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1.
The syntheses of (±)-curcuphenol 1, (±)-curcudiol 2, (±)-curcuhydroquinone 3, and (±)-curcuquinone 4 have been achieved. The key steps involved in the syntheses were the Reformatsky reaction and hydrogenation reaction. 相似文献
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对四种天然二聚二苯乙烯类化合物Shegansu B (1), Gnetuhainin F (1a), Maackin A (2)以及Cassigarol E (3)的全合成进行了研究. 以3,5-二羟基苯甲酸(4)为起始原料, 经六步反应制得异丹叶大黄素(13)和白皮杉醇(14), 在HRP/H2O2酶催化氧化体系中, 13和14分别进行自身的氧化偶联得到各自的二聚产物. 首次完成了1a, (±)-2和(±)-3的全合成, 并以较文献报道为高的氧化偶联产率合成了(±)-1. 相似文献
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Photochemical cyclization of 3 afforded 5, 4 and 8.5 on LAH reduction furnished (±)-glaucine (6) and on treatment with ethanolic HCl afforded (±)-norglaucine (7). 10 obtained by the photocyclization of 9 was converted into 7 and 11 via 12. 相似文献
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Aporphines, (±)-thaliporphine (1). (±)-N-methyllaurotetatine (2), and (±)-isoboldine (3) were synthesised using photochemical cyclization as the key step. 相似文献
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Annulation: The efficient synthesis of 3-hydroxyalkyl isoquinolones and 6-hydroxyalkyl 2-pyridones is enabled through the intramolecular annulation of alkyne-tethered hydroxamic esters (see scheme, Cp*=pentamethylcyclopentadienyl). The reaction features high regioselectivity, broad substrate scope, and excellent functional-group tolerance, proceeds under mild reaction conditions with low catalyst loading, and obviates the need for an external oxidant. 相似文献
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An expeditious total synthesis of (±)-sempervirol (7) (±)-sugiol (8), and (±)-xanthopherol methyl ether (9) by extension of a simple general route is described. The stereochemical results of the cyclialkylation of 2-(2-p) and (2-m-isopropylphenylethyl)-1,3,3-trimethylcyclohexanols (1e) and (1f) follow the general pattern observed earlier. 相似文献
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A total synthesis of (±)-boschnialactone ( 1 ) and (±)-tertahydroanhydrodesoxyaucubigenin ( 2 ) is described and trisubstitued cyclopentenoid 3 is a key intermediate. 相似文献
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Chen ZH Zhang YQ Chen ZM Tu YQ Zhang FM 《Chemical communications (Cambridge, England)》2011,47(6):1836-1838
The first total synthesis of polycyclic Stemona alkaloid maistemonine has been achieved. The efficient approach features a stereoselective intramolecular Schmidt reaction, a ketone-ester condensation, and a Reformatsky reaction. Additionally, another Stemona alkaloid stemonamide was divergently synthesized from a common intermediate. 相似文献
10.
Collective syntheses of five spiro[4.5]decane framework bearing sesquiterpenoids, namely, α & β-vetispirenes, β-vetivone, agarospirol and hinesol as well as formal synthesis of axenol and gleenol from a readily available precursor cyclohexanone-β-ketoester via the intermediacy of a versatile intermediate (2,10-dimethylspiro[4.5]dec-1-en-6-one) have been accomplished in a concise manner. 相似文献
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《合成化学》2015,(6)
以取代苯乙酮和5-醛基-8-甲氧甲氧基-2-甲基-2-(4'-甲基-3'-戊烯基)-二氢-1-苯并吡喃为原料,经羟醛缩合反应制得两个中间体——7,2',4'-三甲氧甲氧基-6'-羟基-2-甲基-2-(4'-甲基-3'-戊烯基)-二氢-1-苯并吡喃查尔酮(3a)和7,2',4'-三甲氧甲氧基-5'-异戊烯基-6'-羟基-2-甲基-2-(4'-甲基-3'-戊烯基)-二氢-1-苯并吡喃查尔酮(3b);3a经环合和脱保护基反应合成了(±)-Malaysianone A(4a),产率12.9%;3b经脱保护基和环合反应合成了(±)-Tanariflavanones B(4b),产率5.2%。4a和4b的结构经1H NMR,13C NMR和HR-ESI-MS确证。 相似文献
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Total syntheses of (±)-securinine and (±)-allosecurinine that employ a tandem rhodium carbenoid-initiated Claisen/α-ketol rearrangement sequence as a key step are described. 相似文献
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《中国化学快报》1997,(11)
Eversinceβ-vetivoneanditscongenerswererecognizedtohavespiro[4,5]decaneratherthanthehydroazuleneskeleton,[1]themembersofthisclasshavebecomeafavoritetargetforsynthesis.Herein.weshowafacileconversionofthemajorphotoproductformedinthereactionofmethyl2,4-dioxopentancate(1)with1,5-dimethyl-6-methylenecyclochexene(2)[2]intovetispiranederivatives,hinesol(3),ametaboliteofAtractylodeslancea[3,4],andagarospirol(4)foundinAquilariaagollocha,[5]inracemicforms,respectively.WhenanEtoAsolutionof1and2wasintema… 相似文献
17.
《Tetrahedron: Asymmetry》1999,10(10):1969-1977
Pseudomonas cepacia lipase (PSL) efficiently catalyses the kinetic resolution of (±)-cis- and (±)-trans-1-aminoindan-2-ol through the O-acylation reaction of the corresponding N-benzyloxycarbonyl derivative using vinyl acetate as the acyl donor. In a similar way, cis-N-Cbz-2-aminoindan-1-ol is resolved when isopropenyl acetate is used as the acylating agent. The enantioselectivity of the reaction was lower for (±)-trans-N-Cbz-2-aminoindan-1-ol due to the different steric requirements for the two conformers of this substrate. 相似文献
18.
Novel routes to the naturally occurring indole alkaloid cycloclavine and its unnatural C(5)-epimer are described. Key features include the rapid construction of the heterocyclic core segments by two Diels-Alder reactions. An indole annulation was accomplished by a late-stage intramolecular Diels-Alder furan cycloaddition, and a methylenecyclopropane dienophile was used for a stereoselective intramolecular [4 + 2] cycloaddition to give the cyclopropa[c]indoline building block present in cycloclavine. 相似文献
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Cycloaltilisin 7是从桑科植物面包树(Artocarpus altilis)的芽中分离出的一种新异戊烯基黄烷酮,具有组织蛋白酶K抑制活性;Poinsettifolin B也是从桑科琉桑属植物Dorstenia poinsettifolia中分离出的一种新的香叶基查尔酮,Dorstenia poinsettifolia是原产于喀麦隆潮湿森林的草本植物,用于民间雅司病和伤口感染的治疗,对治疗皮肤病也有潜在功效.以廉价的羟苯乙酮和羟苯甲醛为原料,用简单温和的方法完成了这两种天然产物的首次全合成.所有新化合物的结构都经过HRMS,1H NMR和13C NMR的确认. 相似文献