电化学免疫分析法研究进展

电化学免疫分析法是将免疫分析与电化学分析技术相结合的一种免疫分析新方法，近十多年来，电化免疫分析的研究有了迅速的发展。本文对电化学的免疫分析法的标记物、免疫方法、电化学检测技术进行了概括总结，并展望了电化学免疫分析的发展前景。     

药物免疫分析及其进展

本文对用于检测药物的免疫技术作了概述，并总结了近年来一些分析体系的改进和发展，同时指出了现代药物免疫分析的一些新的发展趋势，其中包括多分析物免疫分析方法，新型均相免疫分析方法，以及色谱、流动注射技术等在药物免疫分析中的应用。免疫分析技术可使今后药物定量检测更为灵敏，快速。     

某些滥用药物分析的进展

本文以滥用药物吗啡和可卡因的分析检测为例，对当前毒品分析的几种主要应用技术进行简要介绍。这些方法包括物理化学方法和免疫化学方法，侧重阐述滥用药物免疫分析法，强调了免疫分析技术在毒品分析中的特殊优越性。指出发展免疫分析化学研究是加强我国毒品检测能力的一条有效途径。     

毛细管电泳免疫分析的发展及动向

毛细管电泳免疫分析是一种新兴的免疫分析技术，较常规免疫分析方法具有很多的优越性。本文对毛细管电泳免疫分析近几年的发展情况作了总结，并对其发展的动向作了评述。     

《化学发光免疫分析》

化学发光免疫分析结合了化学发光的高灵敏度和免疫分析的高选择性，在临床检验、药物分析、环境检测等领域得到比较广泛的应用。全书分两部分：1-9章介绍化学发光免疫分析的新方法和基础理论研究；10-18章介绍化学发光免疫分析的应用和新进展，主要针对临床检测、环境分析以及食品安全的应用领域。第19章简要介绍了分析过程的质量管理与控制。     

免疫电化学发光

详细介绍了免疫电化学发光（ＩＥＣＬ）的基本原理和技术，评述了电化学发光在免疫分析中的应用，并进行了展望。     

红细胞标记抗体的电化学免疫分析

研究了红细胞标记抗体的电化学免疫分析法。用乙型肝炎单克隆抗体致敏的红细胞作双抗陕 心免疫分析的酶标二抗替代物。在免疫反应完成后，结合抗原－抗体免疫复合物上的敏化红细胞在低渗溶液中溶血，释放出血红蛋白。     

荧光纳米颗粒标记免疫分析*

荧光纳米颗粒标记是目前免疫分析研究中一个新兴的领域。由于荧光纳米颗粒标记可以有效地提高单个识别分子上标记的荧光量（F/P），从而大大提高分析的灵敏度。但是由于在标记和免疫分析过程中具有很多不同于传统荧光染料的特点，需要很多经验的积累，在现阶段限制了其在实际医学诊断中的广泛应用。本文就近年来荧光纳米颗粒标记免疫分析中涉及到的标记方法、免疫模式、影响因素等方面进行了综述。     

毒剂的生化分析技术

本文论述了酶法分析、核酸探针、免疫分析法特别是生物传感器在毒剂检测中的应用，提出了毒剂生化分析的发展方向。     

稀土螯合物探针及其在时间分辨荧光免疫分析中的应用

本文总结了近年来所用的稀土螯合物探针及其在时间分辨荧光免疫分析中的应用，着重介绍了稀土螯合物探针标记的原理和特点，评述了ＬＫＢ体系和ＣｙｂｅｒＦｌｕｏｒ体系的相对优缺点，展望了荧光免疫分析的发展趋势     

光谱法水质监测仪器和方法国内专利状况分析

水质动态数据可以为水环境可持续发展提供数据支撑,而水质监测仪器和方法的发展是获取准确水质数据和制定污染防治规划的关键. 目前光谱法水质监测仪器和方法相关专利的发展方向尚不明确. 基于万方数据知识服务平台的专利数据库,检索获得1993年至2022年在国内申请的光谱法水质监测相关仪器和方法的专利数据,对专利的申请情况、专利授权的仪器和方法所涉及的仪器类型、专利权申请主体及分布区域等方面进行比较分析,通过比较研究揭示当前国内光谱法水质监测仪器和方法的发展趋势,以期为政府、科研机构及企业相关人员制定光谱法水质监测仪器及方法的技术研发等提供决策依据.     

Development,validation, and implementation of capillary gel electrophoresis as a replacement for SDS‐PAGE for purity analysis of IgG2 mAbs

Capillary gel electrophoresis (CGE) methods with UV detection were developed for reduced and non‐reduced mAb analysis. These methods can be used to evaluate mAb purity, offering more reproducible quantitation compared with that of traditional SDS‐PAGE methods. These CGE methods have been utilized as platform technology for bioprocess development, formulation development, mAb characterization, drug substance/drug product release testing as well as a required methodology for stability testing. We have found these CGE methods to be applicable across a platform of mAbs in preclinical and clinical development, with the majority of mAbs requiring no modification to the method conditions. This methodology has been ICH validated and transferred to several supporting organizations. The data presented herein describes the development of CGE methodology, platform application to mAb purity analysis, ICH validation, reliability metrics, and considerations on technology enhancement for improved performance and throughput.     

Challenges in the relation between analysis and biotechnology

Analytical methods and systems for biotechnological applications are becoming increasingly important. The development of these methods and systems ask for an interdisciplinary approach. The use of analytical methods and systems in daily practice in biotechnological research, development, application and industrial production is essential for progress in biotechnology. Analytical methods and systems are not solely used for monitoring of research, development and production of biotechnological products but also goal in itself being used in many applications like medical, environmental, etc. This lecture presents an overview of current progress in Analytical Chemistry in relation to biotechnology. Special selected items have been treated into more detail.     

Stationary phase characterization and method development

The properties of stationary phases and their characterization methods are reviewed. New and significant developments have occurred in the last few years, and new methods for stationary phase characterization have become available. The characterization methods are discussed, and the differences between the different methods are pointed out. In addition, method development approaches are reviewed, with special emphasis on recent developments that employ multiple parameters in parallel. Also, the renewed interest of temperature as a tool in method development is surveyed.     

基于ZnO光阳极的染料敏化太阳电池的研究

本文全面介绍了基于ZnO光阳极的染料敏化太阳电池的研究和应用现状,特别是ZnO光阳极的制备方法,包括传统的手术刀法、丝网印刷技术和电沉积自组装方法,以及最近发展起来的机械挤压法、化学液相沉积法、化学气相沉积法和低温水热法等,对不同制备薄膜方法的工艺条件和优缺点进行了综述.同时介绍了微/纳米复合结构和直线电子传输对光电转换效率提高的作用.指出了ZnO太阳电池未来发展方向是:探索制备ZnO电极的新形貌和新方法,寻找性能更加优异的染料,以提高ZnO太阳电池的光电转换效率.     

Calorimetric monitoring of industrial chemical processes

Enthalpimetric methods used in chemical production and in process development are reviewed.On-line methods are applied to concentration analysis, to safety monitoring and to the control of reaction progress.The most promising applications of thermal methods are found in process development: enthalpimetric process investigation on the bench scale. Design principles for “process calorimeters” are outlined and applications to a pressure reaction, to a highly unstable radical reaction and to fermentations are shown.     

Scientific methods applied to the study of art objects

Scientific methods applied to the study of works of art are varied (examination, analysis and dating) and must be chosen with care in accordance with the object of the research. This paper briefly sets out the state of the art highlighting the development and applications of non-destructive methods. Such methods come under either the use of electromagnetic or particle radiation for the formation of images based on shape, development technique, or, on the other hand, the quantitative determination of elements down to and including their traces, isotopes or microsurfaces for the purpose of identifying the matter, its date, origin and development.     

大分子体系的量子化学分块方法

碎片化方法为量子化学方法的发展以及在大分子体系的应用开辟了新的道路。在过去的十年里,我们见证了该领域的诸多成果,并且我们相信该方法的发展仍将持续下去。这篇文章简单回顾了近期碎片化方法在大分子电子结构计算领域的进展,重点突出中国学者在该领域的贡献。     

Derivatography A complex method in thermal analysis

This review gives a survey of the theoretical considerations which led to the introduction of derivative methods in thennoanalysis, and of the development of complex thennoanalytical methods. The paper introduces the method of derivatography and its development, and surveys the wide field of its application in chemistry, technology, physical chemistry and biology.     

Applications of Protein Biochips in Biomedical and Biotechnological Research

Progress in the development of protein‐immobilization strategies and methods has made protein biochips increasingly accessible. The integration of these assay and analysis platforms into biomedical and biotechnological research has substantially expanded the repertoire of methods available for proteomics and biomarker research and for drug development. This Minireview highlights selected developments in the application of protein biochips in these fields.