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1.
Bakr F. Abdel-Wahab Hatem A. Abdel-Aziz Essam M. Ahmed 《Monatshefte für Chemie / Chemical Monthly》2009,20(7):601-605
Abstract
Potassium hydrazinecarbodithioate were prepared by treatment of acid hydrazides with carbon disulfide in the presence of potassium hydroxide. Reaction of this potassium salt with hydrazine hydrate, phenacyl bromide, or hydrazonoyl chlorides afforded 1,2,4-triazole, 1,3-thiazole, and 1,3,4-thiadiazoles. Reaction of 1,2,4-triazole with phenacyl bromide or hydrazonoyl chlorides afforded the corresponding 1,2,4-triazolo[3,4-b][1, 3, 4]-thiadiazines. All these new compounds were screened for antibacterial and antifungal activity. Some had promising activity. 相似文献2.
Hatem A. Abdel-Aziz Bakr F. Abdel-Wahab Marwa A. M. Sh. El-Sharief Mohamed M. Abdulla 《Monatshefte für Chemie / Chemical Monthly》2009,140(4):431-437
Abstract The reaction of 1-[4-(piperidin-1-yl)benzylidene]thiosemicarbazide with hydrazonoyl chlorides afforded 1,3-thiazole derivatives.
Cyclization of two compounds of the latter 1,3-thiazole by means of bromine in the presence of sodium acetate at room temperature
gave 1,3-thiazolo[2,3-c]-1,2,4-triazole derivatives. The reaction of 2-cyano-3-(4-piperidin-1-ylphenyl)prop-2-enethioamide with hydrazonoyl chlorides
under reflux in ethanol in the presence of triethylamine yielded 1,3-thiazoles. Treatment of 3-oxo-3-(piperidin-1-yl)propanenitrile
with phenyl isothiocyanate in DMF, in the presence of KOH, at ambient temperature, resulted in the formation of 3-anilino-3-mercapto-2-(piperidin-1-ylcarbonyl)acrylonitrile
which was reacted with hydrazonoyl chlorides to yield the corresponding 1,3,4-thiadiazole derivatives. Some of the newly synthesized
compounds had significant anti-arrhythmic activity.
Graphical Abstract
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3.
Sobhi M. Gomha 《Monatshefte für Chemie / Chemical Monthly》2009,140(2):213-220
Abstract The reaction of 2-mercapto-6,7,8,9-tetrahydro-3H-benzo[4,5]thieno[2,3-d]pyrimidin-4-one or its 2-methylthio derivative with hydrazonoyl halides, in the presence of triethylamine, yielded 6,7,8,9-tetrahydrobenzo[4,5]thieno[2,3-d]-1,2,4-triazolo[4,5-a]pyrimidin-5-ones. The structure of the latter compounds was further confirmed by reaction of 2-mercapto-6,7,8,9-tetrahydro-3H-benzo[4,5]thieno[2,3-d]pyrimidin-4-one with the appropriate active chloromethylenes followed by coupling of the products with benzenediazonium chloride
to afford the non-isolable azo-coupling products which converted, in situ, to 6,7,8,9-tetrahydrobenzo[4,5]thieno[2,3-d]-1,2,4-triazolo[4,5-a]pyrimidin-5-ones. The reaction mechanism was proposed and the products were screened for their biological activity. Some
of the newly synthesized compounds had a moderate effect against some bacterial and fungal species.
Graphical abstract
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4.
Bożena Modzelewska-Banachiewicz Barbara Michalec Teresa Kamińska Liliana Mazur Anna E. Kozioł Jacek Banachiewicz Marzena Ucherek Martyna Kandefer-Szerszeń 《Monatshefte für Chemie / Chemical Monthly》2009,140(4):439-444
Abstract (Z)-3-(3,4-diaryl-1,2,4-triazole-5-yl)prop-2-enoic acid derivatives were obtained in the course of the reaction of N
3-substituted amidrazones with maleic anhydride, and isomerized into the (E) isomers by heating under reflux in acetic acid solution. The molecular structure of the compounds obtained was confirmed
by IR and 1H NMR spectroscopy, and by X-ray crystallography for (2E)-3-(4,5-diphenyl-4H-1,2,4-triazol-3-yl)prop-2-enoic acid. The antiviral and immunomodulating activity of several of the compounds was examined.
Graphical abstract
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5.
Mohammad A. Khalilzadeh Issa Yavari Zinatossadat Hossaini Hasan Sadeghifar 《Monatshefte für Chemie / Chemical Monthly》2009,140(4):467-471
Abstract A novel method for oxazine ring formation is established using the reaction of ammonium thiocyanate and acid chlorides with
napthols in the presence of N-methylimidazole to afford [1,3]oxazine-4-thione derivatives in excellent yields.
Graphical abstract
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6.
Manas Chakrabarty Sulakshana Karmakar Ratna Mukherjee Shiho Arima Yoshihiro Harigaya 《Monatshefte für Chemie / Chemical Monthly》2009,140(4):375-380
Abstract 1-Alkyl/phenyl-2-arylbenzimidazoles have been synthesized in very good to excellent yields by a one-pot condensation of N-alkyl/phenyl-o-phenylenediamines with aryl aldehydes in water at room temperature using cetylpyridinium bromide as a cheap and eco-friendly
catalyst.
Graphical abstract
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7.
Wael A. El-Sayed Ibrahim F. Nassar Adel A.-H. Abdel-Rahman 《Monatshefte für Chemie / Chemical Monthly》2009,140(4):365-370
Abstract New C-furyl glycosides bearing pyrazolines, isoxazolines, and dihydropyrimidine-2(1H)-thiones were synthesized in order to increase the number of tested compounds screened for antimicrobial activity. The antimicrobial
activity screening showed that the pyrazoline derivatives were the most active compounds.
Graphical abstract
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8.
Marco Rupprich Clemens Decristoforo Barbara Matuszczak 《Monatshefte für Chemie / Chemical Monthly》2009,140(4):405-407
Abstract In contrast to the results presented in a previous report, the direct conversion of alcohols to alkyl fluorides with triphenylphosphine
and potassium fluoride in CCl4/DMF under mild conditions failed.
Graphical Abstract
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9.
Do-Min Lee Gullapalli Kumaraswamy Kee-In Lee 《Monatshefte für Chemie / Chemical Monthly》2009,140(1):73-78
Abstract Catalytic transfer hydrogenation of α-tosyloxyarylketones mediated by a chiral rhodium complex using an azeotropic mixture
of formic acid/triethylamine afforded the corresponding 1-arylethanediol monotosylates in excellent yield with high enantioselectivity.
Graphical abstract
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10.
Issa Yavari Rahimeh Hajinasiri S. Zahra Sayyed-Alangi 《Monatshefte für Chemie / Chemical Monthly》2009,140(2):205-207
Abstract 1-Ethyl-3-methylimidazolium bromide was used as a green recyclable alternative to volatile organic solvents for KOH catalyzed
three-component synthesis of diethyl alkylsulfanylmethylmalonates from aldehydes, diethyl malonate, and alkylthiols.
Graphical Abstract A synthesis of diethyl alkylsulfanylmethylmalonates catalyzed by KOH in an ionic liquid
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11.
Vera L. M. Silva Artur M. S. Silva Diana C. G. A. Pinto José A. S. Cavaleiro José Elguero 《Monatshefte für Chemie / Chemical Monthly》2009,140(1):87-95
Abstract An efficient synthesis method for the preparation of a series of new (Z)- and (E)-3(5)-(2-hydroxyphenyl)-4-styrylpyrazoles was developed. The reaction of (Z)- and (E)-3-styrylchromones with hydrazine hydrate afforded the corresponding (Z)- and (E)-3(5)-(2-hydroxyphenyl)-4-styrylpyrazoles, except for nitro derivatives, where both (Z)- and (E)-4′-nitro-3-styrylchromones afforded (E)-3(5)-(2-hydroxyphenyl)-4-(4-nitrostyryl)pyrazoles. The reaction mechanism for these transformations is discussed and the
stereochemistries of all products were established by NMR experiments.
Graphical abstract
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12.
Said Aly Said 《Monatshefte für Chemie / Chemical Monthly》2009,140(5):573-579
Abstract A series of pyridines, pyrimidines, and their derivatives were synthesized using 2-amino-6-methyl-4-phenylnicotinonitrile
as starting material. Thirteen new heterocyclics containing a pyridine ring were thus prepared. Pharmacological screening
showed that many of these compounds have good anti-inflammatory and analgesic activity comparable with those of diclofenac
potassium and valdecoxib as reference drugs. Assignment of the structures of the new compounds was based on chemical and spectroscopic
evidence. Synthesis, spectroscopic data, and pharmacological properties of the compounds are reported in detail.
Graphical Abstract
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13.
Abstract One-pot, three-components synthesis of 2,4,6-triarylpyridines and 5-unsubstituted-3,4-dihydropyrimidin-2(1H)-ones was performed under solvent-free conditions using molecular iodine as the catalyst in moderate to good product yields.
Graphical abstract
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14.
Barahman Movassagh Mohammad Soleiman-Beigi 《Monatshefte für Chemie / Chemical Monthly》2009,140(4):409-411
Abstract A simple, highly efficient, and green protocol has been developed for preparation of sulfides from alkyl or aryl thiols and
benzyl-, allyl-, t-butyl, and adamantyl halides under solvent- and catalyst-free conditions.
Graphical abstract
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15.
Jolanta Rousseau Vilija Kriščiūnienė Ilona Rimkevičiūtė Cyril Rousseau Virginė Amankavičienė Algirdas Šačkus Arnaud Tatibouët Patrick Rollin 《Monatshefte für Chemie / Chemical Monthly》2009,140(3):339-348
Abstract Modular conditions for the formation of thioureas or pyrimidine-4-one-2-thiones connected to the benzo[b]thiophene, benzene and indole structures were performed. A benzo[b]thiophene isothiocyanate derivative was used as a model to study the condensation with simple aromatic amines and amino-l-sorbose derivative. The construction of pyrimidine-4-one-2-thiones using basic conditions afforded efficiently new heterocyclic
aromatics, which were further transformed using the alkylated sulfur as a leaving group in palladium-catalyzed cross-coupling
reactions.
Graphical abstract
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16.
Svetlana Marković Sonja Stanković Slavko Radenković Ivan Gutman 《Monatshefte für Chemie / Chemical Monthly》2009,140(2):153-156
Abstract Two mechanisms for the isomerization of cyclopenta[fg]aceanthrylene to acefluoranthene were revealed. The first pathway occurs via a cyclobutyl intermediate, whereas the second
pathway involves a transition state that contains an sp
3-hybridized carbon atom. Both patterns show that the Stone-Wales rearrangement requires extremely high activation energy and
indicate that the isomerization process can occur only under a drastic temperature regime.
Graphical abstract
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17.
Jan Zawadiak Barbara Hefczyc Henryk Janeczek Marek Kowalczuk 《Monatshefte für Chemie / Chemical Monthly》2009,140(3):303-308
Abstract New azo-perester derivatives of tert-butyl and tert-amyl hydroperoxides were obtained in reactions of azo acid chlorides with hydroperoxides in the presence of an inorganic
base. Obtained azo-peresters possess two kinds of the labile functional groups: the azo group and also the perester group.
The data from DSC experiments indicate that in the case of azo-perester derivatives of tert-amyl hydroperoxide, the perester group decomposes at a somewhat lower temperature than in the case of tert-butyl derivatives, whereas azo groups decompose at somewhat higher temperature in the case of derivatives with tert-amyl substituent.
Graphical abstract
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18.
Robabeh Baharfar Seyed M. Vahdat Fatemeh G. Hakimabadi 《Monatshefte für Chemie / Chemical Monthly》2009,140(5):489-493
Abstract An efficient one-pot reaction of dialkyl acetylenedicarboxylates with 2,4-dihydroxybenzo(or aceto)phenones in the presence
of triphenylphosphine produces 5-hydroxy- and 7-hydroxycoumarin derivatives. The novel procedure features short reaction time,
fairly good yields, and simple workup.
Graphical abstract
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19.
Mohammad Anary-Abbasinejad Hossein Anaraki-Ardakani Fatemeh Ghanea 《Monatshefte für Chemie / Chemical Monthly》2009,140(4):397-400
Abstract The reactive intermediate generated by the reaction of alkyl isocyanides and dialkyl acetylenedicarboxylates was trapped by
ethyl carbazones to produce stable ketenimine derivatives in good yield. The reaction is characterized by mild conditions,
high selectivity, and tolerance to various functional groups.
Graphical abstract
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20.
Mohamed A. A. Radwan Marwa A. Shehab Siham M. El-Shenawy 《Monatshefte für Chemie / Chemical Monthly》2009,140(4):445-450
Abstract 5-Aminobenzo[b]thiophene-2-carboxylic acid was converted to the corresponding 5-(2-chloroacetamido)benzo[b]thiophene-2-carboxylic acid by reaction with chloroacetyl chloride. This acetamido product was treated with different alkyl,
cycloalkyl, aryl, and heterocyclic amines to afford a series of C5-substituted benzo[b]thiophenes. These compounds were found to possess potent anti-inflammatory activity.
Graphical abstract
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