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Denis Descours Didier Festal Jean-Michel Leger Alain Carpy 《Helvetica chimica acta》1991,74(8):1757-1763
Optical Isomers of Naftidrofuryl( = 2-(Diethylamino)ethyl 2-[(Naphth-1-yl)methyl]-3-(tetrahydrofur-2-yl)propanoate) The four optical isomers of naftidrofuryl ( 1 ) were prepared in two ways, by separation and resolution of the two diastereoisomeric racemates and by synthesis from the enantiomers of tetrahydrofuran-2-methanol ( 6 ); see Scheme}. The absolute configuration of one of the isomer as a tartrate monohydrate was established by X-ray crystallography thus allowing the deduction of the absolute configurations of the other three optical isomers. 相似文献
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A facile synthesis of hitherto unreported benzofuran-2-yl(9-methyl-9H-carbazol-3-yl)methanones (3a?Cl) is described. The synthesis mainly relies on the ultrasound-assisted Rap?CStoermer reaction of 3-chloroacetyl-9-methyl-9H-carbazole (1) with a variety of salicylaldehydes, as well as 2-hydroxy-1-naphthaldehyde (2) in CH3CN, with the presence of PEG-400 as a catalyst. This procedure offers easy access to benzofuran-2-yl(carbazolyl)methanone derivatives in a short reaction time and the products are achieved in good yields. 相似文献
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Hakan Kandemir 《合成通讯》2013,43(22):2583-2591
A simple and efficient synthesis of novel 3-(benzimidazol-2-yl)- and 3,6-di(benzimidazol-2-yl)-9-ethyl-9H-carbazoles is described. The synthetic approach for the preparation of 2-substituted benzimidazoles 4–8 and bis-benzimidazoles 9–12 was achieved by the condensation of carbazole-3-carbaldehyde 2 and carbazole-3,6-dicarbaldehyde 3 with o-phenyldiamines in dimethylformamide or dimethylsulfoxide in moderate to excellent yield. The identities of synthesized compounds were confirmed using 1H NMR, 13C NMR, infrared (IR), and high-resolution mass spectrometry (HRMS). 相似文献
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V. G. Artamoshkin V. A. Bushmelev A. M. Genaev V. G. Shubin 《Russian Journal of Organic Chemistry》2006,42(9):1257-1263
1H NMR study has shown that long-lived 9-R-9,10-dimethylphenanthren-9-yl cations (R = isopropenyl, trans-1-methylprop-1-en-1-yl) generated in the system HSO3F-SO2ClF-CD2Cl2 at ?130°C undergo degenerate rearrangement via 1,2-vinyl shifts (ΔG’ = 37 and 39 kJ/mol, respectively, at ?88°C). Analysis of the geometric parameters of the initial structures and transition states calculated by the DFT method indicates that unfavorable steric factors are responsible for the sharp deceleration of 1,2-shifts of the isopropenyl and trans-1-methylprop-1-en-1-yl groups as compared to vinyl and cis-1-methylprop-1-en-1-yl groups, respectively. 相似文献