Alkaloids of the epigeal part ofAconitum karakolicum structure of karasamine and of 1-benzoylkarasamine

The known alkaloids phenyl--naphthylamine, karakoline, neoline, delsosine, monticamine, songorine, napelline acetylnapelline, napelline-n-oxide, and isoboldine and two new alkaloids, which have been called karasamine (I) and 1-benzoylkarasamine (II), have been isolated from the epigeal part ofAconitum karakolicum Rapaics. The structure of the new alkaloids have been shown by the preparation of the mono- and triacetates (IV) and (VI) of karasamine and its carbinolamine derivative (V), and also by the direct passage from karakoline (III) to karasamine (I) and 1-bezoylkarasamine (II) and by a study of their spectral characteristics.Institute of the Chemistry of Plant Substances, Academy of Sciences of the Uzbek SSR, Tashkent. Translated from Khimiya Prirodnykh Soedinenii, No. 2, pp. 207–210, March–April, 1986.     

The structure of karakoline

Summary We have isolated from the tubers ofAconitum karakolicum collected in the Kirghiz SSR, Kungei Alatau range, songorine, napelline, a base with mp 159–160°C, and the new alkaloids karakoline and a base with mp 222–224°C.The results of a study of the chemical reactions and spectral characteristics of karakoline have shown that it consists of a lycoctonine skeleton with N-ethyl and C₄-methyl groups, hydroxyls at C₁, C₈, and C₁₀ and a methoxy group at C₁₅.Institute of the Chemistry of Plant Substances, Academy of Sciences of the Uzbek SSR. Translated from Khimiya Prirodnykh Soedinenii, No. 2, pp. 199–205, March–April, 1973.     

The polybuffer separation of the alkaloids of Vinca erecta

Summary By separating the total alkaloids ofV.erecta according to their basicities in an APS, in addition to bases known previously we have isolated ervincidine, apovincamine, (+)-quebrachamine, dl-eburnamine, (–)-1,2-dehydroaspidospermidine, and kopsanone. This is the first time that these alkaloids have been obtained from this plant. Thin-layer chromatography showed the presence of another 10–12 uncharacterized alkaloids.The region of the passage into the buffer solutions of some alkaloids has also been established.Institute of the Chemistry of Plant Substances, Academy of Sciences of the Uzbek SSR. Translated from Khimiya Prirodnykh Soedinenii, No. 6, pp. 713–717, November–December, 1970.     

Alkaloids ofColchicum luteum

The paper gives a review of the alkaloids ofColchium luteum Baker from various growth sites. The structure of luteidine — one of the main alkaloids of the plant — has been established. In addition, two new alkaloids have been isolated from the plant and the structure of one of them has been established as collutine N-oxide.M. I Kalinin Turkmen Agricultural Institute, Ashkhabad, and V. I. Lenin Tashkent State University. Translated from Khimiya Prirodnykh Soedinenii, No. 6, pp. 810–815, November–December, 1985.     

2,10-Didemethylcolchicine — A new alkaloid from Merendera robusta

The alkaloid complex ofMerendera robusta Bge. (familyLiliaceae) growing in the Tashkent province of the Uzbek SSR has been investigated. The main alkaloids of this plant are colchicine and colchamine. Eleven tropolone alkaloids and their photochemical isomers have been isolated and identified. A new alkaloid of phenolic nature has been isolated for which the structure of 2,10-didemethylcolchicine has been established.V. I. Lenin Tashkent State University. Translated from Khimiya Prirodnykh Soedinenii, No. 1, pp. 67–71, January–February, 1991.     

Berberis alkaloids. XV. Structure of bargustanine

Bargustanine (I), belonging to a new type of isoquinoline alkaloids, has been isolated from the phenolic fraction of the total alkaloids from the roots ofBerberis vulgaris L. Its structure has been established by chemical and spectral methods.Institute of Chemistry of Plant Substances, Uzbekistan Republic Academy of Sciences, Tashkent. Andizhan State Medical Institute. Translated from Khimiya Prirodnykh Soedinenii, No. 1, pp. 44–47, January–February, 1993.     

Berberis alkaloids. XVII. Investigation of the alkaloids of Berberis heteropoda

The alkaloid composition of young shoots and leaves ofBerberis heteropoda Schrenk has been studied. In addition to known alkaloids, two new ones have been isolated — N-methyldihydroberberine and 8-oxoberberrubine, the structures of which were established by chemical transformations and a study of spectral properties. Of known alkaloids, berbamunine, aromoline, glaucine, thalicmidine, isocorydine, and reticuline have been found in this plant for the first time. Pseudopalmitine and laudanosine have been found for the first time in plants of the genusBerberis.Andizhan State Medical Institute. Institute of the Chemistry of Plant Substances of Uzbek Republic Academy of Sciences, Tashkent. Translated from Khimiya Prirodnykh Soedinenii, No. 1, pp. 53–59, January–February, 1993.     

Alkaloids of Papaver fugax

Papaver fugax growing on the shore of Lake Kazenoi Am in the Checheno-Ingushskii ASSR at the boundary with the Dagestan ASSR has yielded 0.39% of alkaloids. Seven alkaloids have been isolated, of which cheilanthifoline, scoulerine, and reticuline have been detected in this species for the first time, while it is the first time that d-remeroline has been found in a plant of thePapaver genus.Pyatigorsk Pharmaceutical Institute. Institute of the Chemistry of Plant Substances, Academy of Sciences of the Uzbek SSR, Tashkent. Translated from Khimiya Prirodnykh Soedinenii, No. 4, pp. 559–562, July–August, 1988.     

Alkaloids of Rauwolfia species growing in Vietnam

Reserpine, ajmaline, serpentine, ajmalicine, isoreserpiline, and other alkaloids have been isolated from the roots ofRauwolfia cambodiana Pierre ex Pitard,R. verticillata Baill. andR. serpentina Benth.R. vomitoria Afz. was the richest in alkaloids.Leningrad Institute of Pharmaceutical Chemistry. Translated from Khimiya Prirodnykh Soedinenii, No. 6, pp. 813–816, November–December, 1991.     

Foliosidine acetonide

Summary Foliosidine acetonide has been isolated from the mixture of alkaloids fromH. foliosum.Institute of the Chemistry of Plant Substances, Academy of Sciences of the Uzbek SSR. Translated from Khimiya Prirodnykh Soedinenii, No. 6, pp. 724–727, November–December, 1970.     

The separation of the alkaloids of Anabasis aphylla

Summary 1. The optimum conditions for the extraction of the high-boiling alkaloids from technical anabasine sulfate by dilution with water and at various pH values of the medium have been established.2. A method for removing anabasine and lupinine from a mixture of the high-boiling alkaloids ofAnabasis aphylla has been developed which is based on the formation of the carbonates of the strong bases.V. I. Lenin Tashkent State University. Dzerzhinskii Chimkent Pharmaceutical Chemicals Factory. Translated from Khimiya Prirodnykh Soedinenii, No. 4, pp. 468–472, July–August, 1974.     

N-oxides of homoaporphine alkaloids from Merendera raddeana

The alkaloid complex of the leaves, stems, seeds, and seed pods ofMerendera raddeana Rgl. (familyLiliaceae) has been investigated. A number of known tropolone alkaloids and their photochemical isomers have been isolated together with the homoaporphine bases merenderine, kreysiginine, and O-methyl-kreysiginine and their N-oxides, which have not been described in the literature. One of them (merenderine N-oxide) has been characterized by its physical constants and has been investigated by IR, PMR, and mass-spectral methods. By a study of the PMR spectrum of the fraction of neutral alkaloids from the leaves of the plant it has been established that it consists mainly of a mixture of equal amounts of colchicine and cornigerine.V. I. Lenin Tashkent State University. Translated from Khimiya Prirodnykh Soedinenii, No. 1, pp. 86–91, January–February, 1991.     

Alkaloids of Aconitum coreanum. III. 13-Acetyl-14-hydroxy-2-isobutyrylhetisine N-oxide

It has been established by the x-ray structural method that a new alkaloid isolated from the epigeal part ofAconitum coreanum has the structure of 13-acetyl-14-hydroxy-2-isobutyrylhetisine N-oxide. This is the first time that a N-oxide has been isolated among the hetisine alkaloids.Institute of the Chemistry of Plant Substances, Uzbek SSR Academy of Sciences, Tashkent. Translated from Khimiya Prirodnykh Soedinenii, No. 3, pp. 378–383, May–June, 1990.     

Alkaloids of Oxytropis. I

From the epigeal parts of two species ofOxytropis growing in Mongolia we have isolated the new alkaloids (+)-N-benzoyl-2-hydroxy-2-phenylethylamine and (–)-N-nicotinoyl-2-hydroxy-2-phenylethylamine, and also N-benzoyl-2-phenylethylamine, this being the first time this substance has been found in nature. The structures of the alkaloids were established on the basis of a comparative analysis of their spectral characteristics. Features of the mass-spectrometric behavior of this compound have been studied.Institute of Chemistry, Academy of Sciences of the Mongolian Peoples' Republic. Institute of Chemistry of Plant Substances, Uzbekistan Academy of Sciences, Tashkent. Translated from Khimiya Prirodnykh Soedinenii, Nos. 3,4, pp. 388–393, May–August, 1992.     

Diterpenoid alkaloids as a new class of antiarrhythmic agents. Structure-activity relationship

The cardiotropic activities of 111 diterpene alkaloids and their synthetic derivatives having lycoctine, heteratisine, napelline, and denudatine skeletons have been studied. It has been established that the overwhelming majority of these compounds exhibit a pronounced antiarrhythmic and antifibrillatory action, which is a finding of practical interest. Their structure-activity relationships — the directions of their action in relation to the results of x-ray structural analysis — have been investigated. The following have been selected and proposed as antiarrhythmic agents for practical medicine: lappaconitine, deacetyllappaconitine, 6-benzoylheteratisine, 14-benzoyl talatisamine, 1-benzoylnapelline, and others. Of them, lappaconitine hydrobromide (allapinin) has been introduced into public health practice.Institute of the Chemistry of Plant Substances, Academy of Sciences of the Republic of Uzbekistan, Tashkent, fax (3712) 40 64 75. Translated from Khimiya Prirodnykh Soedinenii, No. 2, pp. 254–270, March–April, 1997.     

Severine N-oxide and korsemine fromKorolkowia sewerzowii

Korsevine and the new alkaloids severine N-oxide and korsemine have been isolated from the combined alkaloids ofKorolkowia sewerzowii Regel. On the basis of the results of a study of the IR and NMR spectra of the alkaloids and also of a correlation with korseveriline and korsevine it has been established that base (I) is severine N-oxide and korsemine has the structure of korsevine 3-D-glucopyranoside.Institute of the Chemistry of Plant Substances, Academy of Sciences of the Uzbek SSR, Tashkent. Translated from Khimiya Prirodnykh Soedinenii, No. 6, pp. 823–826, November–December, 1979.     

Alkaloids ofAndrachne rotundifolia

Summary 1. The content of total alkaloids in the hypogeal parts ofAndrachne rotundifolia C. A. Mey. (family Euphorbicease) is 0.2–0.3% and in the epigeal parts 0.06–0.08%.The total alkaloids in both the hypogeal and the epigeal parts ofAndrachne rotundifolia consist of five or six non-phenolic bases.2. Three individual substances have been isolated: andrachnine C₁₁H₁₇NO₂, which is a new alkaloid; base (II), giving a perchlorate with mp 139°–140° C; and base (III) with mp 135°–136° C.Khimiya Prirodnykh Soedinenii, Vol. 2, No. 4, pp. 257–260, 1966     

Berberis alkaloids. XXII. Interbrinine and intebrimine — New alkaloids from Berberis integerrima

The known alkaloids reticuline, isoboldine, isocorydine, glaucine, armepavine, oxyacanthine, and heliamine and the new alkaloids intebrinine and intebrimine have been isolated from the total alkaloids of the leaves ofBerberis integerrima, and structures have been proposed for the latter two on the basis of spectral characteristics and independent synthesis.Andizhan State Medical Institute. Institute of the Chemistry of Plant Substances, Uzbekistan Republic Academy of Sciences, Tashkent. Translated from Khimiya Prirodnykh Soedeninii, No. 1, pp. 70–73, January–February, 1993.     

Extraction of the total alkaloids from the epigeal part of Aconitum orientale

The process of extracting the total alkaloids fromAconitum orientale with aqueous solutions of a number of electrolytes has been investigated. It has been established that it is most desirable to use 2% solutions of H₂SO₄ and 5% solutions of CH₃COOH. The optimum parameters of the process have been found, under which the degree of extraction of the total alkaloids averages 96%.I. G. Kutateladze Institute of Pharmacochemistry, Georgian Academy of Sciences. Translated from Khimiya Prirodnykh Soedinenii, No. 6, pp. 816–821, November–December, 1991.     

Umbrofine and 6-acetylumbrofine — New C18-diterpene alkaloids from Aconitum umbrosum

Two new alkaloids — umbrofine and 6-acetylumbrofine — have been isolated fromAconitum umbrosum, and their structures have been established on the basis of spectral characteristics.Institute of Chemistry of Plant Substances, Uzbekistan Republic Academy of Sciences, Tashkent. Translated from Khimiya Prirodnykh Soedenini, No. 1, pp. 73–77, January–February, 1993.