Properties of stability and Hopf bifurcation for a HIV infection model with time delay

In this paper, we consider the classical mathematical model with saturation response of the infection rate and time delay. By stability analysis we obtain sufficient conditions for the global stability of the infection-free steady state and the permanence of the infected steady state. Numerical simulations are carried out to explain the mathematical conclusions.     

Internalization and end flux in morphogen gradient formation

Two simple reaction–diffusion systems of partial differential equations and auxiliary conditions governing the activities of diffusible ligands such as Dpp in anterior–posterior axis of Drosophila wing imaginal discs were previously formulated and investigated by numerical simulations in [Developmental Cell 2 (2002) 785–796]. System B focuses on diffusion, reversible binding with receptors and ligand-mediated degradation for a fixed receptor concentration uniform in time and space. System C extended this basic but meaningful model to allow for endocytosis, exocytosis and receptor synthesis and degradation. The present paper provides a mathematical underpinning for the computational studies of these two systems and some insight gained from our analysis. We will see for instance that the two boundary value problems governing the steady state for the two systems are identical in form. This result will enable us to avoid dealing with internalization explicitly when we investigate other complex morphogen activities such as the effects of (1) feedback and (2) diffusible and non-diffusible molecules competing for ligands and receptors to inhibit cell signaling and pattern formation. The principal contribution of the present work pertains to the extension of System C to allow for a ligand flux at the source end. The more general model has many significant consequences including the removal of a limitation of previous models on ligand synthesis rate for the existence of steady state behavior. Linear stability of the corresponding steady state behavior is established. While the actual decay rate of transients is less accessible in this new model, it is possible to obtain tight upper and lower bounds for the decay rate in terms of the (effective) degradation rate of the receptors and that of the ligand-receptor complexes.     

Nonlinear Physiologically Structured Population Models with Two Internal Variables

First-order hyperbolic partial differential equations with two internal variables have been used to model biological and epidemiological problems with two physiological structures, such as chronological age and infection age in epidemic models, age and another physiological character (maturation, size, stage) in population models, and cell-age and molecular content (cyclin content, maturity level, plasmid copies, telomere length) in cell population models. In this paper, we study nonlinear double physiologically structured population models with two internal variables by applying integrated semigroup theory and non-densely defined operators. We consider first a semilinear model and then a nonlinear model, use the method of characteristic lines to find the resolvent of the infinitesimal generator and the variation of constant formula, apply Krasnoselskii’s fixed point theorem to obtain the existence of a steady state, and study the stability of the steady state by estimating the essential growth bound of the semigroup. Finally, we generalize the techniques to investigate a nonlinear age-size structured model with size-dependent growth rate.

     

A differential equation model of HIV infection of CD4T-cells with cure rate

A differential equation model of HIV infection of CD4⁺T-cells with cure rate is studied. We prove that if the basic reproduction number R₀<1, the HIV infection is cleared from the T-cell population and the disease dies out; if R₀>1, the HIV infection persists in the host. We find that the chronic disease steady state is globally asymptotically stable if R₀>1. Furthermore, we also obtain the conditions for which the system exists an orbitally asymptotically stable periodic solution. Numerical simulations are presented to illustrate the results.     

Steady states in a structured epidemic model with Wentzell boundary condition

We introduce a non-linear structured population model with diffusion in the state space. Individuals are structured with respect to a continuous variable which represents a pathogen load. The class of uninfected individuals constitutes a special compartment that carries mass; hence the model is equipped with generalized Wentzell (or dynamic) boundary conditions. Our model is intended to describe the spread of infection of a vertically transmitted disease, for e.g., Wolbachia in a mosquito population. Therefore, the (infinite dimensional) non-linearity arises in the recruitment term. First, we establish global existence of solutions and the principle of linearised stability for our model. Then, in our main result, we formulate simple conditions which guarantee the existence of non-trivial steady states of the model. Our method utilises an operator theoretic framework combined with a fixed-point approach. Finally in the last section, we establish a sufficient condition for the local asymptotic stability of the positive steady state.     

Stochastically perturbed vector-borne disease models with direct transmission

In this paper we study a stochastic epidemic model of vector-borne diseases with direct mode of transmission and its delay modification. More precisely, we extend the deterministic epidemic models by introducing random perturbations around the endemic equilibrium state. By using suitable Lyapunov functions and functionals, we obtain stability conditions for the considered models and study the effect of the delay on the stability of the endemic equilibrium. Finally, numerical simulations for the stochastic model of malaria disease transmission are presented to illustrate our mathematical findings.     

Equilibrium switching and mathematical properties of nonlinear interaction networks with concurrent antagonism and self-stimulation

Concurrent decision-making model (CDM) of interaction networks with more than two antagonistic components represents various biological systems, such as gene interaction, species competition and mental cognition. The CDM model assumes sigmoid kinetics where every component stimulates itself but concurrently represses the others. Here we prove generic mathematical properties (e.g., location and stability of steady states) of n-dimensional CDM with either symmetric or asymmetric reciprocal antagonism between components. Significant modifications in parameter values serve as biological regulators for inducing steady state switching by driving a temporal state to escape an undesirable equilibrium. Increasing the maximal growth rate and decreasing the decay rate can expand the basin of attraction of a steady state that contains the desired dominant component. Perpetually adding an external stimulus could shut down multi-stability of the system which increases the robustness of the system against stochastic noise. We further show that asymmetric interaction forming a repressilator-type network generates oscillatory behavior.     

The role of four regulatory hormones in controlling testicular function in a delay model

Our proposed mathematical model for the secretion in hypothalamus-pituitary-gonadal axis introduces four regulatory hormones viz. GnRH, FSH, Testosterone, and Inhibin. Here, we have considered four dimensional delay differential equations with multiple negative feedback loops which accounts for the pulsatile release of these hormones. We have derived the conditions for local asymptotic stability of the steady state and have estimated the length of delay to preserve the stability. Regions for stability and oscillations of the system are given in K − τ and m − τ plane, and the role of Inhibin in regulating the male fertility status by altering the FSH level has been clearly shown by computer simulation of the model.     

非线性感染率的HIV模型的动力学研究

众所周知,数学模型为引起人类免疫力缺乏的HIV-1型病毒和引起肝炎的HCV病毒的研究提供了重要信息.然而几乎所有的数学模型感染率都是线性的,而线性只是反映了T细胞与病毒分子之间的简单作用.这篇论文研究了一类具有非线性传染率的数学模型.通过分析我们得到了无病平衡态P0全局渐近稳定的条件及染病平衡态P-的稳定性条件.     

Dynamics of a spatiotemporal model on populations in a polluted river

In this paper, we investigate the dynamics for a reaction–diffusion–advection system which models populations in a polluted river. More precisely, we study the stability of steady states, which yields sufficient conditions that lead to population persistence or extinction. Furthermore, some dependence of the stability of the toxicant-only steady state and the population-toxicant coexistence steady state on the model parameters are given.     

Stability of an age-structured epidemiological model for hepatitis C

This article introduces an age-structured epidemiological model for the disease transmission dynamics of hepatitis C. We first show that the infection-free steady state is locally and globally asymptotically stable if the basic reproductive number ? ₀ is below one, in this case, the disease always dies out, then we prove that at least one endemic steady state exists when the reproductive number ? ₀ is above one, the stability conditions for the endemic steady states are also given.     

On the dynamics of a predator–prey model with nonconstant death rate and diffusion

The main goal of this paper is to describe the global dynamic of a predator–prey model with nonconstant death rate and diffusion. We obtain necessary and sufficient conditions under which the system is dissipative and permanent. We study the global stability of the nontrivial equilibrium, when it is unique. Finally, we show that there are no nontrivial steady state solutions for certain parameter configuration.     

Analysis of the dynamics of a delayed HIV pathogenesis model

In this paper, considering full Logistic proliferation of CD4⁺ T cells, we study an HIV pathogenesis model with antiretroviral therapy and HIV replication time. We first analyze the existence and stability of the equilibrium, and then investigate the effect of the time delay on the stability of the infected steady state. Sufficient conditions are given to ensure that the infected steady state is asymptotically stable for all delay. Furthermore, we apply the Nyquist criterion to estimate the length of delay for which stability continues to hold, and investigate the existence of Hopf bifurcation by using a delay τ as a bifurcation parameter. Finally, numerical simulations are presented to illustrate the main results.     

Diffusive logistic equation with constant yield harvesting, I: Steady States

We consider a reaction-diffusion equation which models the constant yield harvesting to a spatially heterogeneous population which satisfies a logistic growth. We prove the existence, uniqueness and stability of the maximal steady state solutions under certain conditions, and we also classify all steady state solutions under more restricted conditions. Exact global bifurcation diagrams are obtained in the latter case. Our method is a combination of comparison arguments and bifurcation theory.

     

Turing pattern of the Oregonator model

The Oregonator model is the mathematical dynamics which describes the Field-Körös-Noyes mechanics of the famous Belousov-Zhabotinskii? reaction. In this work, we establish some fundamental analytic properties of this dynamics and its corresponding steady state. Under various conditions on the parameters and the size of the reactor, we examine the existence and non-existence of non-constant steady states. In particular, for some properly chosen parameter ranges, we prove the occurrence of the Turing pattern generated by this Oregonator model. Our results exhibit interesting and very different roles of the diffusion rates and the reactor in the formation of the Turing pattern. Our mathematical analysis mainly relies on a priori estimates and the topological degree argument.     

Generalizing the Keller�CSegel Model: Lyapunov Functionals, Steady State Analysis, and Blow-Up Results for Multi-species Chemotaxis Models in?the?Presence of Attraction and Repulsion Between Competitive Interacting Species

In this paper we extend the famous Keller–Segel model for the chemotactic movement of motile species to some multi-species chemotaxis equations. The presented multi-species chemotaxis models are more general than those introduced so far and also include some interaction effects that have not been studied before. For example, we consider multi-species chemotaxis models with attraction and repulsion between interacting motile species. For some of the presented new models we give sufficient conditions for the existence of Lyapunov functionals. These new results are related to those of Wolansky (Scent and sensitivity: equilibria and stability of chemotactic systems in the absence of conflicts, preprint, 1998; Eur. J. Appl. Math. 13:641–661, 2002). Furthermore, a linear stability analysis is performed for uniform steady states, and results for the corresponding steady state problems are established. These include existence and nonexistence results for non-constant steady state solutions in some special cases.     

一类带有治愈率和ATL反应的HTLV-Ⅰ感染模型的性质分析

本文主要介绍一类带有治愈率和ATL反应的HTLV-Ⅰ感染且具有饱和传染率的模型的性质,通过稳定性分析,得到了被感染的T细胞绝灭和HTLV-Ⅰ感染持续的条件.     

Nonlinear Eigenvalue Problems in the Stability Analysis of Morphogen Gradients

This paper is concerned with several eigenvalue problems in the linear stability analysis of steady state morphogen gradients for several models of Drosophila wing imaginal discs including one not previously considered. These problems share several common difficulties including the following: (a) The steady state solution which appears in the coefficients of the relevant differential equations of the stability analysis is only known qualitatively and numerically. (b) Though the governing differential equations are linear, the eigenvalue parameter appears nonlinearly after reduction to a problem for one unknown. (c) The eigenvalues are determined not only as solutions of a homogeneous boundary value problem with homogeneous Dirichlet boundary conditions, but also by an alternative auxiliary condition to one of the Dirichlet conditions allowed by a boundary condition of the original problem. Regarding the stability of the steady state morphogen gradients, we prove that the eigenvalues must all be positive and hence the steady state morphogen gradients are asymptotically stable. The other principal finding is a novel result pertaining to the smallest (positive) eigenvalue that determines the slowest decay rate of transients and the time needed to reach steady state. Here we prove that the smallest eigenvalue does not come from the nonlinear Dirichlet eigenvalue problem but from the complementary auxiliary condition requiring only to find the smallest zero of a rational function. Keeping in mind that even the steady state solution needed for the stability analysis is only known numerically, not having to solve the nonlinear Dirichlet eigenvalue problem is both an attractive theoretical outcome and a significant computational simplification.     

The local bifurcation and stability of nontrivial steady states of a logistic type of chemotaxis

Chemotaxis is a type of oriented movement of cells in response to the concentration gradient of chemical substances in their environment. We consider local existence and stability of nontrivial steady states of a logistic type of chemotaxis. We carry out the bifurcation theory to obtain the local existence of the steady state and apply the expansion method on the chemotaxis to investigate the bifurcation direction. Moreover, by applying the bifurcation direction, we obtain the bifurcating steady state is stable when the bifurcation curve turns to right under certain conditions.