共查询到20条相似文献,搜索用时 23 毫秒
1.
以7-甲氧基-1-萘满酮为原料,经Wittig反应、去甲基化、烯醇互变和Jones氧化反应等制得关键中间体7-甲氧基-1,2,3,4-四氢化萘-1-羧酸(4); 4-异丙基苯胺和4-(二甲基胺基)苯甲醛经过还原胺化反应得(E)-4-{[(4-异丙基苯基)亚胺基]甲基}-N,N-二甲基苯胺(6); 4转化为相应的酰氯后与6反应合成N-[4-(二甲基氨基)苄基]-N-(4-异丙基苯基)-7-甲氧基-1,2,3,4-四氢化萘-1-甲酰胺(W-54011),总收率24%,其结构经1H NMR, 13C NMR和HR-MS(ESI)表征。
相似文献
2.
WANG Yong-Jinga b ZHANG Han-Huia b① HUANG Chang-Canga b YU Xiao-Honga SUN Qiao-Zhena SUN Rui-Qinga a 《结构化学》2005,24(6):651-654
1 INTRODUCTION Great efforts have been made for the discovery of microporous solids due to their rich structural chemi- stry and wide applications in some commercial pur- poses as ion exchanger, absorbent, and catalyst[1]. Since many properties of porous materials depend on their composition and architecture, recent attention has been paid to incorporating other main group and tra- nsition metals into open frameworks, and plenty of materials are reported to contain polyhedra, such as [X… 相似文献
3.
《Tetrahedron: Asymmetry》1998,9(16):2947-2960
Whereas deoxyrhamnojirimycin (LRJ) 1 shows no significant inhibition of naringinase (an α-l-rhamnosidase), its C-5 epimer 2 is a potent and specific inhibitor of the enzyme and demonstrates the value of unambiguous chemical synthesis of such materials in the evaluation of their biological properties. In contrast, moderately weak inhibition towards an α-d-mannosidase is shown by both deoxymannojirimycin (DMJ) 5 and its C-5 epimer 6. Mimics of l-rhamnose which are recognised by enzymes that synthesise or process l-rhamnose may inhibit either the biosynthesis of the sugar or its incorporation into mycobacterial cell walls, providing new strategies for the treatment of diseases such as tuberculosis and leprosy. Molecular modelling studies provide a rationale for the surprisingly potent activity of the C-5 epimer 2 compared with LRJ 1 and support a general hypothesis that potent piperidine glycosidase inhibitors mimic the 4H3 conformation of the relevant glycopyranosyl cation intermediate. 相似文献
4.
Vanessa Montoya Jordi García-Antón Mercè Font-Bardia 《Journal of fluorine chemistry》2007,128(9):1007-1011
The reaction of the β-diketone 4,4,4-trifluoro-1-pyridin-2-yl-butane-1,3-dione and the monosubstituted hydrazine 2-hydroxyethylhydrazine has been investigated. Two products have been identified, 2-(2-hydroxyethyl)-3-pyridin-2-yl-5-trifluoromethyl-4,5-dihydropyrazole (P) and 2-(3-pyridin-2-yl-5-trifluoromethylpyrazol-1-yl)ethanol (L) in proportion 2:8, when the reaction was done at room temperature in ethanol for 15 h. The preparation of P as a pure product was performed in ethanol at 0 °C for 7 h. P has been characterized by 1H, 13C{1H} and 19F{1H} NMR spectroscopy and by other techniques as appropriate. 相似文献
5.
6.
Photoluminescence (PL) of a heterocomposite, consisting of the nematic liquid crystal (LC) 4-pentyl-4´-cyanobiphenyl (5CB) and anisometric nanoparticles of montmorillonite (MMT) clay, modified by cetyltrimethylammonium bromide (CTAB) has been investigated at 4.2 and 300 K. The incorporation of this organoclay (B4) to 5CB decreases the emission intensity by 7–8 times due to efficient resonant quenching of the exciting energy by the organoclay. The spectrum shifts to a long-wave region, with this effect being considerably larger at low temperatures. Graphical separation of complex bands, corresponding to the bulk 5CB and 5СВ?+?В4 heterosystem at both temperatures revealed that the presence of the organoclay resulted in a significant growth of LC dimer quantity, shifting spectra towards longer wavelengths. Changes in the 5CB luminescence under organoclay influence can be explained by quite strong interphase interactions specified earlier by infrared spectroscopy between the MMT surface and LC, and by a realisation of more flat conformations of 5CB molecules. Confinement effects prevent full crystallisation of 5CB in the 5CB?+?B4 composite, and LC dimer structures located in the organoclay near-surface layers on the outer surface of the nanoparticles and inside its galleries remain in a larger amount, at low temperature, when compared to bulk 5CB. The remaining LC crystallises and photoluminescence from the 5CB monomers becomes intense. 相似文献
7.
5-阿维菌素B1a酯的合成及生物活性 总被引:4,自引:0,他引:4
阿维菌素B1a(AVB1a)与羧酸在DMAP/DCC体系中直接酯化,得到10个5-AVB1a酯衍生物,产率50%~79%;其化学结构由IR,1H NMR,13CNMR和MS谱确证.生物活性测定结果表明,部分5-阿维菌素B1a酯衍生物具有良好的杀虫、杀螨活性. 相似文献
8.
Xiong KC Jiang FL Gai YL Yuan DQ Han D Ma J Zhang SQ Hong MC 《Chemistry (Weinheim an der Bergstrasse, Germany)》2012,18(18):5536-5540
Chlorine caged in! The chlorine-induced assembly of six shuttlecock-like tetranuclear Mn(II) building blocks generated in situ based on p-tert-butylthiacalix[4]arene and facial anions gave rise to a novel truncated distorted octahedral cationic coordination cage with a μ(5)-carbonato-bridged Mn(II)(24) core. 相似文献
9.
Kim Glootz Daniel Himmel Daniel Kratzert Burkhard Butschke Harald Scherer Ingo Krossing 《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2019,131(40):14300-14304
The reaction of the Ga+ source [Ga(PhF)2]+[Al(ORF)4]? with the neutral σ‐donor ligand dmap (4‐Me2N‐C6H4N) produces the unexpectedly large and fivefold positively charged cluster cation salt [Ga5(dmap)10]5+([Al(ORF)4]?)5. It includes a regular and planar Ga5 pentagon with strong metal–metal bonding. Additionally, the compound represents the first salt in which an ionic 1:5 packing is realized. We discuss the nature of this structure which results from the conversion of the non‐bonding 4s2 lone‐pair orbitals into fully Ga‐Ga‐bonding orbitals and the solid‐state arrangement of the ions constituting the lattice as an almost orthohexagonal AX5 lattice, possibly the aristotype of any 5:1 salt. 相似文献
10.
syn-5,5-Bis-5H-dibenzo[a,d]cyclohepten-5-ylidene (2syn), an overcrowded bistricyclic aromatic ene with central seven-membered rings, undergoes a thermal isomerization to the anti stereoisomer (2anti) at elevated temperatures, with G
inv
(174°C)=36.4 kcal/mole. The high-energy barrier for syn anti isomerization of2 is compared with the corresponding inversion barrier of 5H-dibenzo[a,d]cycloheptene derivatives and interpreted in terms of a lower degree of overcrowding in2 relative to bistricyclic enes (1) with central five- and six-membered rings. The overcrowding features of2syn,2anti, and theiranti-10,11,10,11-tetrahydro derivative (3) is analyzed, and a mechanism for the syn anti isomerization of 2 is proposed. 相似文献
11.
12.
Xu Qing-Feng Lang Jian-Ping Wei Qiao-Hua Chen Zhong-Ning 《Transition Metal Chemistry》2004,29(5):483-487
A novel heterobimetallic sulfide cluster [(
5-C5Me5)WS3Au(dppms)][dppms = bis(diphenylphosphino)methane monosulfide] was prepared by the reaction of [PPh4][(
5-C5Me5)WS3] with AuI and dppm [dppm = bis(diphenylphosphino)methane] in MeCN. The title compound was fully characterized by elemental analysis, i.r., u.v.–vis., 1H-n.m.r. spectra, and by single crystal X-ray crystallography. In the molecular structure, the Au atom is trigonally coordinated by two bridging S atoms of a [(
5-C5Me5)WS3]– anion and a P atom of the dppms molecule. The formation mechanism for this compound is discussed. 相似文献
13.
LIAOLian-an FANGHong-yun LIZheng-ming FANZhi-jin 《高等学校化学研究》2004,20(5):551-557
Fourteen new derivatives of avermectin B1a, and ivermectin B1a were synthesized from C5-O-triphenyl silylavermectin B1a and ivermectin B1a (yield from 40% to 83%). Their chemical structures were characterized by means of IR. ^1H NMR, ^13C NMR and FAB-MS spectrometries. Some of them show excellent insecticidal activity. 相似文献
14.
Background
Like all tripartite motif (TRIM) proteins, the retroviral restriction factor TRIM5α consists of RING, B-box 2 and coiled-coil domains, with a C-terminal B30.2(SPRY) domain. Although structures have been determined for some individual TRIM domains, the structure of an intact TRIM protein is unknown. 相似文献15.
SpirobenzopyranderivativesarewellknownphotochroAncorganiccompounds,whichcanbereversiblyisomerizedbyUVandvisiblelightirradiation.Whencrownmoietiesareincorporatedtothespirobenzopyrans,theymayprovidespirobenzopyranderivativeswithspecificcationbindingabilities,whichcaninduceisomerizationofthespirobenzopyrans,thusdrasticallyaffectingtheisomerizationequilibriumbetweenthespiropyranandthemerocycanineforms.Thesecrownedspirobenzopyranderivativesaremoreeffectiveforphotochemicalcontrolofphysicalpropertie… 相似文献
16.
N. A. Talzhanov V. I. Yamovoi A. T. Kulyyasov K. M. Turdybekov S. M. Adekenov 《Chemistry of Natural Compounds》2004,40(2):129-133
A new sesquiterpene lactone 5(H)-austricin was isolated from white wormwood (Artemisia leucodes Schrenk.). Its structure was established by chemical and spectral methods. 相似文献
17.
Arlette Solladié-Cavallo Khalid Azyat Loïc Jierry Dominique Cahard 《Journal of fluorine chemistry》2006,127(11):1510-1514
A new tetrasubstituted cyclohexanone 5 fluorinated at C2 and having a fluoroisopropyl group at C5 has been synthesized in five steps from 3-methyl cyclohexenone and the structure of both diastereomers fully assigned. It is shown that diastereomer Ia having the fluorine atom at C2 in the axial position (in the most populated conformer of this diastereomer) is major and is a good catalyst for epoxidation of trans-olefins by oxone while diastereomer IIe is not. Moreover, only 0.3 equiv. of 5-Ia are necessary and the ketone is totaly recovered after reaction (no Baeyer-Villiger). 相似文献
18.
Krow GR Liu N Sender M Lin G Centafont R Sonnet PE DeBrosse C Ross CW Carroll PJ Shoulders MD Raines RT 《Organic letters》2010,12(23):5438-5441
CD spectra for homooligomers (n = 4, 6, 8) of (1S,4R,5R)-5-syn-carboxy-2-azabicyclo[2.1.1]hexane (MPCA), a methano-bridged pyrrolidine β-carboxylic acid, suggest an ordered secondary structure. Even in the absence of internal hydrogen bonding, solution NMR, X-ray, and in silico analyses of the tetramer are indicative of conformations with trans-amides and C(5)-amide-carbonyls oriented toward the C(4) bridgehead. This highly constrained β-amino acid could prove useful in the ongoing development of well-defined foldamers. 相似文献
19.
20.
The specific forms of folic acid, a vitamin of the B-group, are generally determined in foods after sample clean-up using
affinity columns containing folate binding protein covalently bound to a solid support material. The new approach described
in the present paper is to isolate the target analyte by using the less costly milk protein β-lactoglobulin, entrapped in
the pores of a sol-gel glass. Sol-gel β-lactoglobulin columns were included in a clean-up procedure developed to determine
5-methyl-tetrahydrofolate in milk samples. Concentrations of 5-methyl-tetrahydrofolate in milk samples with different fat
contents ranged from 31 to 70 ng/ml. Repeated use of the β-lactoglobulin columns for sample preparation resulted in a decrease
of analyte recovery. However, due to the high column to column reproducibility good results were obtained when the standard
addition method was performed with columns which had already been used for the same number of sample clean-ups. 相似文献