A microbial continuous culture system with diffusion and diversified growth

A reaction-diffusion model is presented to describe the microbial continuous culture with diversified growth. The existence of nonnegative solutions and attractors for the system is obtained, the stability of steady states and the steady state bifurcation are studied under three growth conditions. In the case of no growth inhibition or only product inhibition, the system admits one positive constant steady state which is stable; in the case of growth inhibition only by substrate, the system can have two positive constant steady states, explicit conditions of the stability and the steady state bifurcation are also determined. In addition, numerical simulations are given to exhibit the theoretical results.     

Stability analysis of diffusive predator-prey model with modified Leslie-Gower and Holling-type III schemes

The stability of a diffusive predator-prey model with modified Leslie-Gower and Holling-type III schemes is investigated. A threshold property of the local stability is obtained for a boundary steady state, and sufficient conditions of local stability and un-stability for the positive steady state are also obtained. Furthermore, the global asymptotic stability of these two steady states are discussed. Our results reveal the dynamics of this model system.     

Stability Analysis of Diffusive Predator-Prey Model with Modified Leslie-Gower and Holling-Type II Schemes

The stability of a diffusive predator-prey model with modified Leslie-Gower and Holling-type II schemes is investigated. A threshold property of the local stability is obtained for a boundary steady state, and sufficient conditions of local stability and un-stability for the positive steady state are also obtained. Furthermore, the global asymptotic stability of these two steady states are discussed. Our results reveal the dynamics of this model system.     

具有多重严重故障和非严重故障和修复功能的系统的可靠性分析

该文研究一个具有多重严重故障和非严重故障和修复功能的系统的可靠性问题. 在泛函分析理论的框架下,将系统方程组写成一个 Banach 空间中的抽象初值问题,利用算子半群方法,研究了该系统的适定性、稳态解的存在性以及稳定性.表明: 在系统模型的假定下,所研究的系统是适定的,存在非负动态解和稳态解, 特别在范数意义下动态解收敛到稳态解.从而由系统稳态解得到的系统指标是可靠的.     

Mathematical model of hematopoiesis dynamics with growth factor-dependent apoptosis and proliferation regulations

We consider a nonlinear mathematical model of hematopoietic stem cell dynamics, in which proliferation and apoptosis are controlled by growth factor concentrations. Cell proliferation is positively regulated, while apoptosis is negatively regulated. The resulting age-structured model is reduced to a system of three differential equations, with three independent delays, and existence of steady states is investigated. The stability of the trivial steady state, describing cells dying out with a saturation of growth factor concentrations is proven to be asymptotically stable when it is the only equilibrium. The stability analysis of the unique positive steady state allows the determination of a stability area, and shows that instability may occur through a Hopf bifurcation, mainly as a destabilization of the proliferative capacity control, when cell cycle durations are very short. Numerical simulations are carried out and result in a stability diagram that stresses the lead role of the introduction rate compared to the apoptosis rate in the system stability.     

A competition un-stirred chemostat model with virus in an aquatic system

A reaction–diffusion system of two bacteria species competing a single limiting nutrient with the consideration of virus infection is derived and analysed. Firstly, the well-posedness of the system, the existence of the trivial and semi-trivial steady states, and some prior estimations of the steady states are given. Secondly, a single species subsystem with virus is studied. The stability of the trivial and semi-trivial steady states and the uniform persistence of the subsystem are obtained. Further, taking the infective ability of virus as a bifurcation parameter, the global structure of the positive steady states and the effect of virus on the positive steady states are established via bifurcation theory and limiting arguments. It shows that the backward bifurcation may occur. Some sufficient conditions for the existence, uniqueness and stability of the positive steady state are also obtained. Finally, some sufficient conditions on the existence of the positive steady states for the full system are derived by using the fixed point index theory. Some results on persistence or extinction for the full system are also obtained.     

Mini-Maximizers for Reaction-Diffusion Systems with Skew-Gradient Structure

A reaction-diffusion system with skew-gradient structure is a sort of activator-inhibitor system that consists of two gradient systems coupled in a skew-symmetric way. Any steady state of such a system corresponds to a critical point of some functional. The aim of this paper is to study the relation between a stability property as a steady state of the reaction-diffusion system and a mini-maximizing property as a critical point of the functional. It is shown that a steady state of the skew-gradient system is stable regardless of time constants if and only if it is a mini-maximizer of the functional. It is also shown that the mini-maximizing property is closely related with the diffusion-induced instability. Moreover, by using the property that any mini-maximizer on a convex domain is spatially homogeneous, quite a general instability criterion is obtained for some activator-inhibitor systems. These results are applied to the diffusive FitzHugh-Nagumo system and the Gierer-Meinhardt system.     

Stability and bifurcations for the chronic state in Marchuk's model of an immune system

In the paper we present known and new results concerning stability and the Hopf bifurcation for the positive steady state describing a chronic disease in Marchuk's model of an immune system. We describe conditions guaranteeing local stability or instability of this state in a general case and for very strong immune system. We compare these results with the results known in the literature. We show that the positive steady state can be stable only for very specific parameter values. Stability analysis is illustrated by Mikhailov's hodographs and numerical simulations. Conditions for the Hopf bifurcation and stability of arising periodic orbit are also studied. These conditions are checked for arbitrary chosen realistic parameter values. Numerical examples of arising due to the Hopf bifurcation periodic solutions are presented.     

一类旋转磁对流系统振幅方程的双波前解的存在性和稳定性分析

研究了旋转磁对流系统的振幅方程的一类稳态解的存在性和稳定性问题,得出了振幅方程的双波前解的存在性定理及相容性条件,通过变分特征化方法证明了方程解的不稳定性.     

A note on a diffusive predator-prey model and its steady-state system

In this note, a diffusive predator-prey model subject to the homogeneous Neumann bound- ary condition is investigated and some qualitative analysis of solutions to this reaction-diffusion system and its corresponding steady-state problem is presented. In particular, by use of a Lyapunov function, the global stability of the constant positive steady state is discussed. For the associated steady state problem, a priori estimates for positive steady states are derived and some non-existence results for non-constant positive steady states are also established when one of the diffusion rates is large enough. Consequently, our results extend and complement the existing ones on this model.     

Analysis of stability and Hopf bifurcation for HIV-1 dynamics with PI and three intracellular delays

Mathematical model for the effects of protease inhibitor on the dynamics of HIV-1 infection model with three delays is proposed and analyzed. Some analytical results on the global stability of viral free steady state and infected steady state are obtained. The stability/instability of the positive steady state and associated Hopf bifurcation are investigated by analyzing the characteristic equations.     

A generalized Degn–Harrison reaction–diffusion system: Asymptotic stability and non-existence results

In this paper we study the Degn–Harrison system with a generalized reaction term. Once proved the global existence and boundedness of a unique solution, we address the asymptotic behavior of the system. The conditions for the global asymptotic stability of the steady state solution are derived using the appropriate techniques based on the eigen-analysis, the Poincaré–Bendixson theorem and the direct Lyapunov method. Numerical simulations are also shown to corroborate the asymptotic stability predictions.Moreover, we determine the constraints on the size of the reactor and the diffusion coefficient such that the system does not admit non-constant positive steady state solutions.     

Travelling waves of a delayed SIRS epidemic model with spatial diffusion

This paper is concerned with the existence of travelling waves to an SIRS epidemic model with bilinear incidence rate, spatial diffusion and time delay. By analysing the corresponding characteristic equations, the local stability of a disease-free steady state and an endemic steady state to this system under homogeneous Neumann boundary conditions is discussed. By using the cross iteration method and the Schauder’s fixed point theorem, we reduce the existence of travelling waves to the existence of a pair of upper-lower solutions. By constructing a pair of upper-lower solutions, we derive the existence of a travelling wave solution connecting the disease-free steady state and the endemic steady state. Numerical simulations are carried out to illustrate the main results.     

Asymptotic behavior and stability switch for a mature–immature model of cell differentiation

We consider a nonlinear age-structured model, inspired by hematopoiesis modelling, describing the dynamics of a cell population divided into mature and immature cells. Immature cells, that can be either proliferating or non-proliferating, differentiate in mature cells, that in turn control the immature cell population through a negative feedback. We reduce the system to two delay differential equations, and we investigate the asymptotic stability of the trivial and the positive steady states. By constructing a Lyapunov function, the trivial steady state is proven to be globally asymptotically stable when it is the only equilibrium of the system. The asymptotic stability of the positive steady state is related to a delay-dependent characteristic equation. Existence of a Hopf bifurcation and stability switch for the positive steady state is established. Numerical simulations illustrate the stability results.     

Global Stability of a Predator-Prey System with Stage Structure for the Predator

In this paper,some feasibly sufficient conditions are obtained for the global asymptotic stability of a positive steady state of a predator-prey system with stage structure for the predator by using the theory of competitive systems,compound matrices and stability of periodic orbits,and then the work of Wang [4] is improved.     

基于比率的广义Holling-Tanner系统的全局渐近稳定性

本文对基于比率的广义Holling-Tanner系统进行了定性分析,给出了系统解有界的条件和平衡点局部稳定的条件．通过构造适当的Liapunov函数,得到了正平衡点全局渐近稳定性的充分条件．     

Bifurcation from two equilibria of steady state solutions for non-reversible amplitude equations

In this paper, bifurcation and stability of two kinds of constant stationary solutions for non-reversible amplitude equations on a bounded domain with Neumann boundary conditions are investigated by using the perturbation theory and weak nonlinear analysis. The asymptotic behaviors and local properties of two explicit steady state solutions, and pitch-fork bifurcations are also obtained if the bounded domain is regarded as a parameter. In addition, the stability of a new increasing or decaying local steady state solution with oscillations are analyzed.     

一类捕食-食饵-互惠模型非常数正平衡解的存在性及分歧

讨论了一类捕食-食饵-互惠反应扩散系统的非常数正平衡解.首先分析了常数正平衡解的稳定性,其次;利用最大值原理和Harnack不等式给出了正解的失验估计.在此基础上,利用积分性质进一步讨论了非常数正解的不存在性,相应地证明了当扩散系数d_2 d_3大于特定正常数且扩散系数d_1有界时此模型没有非常数正解.同时利用度理论证明了当模型的线性化算子的正特征值的代数重数是奇数且扩散系数d_3不小于给定正常数时此模型至少存在一个非常数正解,最后研究了非常数正解的分歧.     

Bifurcation analysis of HIV infection model with antibody and cytotoxic T‐lymphocyte immune responses and Beddington–DeAngelis functional response

In this paper, a mathematical model for HIV‐1 infection with antibody, cytotoxic T‐lymphocyte immune responses and Beddington–DeAngelis functional response is investigated. The stability of the infection‐free and infected steady states is investigated. The basic reproduction number R₀ is identified for the proposed system. If R₀ < 1, then there is an infection‐free steady state, which is locally asymptotically stable. Further, the infected steady state is locally asymptotically stable for R₀ > 1 in the absence of immune response delay. We use Nyquist criterion to estimate the length of the delay for which stability continues to hold. Also the existence of the Hopf bifurcation is investigated by using immune response delay as a bifurcation parameter. Numerical simulations are presented to justify the analytical results. Copyright © 2014 John Wiley & Sons, Ltd.     

Dynamic properties of the oregonator model with delay

Delayed feedbacks are quite common in many&nbsp;physical and biological systems and in particular many physiological systems. Delay can cause a stable system to become unstable and vice versa. One of the well-studied non-biological chemical oscillators is the Belousov-Zhabotinsky(BZ) reaction. This paper presents an investigation of stability and Hopf bifurcation of the&nbsp;Oregonator model with delay. We analyze the stability of the equilibrium by using linear stability method. When the eigenvalues of the characteristic equation associated with the linear part are pure imaginary, we obtain the corresponding delay value. We find that stability of the steady state changes when the delay passes through the critical value. Then, we calculate the explicit formulae for determining the direction of the Hopf bifurcation and the stability of these periodic solutions bifurcating from the steady states, by using the normal form theory and the center manifold theorem. Finally, numerical simulations results are given to support the theoretical predictions by using Matlab and DDE-Biftool.