共查询到20条相似文献,搜索用时 125 毫秒
1.
Islam H. El‐Azab 《Journal of heterocyclic chemistry》2013,50(Z1):E178-E188
Preparation of 4‐chloro‐3H‐benzo[b][1,4]diazepine‐2‐carbaldehyde 5 , which is used as a key intermediate in the synthesis of chalcones derivatives, via its condensation with some aromatic acetophenone derivatives under ethanol piperidine condition was described. Also illustrated was the reaction of such chalcones with available nucleophilics and reagents of active methylene group to afford new series of fused and isolated pyrazoles, isoxazolines pyrimidines, pyridines, triazolo[1,5‐a]pyrimidines, benzo[1,4]oxa(thia)zepines, and pyrido[1,2‐a]benzimidazoles incorporating 4‐chloro‐3H‐benzo[b][1,4]diazepine moiety, which have a potential pharmaceutical interest. Furthermore, condensation reaction of 4‐chloro‐3H‐benzo[b][1,4]diazepine‐2‐carbaldehyde with aromatic amine derivatives to afford the Schiff's bases was described. The C═N double bond of the latter compounds has been reacted with chloroketene to give β‐lactams and with sulfanylacetic acid to give the 2‐(4‐oxo‐1,3‐thiazolidinyl)‐substituted derivative. The structures of the newly prepared compounds were established by elemental analysis, IR, MS, and 1H NMR spectral analysis. 相似文献
2.
《Journal of heterocyclic chemistry》2017,54(2):1537-1542
The essential idea of the work in this article is mainly dependent on the use of bis‐hydrazonoyl halides for heterocyclic synthesis. The present work describes preparation and characterization of new bis‐thiazoles from reaction of bis‐hydrazonoyl chlorides with thiosemicarbazones. The synthetic Schemes for the final compounds are proposed and discussed. Structures of the final products were elucidated by elemental analyses and Fourier transform infrared, mass spectrometry, 1H, and 13C‐NMR spectra. 相似文献
3.
由邻苯二胺合成苯并咪唑、喹喔啉以及1-H-2,3-二氢1,5-苯并氮杂卓 总被引:1,自引:0,他引:1
A series of benzo-fused heteroaromatic compounds with 5-, 6- and 7-membered tings, such as benzimidazole,quinoxaline and 1H-1,5-benzodiazepine derivatives, were synthesized through condensation reaction of o-pheny1-enediamine with ary1 aldehydes or ketones. The experimental conditions were carefully examined, and the products were characterized by ^1H NMR, ^13C NMR, MS, IR and elemental analyses. In addition, the structure of a benzodiazaepine derivative with 7-membered ring was confirmed by single crystal X-ray diffraction analysis. 相似文献
4.
K. J. Jarag A. R. Jagtap B. N. Borse S. R. Shukla G. S. Shankarling 《Journal of heterocyclic chemistry》2012,49(5):1196-1201
The novel 1,4‐diphenethyl‐1,2,3,4‐tetrahydro‐7‐methoxyquinoxalin‐6‐carbaldehyde was synthesized by reductive alkylation of 6‐methoxy quinoxaline with phenyl acetic acid and was further subjected to Knoevenagel condensation with various active methylene compounds to synthesize novel styryl colorants. Photophysical properties of styryl colorants were studied using UV–visible and fluorescence spectroscopy. These colorants displayed orange to violet hue and showed fluorescence emission maxima in the region of 560–640 nm, and displayed a large Stokes shift (85–104 nm). Compounds were subjected to thermogravimetric analysis which showed excellent stability up to 310°C. These styryl compounds were evaluated for their antimicrobial study as antifungal against Candida albicans C. albicans and Aspergillus niger and antibacterial against Escherichia coli and Staphylococcus aureus. The results revealed good antimicrobial activity against tested organisms. The synthesized chromophores were characterized using elemental analysis, FTIR, 13C‐NMR and 1H‐NMR spectroscopy and mass spectrometry. 相似文献
5.
Synthesis,characterization and solid‐phase extraction properties of novel bis(diazo‐azomethine) ligands supported on mesoporous silica
下载免费PDF全文
![点击此处可从《应用有机金属化学》网站下载免费的PDF全文](/ch/ext_images/free.gif)
The novel mesoporous silica‐supported bis(diazo‐azomethine) compounds have been synthesized and characterized successively. In the first step, 1,3‐phenylenedimethanamine and 4,4′‐diaminodiphenylmethane were diazotized, and the obtained bis(diazonium) cations were coupled with 2,4‐dihydroxybenzaldehyde. The synthesized bis(diazo‐carbonyl) compounds, 5,5′‐((1,3‐phenylenebis(methylene))bis(diazene‐2,1‐diyl))bis(2,4‐dihydroxybenzaldehyde) (A1) and 5,5′‐((methylenebis(4,1‐phenylene))bis(diazene‐2,1‐diyl))bis(2,4‐dihydroxybenzaldehyde) (A2) were chemically supported on amino‐modified silica‐gel (as L1 and L2). Elemental analysis, liquid chromatography‐mass spectroscopy, liquid‐phase NMR (1H and 13C) and solid‐phase NMR (CP‐MAS 29Si and 13C), FT‐IR, TG/DTA, scanning electron microscopy and energy‐dispersive X‐ray spectroscopy techniques were used for characterizations of all the synthesized compounds. The syringe and batch techniques were applied for the solid‐phase extraction properties of Pb(II), Cu(II), Cd(II) and Cr(III) ions using an inductively coupled plasma‐atomic emission spectroscopy instrument. The recoveries of Pb(II), Cu(II), Cd(II) and Cr(III) ions have been achieved to 95–99% with the (RSDs) of ± 2–3% in optimum conditions. 相似文献
6.
Tom Szotkowski Filip Bure Old
ich Pytela Ji
í Kulhnek Zdenk Trvní
ek 《Journal of heterocyclic chemistry》2006,43(6):1583-1589
7.
This study discusses the synthesis of two new 2‐hydroxyethyl substituted N‐heterocyclic carbene (NHC) precursors. The NHC precursors were prepared from 1‐(alkyl/aryl)benzimidazole and alkyl halides. They were characterized using 1H NMR, 13C NMR, FT‐IR, UV–Vis spectroscopy, and elemental analysis techniques. Molecular and crystal structures of 1 and 2 were determined using the single‐crystal X‐ray diffraction method. Crystal structure of the compounds features NHC precursors and chloride anions. Additionally in 2 , the asymmetric unit has a water molecule, which forms a tetrameric chloride‐hydrate assembly with the chloride anion. The chloride anions play an important role in the stabilization of crystal structures to form a two‐dimensional supramolecular architecture. The 3D Hirshfeld surface and the associated 2D fingerprint plots were also drawn to gain insights into the behavior of the interactions in the compounds. 相似文献
8.
设计合成了4个8-羟基喹啉共轭联接芳香杂环化合物来研究它们在有机发光材料和荧光探针的潜在应用。用IR, 1H NMR, 13C NMR, MS, UV确认了这些新化合物的结构。测定了化合物1-4的荧光性质,发光衰变时间和量子产率,并用密度泛函方法研究了4个化合物的几何结构和荧光发射波长的关系。在调控骨髓间充质干细胞增殖以及清除DPPH自由基的活性测试结果表明,这些化合物具有促进小鼠骨髓间充质干细胞的增殖的活性及良好的抗氧化性。 相似文献
9.
A series of variously substituted 1,3‐thiazole heterocyclic compounds ( 3a – 3d ) were prepared by base‐catalyzed S‐cyclization of corresponding 2,4‐dichloro‐N‐{[(4‐substitutedphenyl)amino]carbonothioyl}benzamide ( 2a – 2d ) with acetophenone in the presence of bromine. The structure of all compounds was established by IR, 1H‐NMR, 13C‐NMR, elemental analysis, and X‐ray crystallographic analysis. 相似文献
10.
Andrei V. Afonin Igor A. Ushakov Alexander V. Vashchenko Dmitry E. Simonenko Andrei V. Ivanov Alexander M. Vasil'tsov Al'bina I. Mikhaleva Boris A. Trofimov 《Magnetic resonance in chemistry : MRC》2009,47(2):105-112
According to the 1H, 13C and 15N NMR spectroscopic data and DFT calculations, the E‐isomer of 1‐vinylpyrrole‐2‐carbaldehyde adopts preferable conformation with the anti‐orientation of the vinyl group relative to the carbaldehyde oxime group and with the syn‐arrangement of the carbaldehyde oxime group with reference to the pyrrole ring. This conformation is stabilized by the C? H···N intramolecular hydrogen bond between the α‐hydrogen of the vinyl group and the oxime group nitrogen, which causes a pronounced high‐frequency shift of the α‐hydrogen signal in 1H NMR (~0.5 ppm) and an increase in the corresponding one‐bond 13C–1H coupling constant (ca 4 Hz). In the Z‐isomer, the carbaldehyde oxime group turns to the anti‐position with respect to the pyrrole ring. The C? H···O intramolecular hydrogen bond between the H‐3 hydrogen of the pyrrole ring and the oxime group oxygen is realized in this case. Due to such hydrogen bonding, the H‐3 hydrogen resonance is shifted to a higher frequency by about 1 ppm and the one‐bond 13C–1H coupling constant for this proton increases by ~5 Hz. Copyright © 2008 John Wiley & Sons, Ltd. 相似文献
11.
New Chiral and Achiral Imines and Bisimines Derived from 2‐Phenyl‐1H‐imidazole‐4‐carbaldehyde. Synthesis,Structural Studies and Complexation Stability Constants
下载免费PDF全文
![点击此处可从《Journal of heterocyclic chemistry》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Synthesis and properties of new imines and bisimines derived from 2‐phenyl‐1H‐imidazole‐4‐carbaldehyde and amines/diamines were studied. (2‐Phenyl‐1H‐imidazole‐4‐yl)methanol was oxidized to 2‐phenyl‐1H‐imidazole‐4‐carbaldehyde with better yield 55% by the modification of literature procedure. This aldehyde was condensed with the following achiral and chiral amines or 1,2‐diamines: ethanamine, propan‐1‐amine, butan‐1‐amine, 2‐methylpropan‐1‐amine, cyclohexanamine, (2R)‐ and (2S)‐3‐methylbutan‐2‐amine, (1R)‐ and (1S)‐1‐cyclohexylethanamine, (S)‐1‐aminopropan‐2‐ol, (S)‐1‐(2‐phenyl‐1H‐imidazol‐4‐yl)ethanamine, (S)‐1‐(2‐phenyl‐1H‐imidazol‐4‐yl)‐2‐methylpropan‐1‐amine, (S)‐1‐(2‐phenyl‐1H‐imidazol‐4‐yl)‐3‐methylbutan‐1‐amine, ethane‐1,2‐diamine, and (1R,2R)‐ and (1S,2S)‐cyclohexane‐1,2‐diamine. Sixteen condensation products, especially chiral imines and bisimines, were prepared by founded procedures in 45–99% of yields and characterized by the 1H NMR spectroscopy in solution, mass spectrometry, and elemental analyses. The optical rotation values in the case of chiral ones were also observed. Stability constants of Cu(II) complexes of selected prepared imines/bisimines were determined. 相似文献
12.
Synthesis and Antimicrobial Activity of Some Novel Hydrazide,Pyrazole, Triazine,Isoxazole, and Pyrimidine Derivatives
下载免费PDF全文
![点击此处可从《Journal of heterocyclic chemistry》网站下载免费的PDF全文](/ch/ext_images/free.gif)
In continuation of our efforts to find a new class of antimicrobial agents, a series of pyrazole, 1,2,4‐triazine, isoxazole, pyrimidine, and other related products containing a hydrazide moiety were prepared via the reaction of 2‐cyano‐N‐((2‐methoxynaphthalen‐1‐yl)methylene) acetohydrazide ( 1 ) with appropriate chemical reagents. These compounds were evaluated for their antimicrobial activities, and also their minimum inhibitory concentration against most of test organisms was performed. Among the tested compounds 4 , 5 , 6 , and 16 displayed excellent antimicrobial activity. All the synthesized products were confirmed by elemental analysis, IR, 1H‐NMR, 13C‐NMR, and mass spectral data. 相似文献
13.
Synthesis of Novel 1,2,4‐oxadiazoline Derivatives Containing Quinoline Moiety by 1,3‐Dipolar Cycloaddition
下载免费PDF全文
![点击此处可从《Journal of heterocyclic chemistry》网站下载免费的PDF全文](/ch/ext_images/free.gif)
A series of novel 1,2,4‐oxadiazoline derivatives containing 2‐(1,2,4‐triazol‐1‐yl)quinoline were synthesized by the reaction of imines with benzohydroximinoyl chlorides in the presence of Et3N via 1,3‐diplolar cycloaddition reaction. The structures of the target compounds were confirmed by IR, 1H NMR, MS, elemental, and X‐ray crystallographic analysis. 相似文献
14.
A series of methylenebis(phenyl-1,5-benzothiazepine)s 4 and methylenebis(benzofuryl-1,5-benzothiazepine)s 5 were prepared by the reaction of methylene-bis-chalcones 3 with 2-aminothiophenol for 4 and followed by the condensation with chloroacetone for 5. The structures of the synthesized compounds have been confirmed by their IR, 1H NMR, 13C NMR, MS and elemental analyses. All the synthesized compounds were tested for their antimicrobial activity against Gram-positive, Gram-negative bacteria and fungi. To elucidate the essential structural requirements for the antimicrobial activity, the preliminary structure-activity relationship has been described. Among the compounds tested, the dimeric compounds 4f, 4g, 5f and 5g were found to be most active against Bacillus subtilis, Bacillus sphaericus, Staphylococcus aureus, Klebsiella aerogenes and Chromobacterium violaceum. Similarly these dimeric compounds showed potent antifungal activity against Candida albicans, Aspergillus fumigatus, Trichophyton rubrum, and Trichophyton mentagrophytes. It is interesting to note that the dimeric compounds with substituents of heterocyclic ring at the 4th position of benzothiazepine system displayed notable antibacterial activity equal to that of streptomycin and penicillin. Further, the activity of all the dimeric compounds was compared with that of their monomeric compounds, and it is interesting to note that almost all the dimeric compounds showed enhanced activity than their monomeric compounds. 相似文献
15.
Nickel‐Catalyzed Synthesis of N‐Aryl‐1,2‐dihydropyridines by [2+2+2] Cycloaddition of Imines with Alkynes through T‐Shaped 14‐Electron Aza‐Nickelacycle Key Intermediates
下载免费PDF全文
![点击此处可从《Chemistry (Weinheim an der Bergstrasse, Germany)》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Dr. Yoichi Hoshimoto Tomoya Ohata Dr. Masato Ohashi Prof. Dr. Sensuke Ogoshi 《Chemistry (Weinheim an der Bergstrasse, Germany)》2014,20(14):4105-4110
Despite there being a straightforward approach for the synthesis of 1,2‐dihydropyridines, the transition‐metal‐catalyzed [2+2+2] cycloaddition reaction of imines with alkynes has been achieved only with imines containing an N‐sulfonyl or ‐pyridyl group. Considering the importance of 1,2‐dihydropyridines as useful intermediates in the preparation of a wide range of valuable organic molecules, it would be very worthwhile to provide novel strategies to expand the scope of imines. Herein we report a successful expansion of the scope of imines in nickel‐catalyzed [2+2+2] cycloaddition reactions with alkynes. In the presence of a nickel(0)/PCy3 catalyst, a reaction with N‐benzylidene‐P,P‐diphenylphosphinic amide was developed. Moreover, an application of N‐aryl imines to the reaction was also achieved by adopting N‐heterocyclic carbene ligands. The isolation of an (η2‐N‐aryl imine)nickel(0) complex containing a 14‐electron nickel(0) center and a T‐shaped 14‐electron five‐membered aza‐nickelacycle is shown. These would be considered as key intermediates of the reaction. The structure of these complexes was unambiguously determined by NMR spectroscopy and X‐ray analyses. 相似文献
16.
《Journal of heterocyclic chemistry》2018,55(6):1291-1307
A series of N‐containing heterocyclic compounds have been synthesized using approaches such as the well‐known Knorr synthesis, and a facile N‐alkylation method. This series of compounds includes pyrazole derivatives, tris(2‐benzimidazolylmethyl)amine derivatives, and “pincer” ligands. Characterization methods include 1H NMR, FT‐IR, CHN analyses, UV‐vis spectroscopy, and fluorimetry, while X‐ray crystal structures are reported for most of the compounds. The crystallographic results affirm a 13C NMR method for isomer assignment of substituted pyrazoles. 相似文献
17.
Wafaa S. Hamama Hamada G. El‐Gohary Mamdouh Soliman Hanfi H. Zoorob 《Journal of heterocyclic chemistry》2012,49(3):543-554
This research work describes the synthesis and biological properties of some novel isolated or fused heterocyclic ring systems with pyrazole, for example; enaminones containing pyrazolone ring photochromic functional unit, 4‐[(4‐chlorophenylamino)methylene]‐3‐methyl‐1‐phenyl‐1H‐pyrazol‐5(4H)‐one (3) and some analogous derivatives 4, 9, and 10, also as pyrazolo[3,4‐b]pyridine, pyrazolo[3,4‐b]quinoline, pyrazolo[3′,4′:4,5]thieno[2,3‐c]pyrazoline and pyrazolo[3,4‐c]pyrazole were synthesized and characterized. Newly synthesized compounds were characterized by IR, 1H NMR, 13C NMR, mass spectral data and quantum mechanical calculations. Selected products were tested for their antibacterial and antitumor agents. 相似文献
18.
Vakhid A. Mamedov Nataliya A. Zhukova Milyausha S. Kadyrova Rezeda R. Fazleeva Olga B. Bazanova Tat'yana N. Beschastnova Aidar T. Gubaidullin Il'dar Kh. Rizvanov Vitaliy V. Yanilkin Shamil K. Latypov Oleg G. Sinyashin 《Journal of heterocyclic chemistry》2020,57(6):2466-2479
The new α,α′-diimine ligands with benzimidazole moiety were synthesized based on the rearrangement of 3-aroylquinoxalin-2(1H)-ones when exposed to 4,5-diamino-2,1,3-benzoxadiazole, 4,5-diamino-2,1,3-benzothiadiazole and 5,6-diaminoquinoxaline. Among them, we report the first examples of the new heterocyclic system namely benzo[4′,5′]imidazo[1′,2′:1,2]quinolino[3,4-b and 4,3-b][1,2,5]oxadiazolo[3,4-f]quinoxalines, which exhibits an interesting electrochemical behavior. All compounds were fully characterized by IR, 1H and 13C NMR spectroscopies, and mass spectrometry. 相似文献
19.
Ismail I. Althagafi Amr S. Abouzied Thoraya A. Farghaly Nadia T. Al‐Qurashi Mohammad Y. Alfaifi Mohamed R. Shaaban Mohamed R. Abdel Aziz 《Journal of heterocyclic chemistry》2019,56(2):391-399
A facile access to novel bis‐(indoline‐2,3‐dione) was achieved via reactions of isatin with 1,3‐dibromopropane. The utility of the versatile bis‐(indoline‐2,3‐dione) in the design of new multifunctional building blocks using condensation with hydrazine derivatives was demonstrated. Moreover, a new series of bis‐thiazoles and bis‐thiazol‐4(5H)‐ones were synthesized by the reaction of bis‐thiosemicarbazone derivative with various derivatives of hydrazonoyl halides. The calculations derived from X‐ray diffraction patterns indicated the nanosize of the newly designed compounds. The spectral data of the formed compounds were established their structures. Also, the cytotoxic activity of the produced derivatives was screened against line MCF‐7 (breast cancer cell). It was found that four derivatives from nine investigated compounds showed activity more potent than the standard drug used by 20 times in some cases. 相似文献
20.
Chiral 2‐amino‐butanols ( 4 and 5 ) were obtained via the isolation of diastereomeric salt. Then, chiral compounds ( 6 – 9) were synthesized by a sequential procedure involving condensation of chiral 2‐amino‐butanol with ketone and dichloroacetyl chloride. All the compounds were characterized by IR, 1H NMR, 13C NMR, and element analysis. The absolute configurations of ( S )‐ 8 was determined by X‐ray crystallography. 相似文献