Electroanalytical Sensor Based on Unmodified Screen‐Printed Carbon Electrode for the Determination of Levo‐Thyroxine |
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| Authors: | Ashis Das M V Sangaranarayanan |
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| Affiliation: | Department of Chemistry, Indian Institute of Technology, Madras, Chennai‐600036, India |
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| Abstract: | The electrochemical behaviour of thyroxine (T4) is analysed using the disposable screen‐printed carbon electrode (SPCE) in the neutral phosphate buffer solution with cyclic voltammetric technique. The Differential Pulse Voltammetry and Chronoamperometry were employed for sensing of T4. The lowest detection limit of 3 nM was obtained from the differential pulse voltammetric method without preconditioning. The Density Functional Theoretical study of T4 was performed to elucidate the mechanism of oxidation. The analysis of the commercial pharmaceutical samples indicates the validity of the proposed method. |
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| Keywords: | Amperometry Density functional theory Differential pulse voltammetry Levo‐thyroxine Screen‐printed carbon electrode |
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