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A convenient route with high stereo control to γ‐acetoxy dienoates is provided by the reaction of methyl propiolate with aldehydes in the presence of ZnEt2 and N‐methylimidazole at room temperature, followed by the catalytic conversion of the resulting γ‐hydroxy‐α,β‐acetylenic esters with p‐N,N‐dimethylaminopyridine (DMAP) in acetic anhydride (see scheme).
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Ahmed M. Ali Scott D. Taylor Prof. Dr. 《Angewandte Chemie (International ed. in English)》2009,48(11):2024-2026
Double protection : Efficient Fmoc‐based solid‐phase synthesis (SPPS) of sulfotyrosine (sY) peptides is achieved by incorporating the sY residue(s) as a dichlorovinyl‐protected (DCV) sulfodiester(s) and using 2‐methylpiperidine for Fmoc removal. After removal of the other protecting groups, the DCV group could be cleaved by mild hydrogenolysis giving the sY peptides in good yield.
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Sebastian Meier Dr. Andrew J. Benie Dr. Jens Ø. Duus Prof. Ole W. Sørensen Prof. 《Chemphyschem》2009,10(6):893-895
NMR artifact purging: Modern NMR experiments depend on efficient coherence transfer pathways for their sensitivity and on suppression of undesired pathways leading to artifacts for their spectral clarity. A novel robust adiabatic element suppresses hard‐to‐get‐at artifacts (see picture).
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Bingjun Xu Xiaoying Liu Jan Haubrich Dr. Robert J. Madix Prof. Cynthia M. Friend Prof. 《Angewandte Chemie (International ed. in English)》2009,48(23):4206-4209
The Midas touch : The low‐temperature transformation of methanol to methyl formate, formaldehyde, and formic acid is promoted by atomic oxygen adsorbed on metallic gold (see picture). The reactions occur with O‐containing Au nanoparticles formed on Au(111) upon oxidation with ozone at 200 K; the facile esterification to methyl formate occurs well below room temperature.
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Jianhui Zhu Yongmei Zhao Dr. Yanyan Zhu Ziyi Wu Miaoxin Lin Weijiang He Dr. Yan Wang Dr. Guangju Chen Prof. Dr. Lei Dong Dr. Junfeng Zhang Prof. Dr. Yi Lu Prof. Dr. Zijian Guo Prof. Dr. 《Chemistry (Weinheim an der Bergstrasse, Germany)》2009,15(21):5245-5253
The center of it all : An antitumor‐active trinuclear platinum complex forms unprecedented interstrand cross‐linked triadducts with 18‐mer DNA duplexes (see figure; complex in yellow with the platinum centers in red) and behaves differently from its dinuclear analogue.
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Thomas K. Wood Warren E. Piers Brian A. Keay Masood Parvez 《Angewandte Chemie (International ed. in English)》2009,48(22):4009-4012
2009: A boraanthracene odyssey : General routes to boraanthracene derivatives—long proposed, but never observed—are disclosed, along with the structural and photophysical properties of these compounds and their remarkable reactivity towards oxygen.
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Serpil Boz Meike Stöhr Dr. Umut Soydaner Marcel Mayor Prof. 《Angewandte Chemie (International ed. in English)》2009,48(17):3179-3183
Like pearls on a string , molecular building blocks have been preorganized and then interlinked on a surface (see STM images). In this way both the supramolecular self‐assembly of the reactants as well as the subsequent thermal activation to release the protecting group are controlled.
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