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1.
Eduardo Corts Corts Raúl Salazar Franco Olivia García Mellado 《Journal of heterocyclic chemistry》2001,38(3):663-669
A series of twelve new 2‐[(o‐ and p‐substituted)aminophenyl]‐3H‐5‐[(o‐ and p‐substituted)phenyl]‐7‐chloro‐1,4‐benzodiazepines, which have possible pharmacological properties has been obtained. The synthesis was carried out following six steps. The structure of all products was corroborated by ir, 1H nmr, 13C nmr and ms. In addition for the compound 2‐(o‐chloroaminophenyl)‐3H‐5‐(o‐fluorophenyl)‐7‐chloro‐1,4‐benzodiazepine 7, its structure was confirmed by X‐ray diffraction. 相似文献
2.
Eduardo Corts Corts Cristina A. Corts Romero Olivia García Mellado 《Journal of heterocyclic chemistry》2002,39(6):1321-1324
A series of eleven new 2‐methylthio‐3H‐7‐[(o‐; m‐ and p‐substituted) phenoxy]‐4‐(p‐substituted‐phenyl)‐[1,5]benzodiazepines, which have potentially useful pharmacological activities, has been synthesized by condensing the 4‐[(o‐; m‐ and p‐R1)phenoxy]‐1,2‐phenylendiamines with 3,3‐dimercapto‐1‐(p‐R2‐phenyl)‐2‐propen‐1‐one. Afterward the lH‐[1,5]benzodiazepine‐2‐thiones obtained were treated with sodium hydride and methyl iodide. The structure of all products was corroborated by ir, 1H nmr, 13C nmr and ms. 相似文献
3.
Eduardo Cortés Erik Peréz Ramírez Olivia García‐Mellado de Cortés 《Journal of heterocyclic chemistry》2007,44(1):189-192
A new synthesis to obtain eight novel derivatives of 1‐[(p‐substituted)phenyl]‐3a‐[(o‐ and p‐substituted)‐phenyl]‐5‐chloro‐9‐methylthio‐10,3a‐dihydro‐[1,2,4]‐oxadiazolo[2,3‐b][1,4]benzodiazepines with possible biological and pharmacological activity as anxiolytics, hypnotics, anticonvulsants in the central nervous system. The final products were obtained by condensation between 2‐methylthio‐5‐[(o‐; p‐substituted)‐phenyl]‐3H‐7‐chloro‐[1,4]benzodiazepine with benzonitrile oxide generated in situ from benzohydroxamoyl chloride in triethylamine. The structure of all products was corroborated by ir, 1H‐nmr, 13C‐nmr, with experiments bidimensional and ms in low and high resolution. 相似文献
4.
Eduardo Corts Corts Isidro Ebromares Martínez Olivia García Mellado 《Journal of heterocyclic chemistry》2002,39(6):1189-1193
A series of twelve new 7‐chloro‐5‐[(o‐ and p‐R1)phenyl]‐1‐R2‐3H‐[1,4] benzo‐diazepin‐2‐ones, which have possible pharmacological properties were synthesized. The synthesis of all the final compounds was carried out by four steps. The structure of all final products was corroborated by ir, 1H nmr, 13C nmr and ms, and have been obtained in 35‐94% yield. 相似文献
5.
Eduardo Cortas Cortas Ana María Hernndez Sanabria Olivia García Mellado 《Journal of heterocyclic chemistry》2002,39(1):55-59
The preparation of twelve novel 2,3,4,5,10,11‐hexahydro‐1H‐dibenzo[b,e] [1,4]diazepin‐l‐ones which have potentially useful pharmacological properties; by condensation and cyclization between 3‐{[4‐(o‐; m‐; p‐methoxy)phenylthio]‐1,2‐phenylenediamine}‐5,5‐dimethyl‐2‐cyclohexenone with (o‐; and p‐substi‐tuted)benzaldehyde. The structure of all final products were corroborated by ir, 1H‐nmr, 13C‐nmr and ms. 相似文献
6.
Eduardo Corts Corts Rafael Sosa Mendoza Maximiliano Santibez Gutirrez Olivia Garca‐Mellado De Corts 《Journal of heterocyclic chemistry》2004,41(2):273-276
The preparation and spectral properties often novel methyl 5‐[(o‐, m‐, and p‐substituted)‐phenylthio]‐2‐benzimidazolecarbamates with possible pharmacological activity as antihelmintics is described; by condensation and cyclization between 5‐methylthioures sulfate chloroformic acid methyl ester and 3,4‐diaminophenyl‐substituted‐phenylthio ether dissolved in ethanol. The structures of all final products were corroborated by ir; 1H‐nmr, 13C‐nmr and ms. 相似文献
7.
Eduardo Cortés Cortés Ana L. Valencia Cornejo Olivia García‐Mellado de Cortés 《Journal of heterocyclic chemistry》2007,44(1):183-187
An efficient synthesis of four steps to obtain twelve new derivatives of 3,3‐dimethyl‐2,3,4,5,10,11‐hexahydro‐8‐[(o‐; and p‐methoxy)phenoxy]‐11‐[(o‐; and p‐R)phenyl]‐1H‐dibenzo[b,e][1,4]diazepin‐1‐ones IV, 1‐12 with possible biological and pharmacological activity as anticonvulsant and schizophrenia treatment in the central nervous system (CNS). The final products were obtained by condensation and cyclization between 3‐{4‐[(o‐; and p‐methoxy)phenoxy]‐1,2‐phenylenediamine}‐5,5‐dimethyl‐2‐cyclohexenone with (o‐; and p‐R)benzaldehyde. The structure of all products was corroborated by spectroscopy of ir, 1H‐nmr, 13C‐nmr, with bidimensional experiments and MS in Low and high resolution with Collision‐Induced Dissociation experiments (CID). 相似文献
8.
Kazunori Sakata Junichi Yamashita Mamoru Hashimoto Akihiko Tsuge Yasuhiro Tanoue 《Journal of heterocyclic chemistry》2001,38(4):933-938
The diazo coupling reaction between a tetraaza[14]annulene ( 1 ) and a series of 4‐substituted phenyl‐diazonium tetrafluoroborates yielded the corresponding 7, 16‐disubstituted products. Mass spectra indicate the presence of molecular ion peaks that substantiate the 7,16‐disubstituted products ( 4 ); the lack of olefinic proton signals corresponding to the 7,16‐ position in the 1H nmr spectra of 4 also show that diazo coupling has taken place. Analysis of signals corresponding to the methyl groups of 4 in their 1H and 13C nmr spectra indicate that the imine‐bis‐hydrazone form is present for compounds that do not contain p‐methoxyphenyl groups. However, analysis of methyl signals in the nmr specta of compounds 4 containing p‐methoxyphenyl groups show that the bis‐azo form and the imine‐bis‐hydrazone form are present through tautomerism. Complexation with nickel(II) ion induces the formation of the bis‐ azo structure. 相似文献
9.
A series of m‐ and p‐substituted 1‐phenyl, 1‐benzyl, 1‐benzoyl, and 1‐(2‐phenylethyl)pyrroles was prepared and their 1H and 13C nmr spectroscopic characteristics were examined. In general, good correlations were observed between the chemical shift values of the β? H and the β? C of pyrroles [except 1‐(2‐phenylethyl)pyrroles] and the Hammettt σ. The observation may be explained in terms of the electronic effects of the substituents which are transmitted through bonds and through space by interaction of the p orbitals between β? Cs of the pyrrole ring and m‐ and p? Cs of the phenyl ring. Substituent constants of 1‐pyrrolyl, 1‐pyrrolylmethyl, and 1‐pyrroloyl groups for the 1H and 13C chemical shifts of phenyl ring are also presented. 相似文献
10.
C. Suresh Reddy Y. Hari Babu N. Ravi Sankar C. Devendranath Reddy 《Journal of heterocyclic chemistry》2004,41(6):1027-1031
Novel 3‐(substituted)‐2,4,8,15‐tetroxa‐3‐phosphadispiro[5.2.5]hexadecane‐3‐oxides (3‐12) have been synthesized by cyclization of 1,5‐dioxaspiro[5.5]undecande‐3,3‐dimethanol (1) with various substituted aryl phosphorus dichloridates (2) in dry toluene‐THF in the presence of triethylamine at 40‐60 oC. Their molecular structures were determined by ir, nmr and mass spectral studies and were screened for antifungal activity against Curvularia lunata and Aspergillus niger, and antibacterial activity on Staphylococcus aureus and Escherichia coli. Most of them possess significant activity. 相似文献
11.
Daniel E. Lynch Gillian E. Spicer Ian Mcclenaghan 《Journal of heterocyclic chemistry》2005,42(7):1363-1368
Three α‐phenylmalonamides have been prepared by the selective nucleophilic cleavage of 5,7‐dimethyl‐2‐phenyl‐1‐oxo‐1H‐pyrazolo[1,2‐a]pyrazol‐4‐ylium‐3‐olate in solventless microwave syntheses. The three weak nucleophiles employed were aniline, p‐chloroaniline and m‐toluidine. The α‐phenylmalonamides of these three aniline derivatives could not be prepared using the previously reported solvent syntheses via 3‐oxopyrazolo[1,2‐a]pyrazol‐8‐ylium‐1‐olates. All products were characterised using, infrared spectroscopy, 1H nmr and electrospray mass spectrometry. The single crystal X‐ray structures of the starting pyrazolo‐[1,2‐a]pyrazole and α‐phenylmalon‐m‐toluidide are also reported. 相似文献
12.
This paper describes a method of preparation of new 3,5′‐dioxo‐2′‐phenyl‐1,3‐dihydrospiro[indene‐2,4′‐[1,3]oxazol]‐1‐yl acetate and its 5‐chloro‐ and bromoderivatives as products of interaction of N‐benzoylglycine (hippuric acid) with corresponding ortho‐formylbenzoic acids. The reaction carried out in acetic anhydride media in the presence of piperidine as catalyst. The novel spirocompounds were purified by column chromatography from multicomponent reaction mixtures. The composition of the spiro‐products was confirmed by C, H, N element analysis. The structure was established by IR, MS, 1H‐ and 13C‐NMR analysis including COSY 1H‐13C experiments. 相似文献
13.
《Journal of heterocyclic chemistry》2017,54(5):2605-2613
A series of novel isoxazole, dihydropyrazolone, and tetrahydropyridine derivatives were synthesized by the reaction of corresponding ethyl 1‐substituted aryl‐2‐methyl‐4‐oxo‐1,4,5,6‐tetrahydropyridine‐3‐carboxylates with different hydrazines and hydroxylamine. Reaction of tetrahydropyridone with N ,N‐dimethylformamide dimethyl acetal provided 1‐(5‐chloro‐2‐methylphenyl)‐2‐[2‐(dimethylamino)ethenyl]‐4‐oxo‐1,4,5,6‐tetrahydropyridine‐3‐carboxylate, which was cyclized into a bicyclic compound on treatment with ammonium acetate. The structures of all synthesized compounds were confirmed by IR, 1H NMR, and 13C NMR spectroscopy data. The structure of 5‐(5‐chloro‐2‐methylphenyl)‐4‐methyl‐2‐phenyl‐2,5,6,7‐tetrahydro‐3H‐pyrazolo[4,3‐c]pyridin‐3‐one was unambiguously assigned by means of X‐ray analysis data. 相似文献
14.
Jun‐Bao Liu Yuan Lu Chao‐Jun Chen Shi‐Kui Wu Meng‐Shen Cai 《Journal of heterocyclic chemistry》2013,50(6):1441-1445
5‐amino‐tetrazolo[1,5‐a]pyrimidin‐7‐ol ( I ) was synthesized by reaction of 5‐amino‐tetrazole with ethyl cyanoacetate in excellent yield. A series of novel 5‐amino‐6‐arylazotetrazolo[1,5‐a]pyrimidin‐7‐ol dyes were prepared by linking o‐, m‐, p‐anisidine, o‐, m‐, p‐chloroaniline, o‐, m‐, p‐nitroaniline, o‐, m‐, p‐toluidine and aniline to 5‐amino‐tetrazolo[1,5‐a]pyrimidin‐7‐ol ( I ). The structure of these dyes were confirmed by UV‐vis, FTIR and 1H NMR spectroscopic techniques and elemental analysis. The effect of varying pH and solvent upon the absorption ability of 5‐amino‐6‐arylazotetrazolo[1,5‐a]pyrimidin‐7‐ol sudstituted with electron‐withdrawing and electron‐donating groups at their o‐, m‐, p‐position was examined. 相似文献
15.
Jiann‐Kuan Luo Maria‐Paz Cabal Ronald F. Federspiel Raymond N. Castle 《Journal of heterocyclic chemistry》2001,38(1):137-140
A previously unknown heterocyclic ring system, naphtho[2′,1′:4,5]thieno[2,3‐c]naphtho[2,1‐f]quinoline ( 14 ), was synthesized via oxidative photocyclization of 3‐chloro‐N‐(2‐phenanthryl)naphtho[1,2‐b]‐thiophene‐2‐carboxamide ( 9 ). Further elaboration of the lactam 10 yielded the unsubstituted ring system 14 . Structural confirmation of compound 14 was accomplished by a total assignment of its 1H and 13C nmr spectra utilizing the concerted two‐dimensional nmr spectroscopic methods. 相似文献
16.
Giuliana Biagi Fabio Ciambrone Irene Giorgi Oreste Livi Valerio Scartoni Pier Luigi Barili 《Journal of heterocyclic chemistry》2002,39(5):889-893
New tricyclic 1,2,3‐triazolo‐1,2,4‐triazolo‐pyridazine derivatives, bearing a methyl substituent on the 1,2,3‐triazole ring, were prepared as potential biological agents. N‐Methylation of dimethyl 1,2,3‐triazole‐4,5‐dicarboxylate allowed synthesis of the isomeric 1‐methyl‐4,7‐dihydroxy and 2‐methyl‐4,7‐dihydroxy triazolo‐pyridazines 4a and 4b which, by a chlorination reaction, gave the corresponding 1‐methyl‐4‐chloro‐( 6a ), 1‐methyl‐7‐chloro‐ ( 6b ) and 2‐methyl‐4‐chloro‐ ( 9 ) substituted 1,2,3‐triazolo‐pyridazines. The nucle‐ophilic substitution with hydrazine hydrate and the suitable cyclization to form the 1,2,4‐triazole ring, provided the expected tricyclic isomeric derivatives 8a, 8b and 11 respectively. The p‐methoxybenzyl substituent, introduced as a leaving group to obtain either v‐triazolo‐pyridazine or v‐triazolo‐s‐triazolo‐pyri‐dazine derivatives unsubstituted on the 1,2,3‐triazole ring, appeared inadequate. Some compounds underwent binding assays toward the adenosine A1and A2A receptors. 相似文献
17.
Reaction of 4H‐pyrimido[2,1‐b]benzothiazole‐2‐thiomethyl‐3‐cyano‐4‐one (1) with hydrazine hydrate/aryl hydrazine/heteryl hydrazine in the presence of anhydrous potassium carbonate and dimethyl formamide afforded 3‐amino‐4‐oxo‐(2H)/aryl/heteryl pyrazolo[3′,4′:4,5]pyrimido[2,1‐b]benzothiazoles in good yield. These pyrazole derivatives on diazotization followed by replacement with hydroxy, chloro, bromo, iodo and on reduction gave the corresponding 3‐substituted derivatives. 相似文献
18.
Treatment of 1,(3)‐(di)substituted 4‐benzoyl‐5‐hydroxypyrazoles with phosphorus oxychloride affords the corresponding 4‐benzoyl‐5‐chloropyrazoles. Reaction of the latter with hydroxylamine leads to oximes, which can be cyclized to novel 3‐phenyl‐6H‐pyrazolo[4,3‐d]isoxazoles by treatment with sodium hydride in dimethyl formamide. Detailed nmr spectroscopic studies (1H, 13C) with all obtained compounds are presented. 相似文献
19.
Giuliana Biagi Irene Giorgi Oreste Livi Federica Pacchini Valerio Scartoni 《Journal of heterocyclic chemistry》2002,39(5):885-888
The 7‐chloro‐3‐(2‐chlorobenzyl)‐ and 7‐chloro‐3‐(2‐fluorobenzyl)‐1,2,3‐triazolo[4,5‐d]pyrimidines ( 1 and 4 ), by nucleophilic replacement with some hydrazides, gave the corresponding 7‐hydrazidoderivatives ( 2a‐e and 5a‐e ). These, by heating in Dowtherm, underwent an intramolecular cyclization to form the new tricyclic 7‐substituted‐3‐(2‐chlorobenzyl)‐ and 3‐(2‐fluorobenzyl)‐1,2,3‐triazolo[4,5‐e]1,2,4‐triazolo[4,3‐c]pyrimidines ( 3a‐d and 6a‐d ). The 7‐hydrazino‐3‐(2‐chlorobenzyl)‐ and 7‐hydrazino‐3‐(2‐fluorobenzyl)‐triazolo‐pyrimidines ( 9a and 9b ) were also prepared via the corresponding mercapto ( 7a and 7b ) and thiomethyl ( 8a and 8b ) derivatives. 相似文献
20.
Synthesis and asymmetric anionic polymerization of substituted 7‐aryl‐2,6‐dimethyl‐1,4‐benzoquinone methides 下载免费PDF全文
Takahiro Uno Hiroshi Ohta Atsushi Yamane Masataka Kubo Takahito Itoh 《Journal of polymer science. Part A, Polymer chemistry》2015,53(3):437-444
Substituted 7‐aryl‐2,6‐dimethyl‐1,4‐benzoquinone methides which have an electron‐donating methoxy substituent at the para‐position (p‐OMe, 2a ) or an electron‐withdrawing chloro one at the para‐ (p‐Cl, 2b ), meta‐ (m‐Cl, 2c ) , and ortho‐positions (o‐Cl, 2d ) of the benzene ring were synthesized, and their asymmetric anionic polymerizations using the complex of lithium 4‐isopropylphenoxide with (?)‐sparteine were carried out in toluene at 0 °C. The polymers with negative specific rotation were obtained for all of four monomers, and the polymer obtained from 2a showed smaller specific rotation value than that of polymer having no substituent (p‐H, 1 ) on the phenyl group and the polymers obtained from 2b–d showed larger ones. It was found that the kind of a substituent and its substitution position on the phenyl group affect significantly the optical activity of polymers. The largest specific rotation value of [α]435= ?153.2° was obtained in the polymerization of 2d with an ortho‐chloro substituent. © 2014 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2015 , 53, 437–444 相似文献