determination of 1.0 × 10−5 M Cd(II) was studied and the main interferences were removed by extraction method. The sensor was applied to the determination
of Cd(II) in water samples. 相似文献
20.
The main purpose of this study is to develop an inexpensive, simple, selective and especially sensitive modified carbon paste
electrode (MCPE) for the determination of dopamine (DA) in pharmaceutical and human serum samples. The carbon paste electrode (CPE) has been modified by using [N,N′-bis(2-pyridine carboxamido)-1,2-benzene] nickel(II) complex (Ni(II)bpb) and the electrochemical
behavior of the modified electrode has been studied by cyclic voltammetry. The modified electrode shows an excellent electrocatalytic
effect on the oxidation of DA. Under optimum conditions, calibration plots are found to be linear in the range of 7.0 × 10−7−1.0 × 10−5 M (r
2 = 0.9940) and 1.0 × 10−5−1.0 × 10−4 M (r2 = 0.9945); the detection limit is 6.2 × 10−8 M. The preparation of MCPE is very easy. The electrode can be renewed by simple polishing. The proposed method shows good
sensitivity, reproducibility (RSD ∼ 2.9%), high stability (more than two month) without any considerable change in response
and recovery for the determination of DA. The prepared electrode has been successfully applied to the voltammetric determination
of DA in pharmaceutical and biological samples.
The article is published in the original. 相似文献