共查询到20条相似文献,搜索用时 15 毫秒
1.
V. V. Lipson S. M. Desenko M. G. Shirobokova V. V. Borodina V. I. Musatov 《Chemistry of Heterocyclic Compounds》2005,41(4):492-495
The hydrolysis, oxidation, reduction, alkylation, formylation, and nitrosation reactions of 2-methyl-5,7-diphenyl-6,7-dihydropyrazolo[1,5-a]pyrimidine have been studied.__________Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 4, pp. 577–581, April, 2005. 相似文献
2.
V. V. Lipson S. M. Desenko V. V. Borodina M. G. Shirobokova 《Chemistry of Heterocyclic Compounds》2007,43(12):1544-1550
The cyclocondensation of 3-amino-4-cyanopyrazole and 3-amino-4-ethoxycarbonylpyrazole with 1,3-diaryl-2,3-propen-1-ones gives
the corresponding 3-substituted 5,7-diaryl-4,7(6,7)-dihydropyrazolo[1,5-a]pyrimidines. Their tautomeric composition in solution
has been investigated by 1H NMR.
__________
Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 12, pp. 1824–1832, December, 2007. 相似文献
3.
V. N. Britsun A. N. Esipenko V. V. Piroghenko M. O. Lozinskii 《Chemistry of Heterocyclic Compounds》2008,44(8):979-984
[3+3] Cyclocondensation of 5-benzoyl-3-ethoxycarbonyl-6-methylthio-1-R-1,2-dihydropyrid-2-ones with heterocyclic N,N-and N,C-1,3-dinucleophiles
proceeds regioselectively to give a series of new tri-and tetracyclic heterosystems, viz. derivatives of 5,6-dihydropyrazolo[1,5-a]pyrido[2,3-d]pyrimidin-6-one,
1,2-dihydropyrido[2,3-d]pyrido[2′,3′: 3,4]pyrazolo[1,5-a]pyrimidin-2-one, 8,9-dihydro-5H-pyrido-[2,3-d]thiazolo[3,2-a]pyrimidin-8-one,
1,2-dihydrobenzo[4,5]imidazo[1,2-a]pyrido[2,3-d]pyrimidin-2-one, and 1,2-dihydrobenzo[4,5]imidazo[1,2-g][1,6]naphthyridin-2-one. 相似文献
4.
Gol Ravindra M. Khatri Taslimahemad T. Barot Vijaykumar M. 《Chemistry of Heterocyclic Compounds》2019,55(3):246-253
Chemistry of Heterocyclic Compounds - Efficient and regioselective on-water synthesis of variously substituted 5-amino-4,7-dihydropyrazolo[1,5-a]pyrimidine-6-carbonitriles and... 相似文献
5.
Pavel V. Pasternak 《Journal of fluorine chemistry》2004,125(12):1853-1868
A new CF2X-analogue of 1,1-bis(trifluoromethyl)-2,2-dicyanoethylene (X = P(O)(OEt)2), diethyl (1,1-difluoro-3,3-dicyano-2-trifluoromethylallyl)phosphonate, has been synthesized from diethoxyphosphoryl pentafluoroacetone 1. A similar phosphoryl analogue of ethyl 3,3-dicyano-2-trifluoromethylacrylate, ethyl 3,3-dicyano-2-[(diethoxyphosphoryl)difluoromethyl]acrylate, has been obtained from ethyl 3-(diethoxyphosphoryl)-3,3-difluoro-2-oxopropionate 2. By heterocyclization of these new ethylenes with 3-methyl-2-pyrazoline-5-ones, 3(5)-aminopyrazoles, dimedone, 2-aminopyridines, 1-aryl-3-methyl-5-aminopyrazoles, 1,3,3-trimethylisoquinolines, as well as by condensation with anilines and ketones, the difluoromethylphosphonate-substituted derivatives of 1,4-dihydropyrano[2,3-c]pyrazole, 4,5-dihydropyrazolo[1,5-a]pyrimidine, 5,6,7,8-tetrahydro-4H-chromene, 2H-pyrido[1,2-a]pyrimidine, 4,7-dihydro-1H-pyrazolo[3,4-b]pyridine, 1,4-dihydropyridine, 4,5,6,7-tetrahydro-1H-[1]pyrindine, 1,4,5,6,7,8-hexahydroquinoline, and 6,7-dihydro-2H-pyrido[2,1-a]isoquinoline have been obtained in one stage. 相似文献
6.
Regioselective formylation behavior has been found in the reaction of pyrazolo[3,4-b]pyridines and pyrazolo[1,5-a]pyrimidines via Vilsmeier-Haack conditions. While the 4,5- and 6,7-dihydro derivatives afforded pyrazolo[3,4-b]pyridine-5-carbaldehydes and 4,7-dihydropyrazolo[1,5-a]pyrimidine-3,6-dicarbaldehydes, respectively, the aromatic analogs rendered the pyrazolo[1,5-a]pyrimidine-3-carbaldehyde only, and no reaction took place at the pyrazolopyridine derivatives. 相似文献
7.
Jairo Quiroga Braulio Insuasty Ricardo Rincon Marina Larrahondo Norbert Hanold Herbert Meier 《Journal of heterocyclic chemistry》1994,31(6):1333-1335
Cyclocondensation reactions of the pyrazol-5-amine 1 and the 1-aryl-3-phenyl-2-propen-1-ones 2a-d yield the 6,7-dihydropyrazolo[1,5-a]pyrimidines 7a-d . Whereas 7a-c can be isolated in pure state, 7d is subjected to a spontaneous oxidation. 相似文献
8.
9.
T Shiota T Yamamori K Sakai M Kiyokawa T Honma M Ogawa K Hayashi N Ishizuka K Matsumura M Hara M Fujimoto T Kawabata S Nakajima 《Chemical & pharmaceutical bulletin》1999,47(7):928-938
We have already reported 7-oxo-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carboxylic acid derivatives, which are potent in vitro angiotensin II (AII) antagonists, but have no oral antihypertensive activity. Removal of the carboxylic acid and replacement of the heteroaromatic system afforded potent in vitro antagonists. Removal of the carbonyl oxygen and changing the position of the biphenyltetrazole substituent were critical to the display of oral activity. To improve the in vitro and oral activities, modifications were made of the substituents at the 3- and 5-positions of the pyrazolo[1,5-a]pyrimidine. Structure-activity studies showed the methyl substituent at the 3-position to be essential for potent in vivo activity. We present the design, syntheses, and biological data of a series of pyrazolo[1,5-a]pyrimidine derivatives, which are orally active AII receptor antagonists. 相似文献
10.
V. A. Makarov N. P. Solov'eva O. B. Ryabova V. G. Granik 《Chemistry of Heterocyclic Compounds》2000,36(1):65-69
Two major compounds are formed in the reaction of 3,5-diamino-4-nitropyrazole with acetoacetic ester: 2-amino-5-methyl-3-nitro-4,7-dihydropyrazolo[1,5-a]pyrimidin-7-one and 3-amino-5-(-hydroxycrotonyl)amino-4-nitropyrazole. The latter is converted to bicyclic dihydropyrazolo[1,5-a]-pyrimidinone in solutions with heating.State Science Center of the Russian Federation NIOPIK (Scientific Research Institute of Organic Intermediates and Dyes), Moscow 103787Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 1, pp. 73–77, January, 2000. 相似文献
11.
Ihsan A. Shehata 《Monatshefte für Chemie / Chemical Monthly》1990,121(12):1017-1021
Summary Preparations of the novel fused dimethoxyquinoline derivatives of furo[2,3-b]quinoline (5),s-triazolo[4,3-a]quinoline (8) and tetrazolo[1,5-a]quinoline (10) from 6,7-dimethoxy-3-car-boxyquinoline-1-oxide (1) are reported.
Synthese kondensierter Chinolinderivate
Zusammenfassung Die Synthese der neuen kondensierten Dimethoxy-Chinolinderivate Furo[2,3-b]chinolin (5),s-Triazolo[4,3-a]chinolin (8) und Tetrazolo[1,5-a]chinolin (10) aus 6,7-Dimethoxy-3-carboxychinolin-1-oxid (1) wird beschrieben.相似文献
12.
O. V. Khilya T. A. Volovnenko Yu. M. Volovenko 《Chemistry of Heterocyclic Compounds》2006,42(10):1311-1324
The reaction of 4-oxo-3,4-dihydroquinazolyl-and benzimidazolylacetonitriles with 2-chloro-2-quinolinecarbaldehydes and 1-aryl-5-chloro-3-methyl-1H-pyrazole-4-carbaldehydes
gave the corresponding 3-(2-chloro-3-quinolyl)-2-(4-oxo-3,4-dihydro-2-quinazolyl)-2-propenenitriles and 3-(1-aryl-5-chloro-3-methyl-1H-4-pyrazolyl)-2-hetaryl-2-propenenitriles.
Intramolecular cyclization of these compounds gives 15-oxo-15H-benzo[6,7][1,8]naphthyridino[2,1-b]quinazoline-6-carbonitriles,
1-aryl-3-methyl-11-oxo-1,11-dihydropyrazolo[4′,3′:5,6]pyrido[2,1-b]quinazoline-5-carbonitriles, and 1-aryl-3-methyl-1H-benzo[4,5]imidazo[1,2-a]pyrazolo[4,3-e]pyridine-5-carbonitriles. 相似文献
13.
Jairo Quiroga Braulio Insuasty Angelina Hormaza Daniela Gamenara Laura Dominguez Jenny Saldaa 《Journal of heterocyclic chemistry》1999,36(1):11-13
Several new pyrazolo[1,5-a]pyrimidines were obtained from the reaction of 1H-5-amino-3-phenylpyrazole ( 1 ) with β-dimethylaminopropiophenones 2 in pyridine. The structure elucidation of 6,7-dihydropyrazolo[1,5-a]pyrimidines 3 is based on nmr measurements. These compounds showed moderate anthelmintic in vitro activity against the Nipposirongylus brasiliensis model. 相似文献
14.
S. M. Desenko V. D. Orlov V. V. Lipson O. V. Shishkin S. V. Lindeman Yu. T. Struchkov 《Chemistry of Heterocyclic Compounds》1991,27(11):1242-1246
5-Aryl-substituted 4,7(6,7)-dihydro-1,2,4-triazolo[1,5-a]pyrimidines were obtained by condensation of 3-amino-1,2,4-triazole with -dimethylaminopropiophenone hydrochlorides or crotophenone. The effect of steric and electronic factors on the position of the imine-enamine equilibrium in solutions of the synthesized substances is examined. 5-Phenyl-4,7-dihydro-1,2,4-triazolo[1,5-a]pyriniidine was subjected to x-ray diffraction analysis.See [1] for Communication 2.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 11, pp. 1539–1544, November, 1991. 相似文献
15.
5,7-Diaryl-4,7(6,7)-dihydrotetrazolo[1,5-a]pyrimidines were synthesized by the cyclocondensation of 5-aminotetrazole with chalcones. The tautomerism of the compounds obtained is discussed.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 11, pp. 1489–1493, November, 1988. 相似文献
16.
S. M. Desenko V. D. Orlov O. V. Shishkin V. V. Lipson S. V. Lindeman Yu. T. Struchkov 《Chemistry of Heterocyclic Compounds》1992,28(7):776-778
The x-ray structure is solved and the three-dimensional structure is analyzed for 5-(4-dimethylaminophenyl)-7phenyl-6,7-dihydro-1,2,4-triazolo[1,5-a]pyrimidine. Its reverse isomerization into the 4,7-dihydro species is studiedTranslated from Khimiya Geterotsiklicheskikh Soedinenii, No. 7, pp. 933–936, July, 1992. 相似文献
17.
Vunnam Srinivasulu Kim D. Janda Imad A. Abu-Yousef Matthew John OConnor Taleb H. Al-Tel 《Tetrahedron》2017,73(15):2139-2150
An efficient CuI-L-proline catalyzed one-pot synthesis was developed to generate a collection of skeletally diverse heterocyclic ring systems with sizes ranging from 6 to 9. A salient feature of this design strategy is its modular synthetic utility using an SN2 reaction followed by a microwave assisted CuI-L-proline hetero-arylation, which has granted access to a series of heterocyclic frameworks including: benzo[e]pyrrolo[1,2-a][1,4]diazepin, benzo[e]pyrrolo[1,2-a][1,4]diazocin, benzo[e]pyrido[1,2-a][1,4]diazocinones, dibenzo[b,f][1,5]diazoninones, dihydrodibenzo[b,e][1,4]thiazepine, dibenzo[b,e][1,4]thiazocine and benzo[6,7][1,4]diazepino[1,2-a]indole. Moreover, the synthetic procedures described herein, allows rapid entries to synthetically challenging medium-sized heterocyclic systems with good overall yields. 相似文献
18.
G. G. Danagulyan A. D. Mkrtchyan G. A. Panosyan 《Chemistry of Heterocyclic Compounds》2005,41(4):485-491
Condensation in ethanol of ethyl ethoxymethyleneacetoacetate with systems containing an amidine fragment (substituted 3-aminopyrazoles and 3-amino-1,2,4-triazole) gave 6-carbethoxy-7-methylpyrazolo[1,5-a]pyrimidines. Addition of base to solutions of the obtained bicyclic carbethoxy derivatives in the course of several minutes caused rearrangement to 6-acetyl-7-hydroxypyrazolo[1,5-a]pyrimidine and 6-acetyl-7-hydroxy-1,2,4-triazolo[1,5-a]pyrimidine respectively. A more prolonged refluxing in 15% aqueous alcohol solution of base caused 6-carbethoxy-7-methyl-2-phenylpyrazolo[1,5-a]pyrimidine and 6-acetyl-7-hydroxy-2-phenylpyrazolo[1,5-a]pyrimidine to recyclize to 7-methylpyrazolo[1,5-a]pyrimidine.__________Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 4, pp. 569–576, April, 2005. 相似文献
19.
[reaction: see text] A novel route to highly substituted chiral 6,7-dihydro-5H-imidazo[1,5-a]pyrazine-8-ones starting from Meldrum's acid is disclosed. The key features of the methodology are the incorporation of amino esters as a chiral pool and facile mild intramolecular cyclization to form the pyrazine ring. Incorporation of various substituents at different stages of the synthesis from various building block sets makes this methodology readily amenable to parallel synthesis. 相似文献
20.
Yasuyoshi Miki Osamu Tomii Hayami Nakao Mayumi Kubo Hiroko Hachiken Shoji Takemura Masazumi Ikeda 《Journal of heterocyclic chemistry》1988,25(1):327-331
Treatment of 3-(or-hydroxybenzyl)pyrazolo[1,5-a]pyridines with trifluoroacetic acid in dichloromethane resulted in the formation of pyrazolo[1,5-a]pyridines, bis[α-(pyrazolo[1,5-a]pyrid-3-yl)benzyl] ethers, and phenylbis(pyrazolo[1,5-a]pyrid-3-yl)methanes, depending upon the presence or absence of the substituents at the 2- and/or 4-positions and the reaction conditions employed. 相似文献