| In Vivo Monitoring of Neovascularization in Tumour Angiogenesis by Photoacoustic Tomography |
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| 作者姓名： | 向良忠 邢达 谷怀民 周非凡 杨迪武 曾吕明 杨思华 |
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| 作者单位： | MOE Key Laboratory of Laser Life Science and Institute of Laser Life Science, South China Normal University, Guangzhou 510631 |
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| 基金项目： | Supported by the National Natural Science Foundation of China under Grant Nos 60378043 and 30470494, and the Natural Science Foundation of Guangdong Province under Grant Nos 015012, 04010394 and 2004B10401011. |
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| 摘 要： | Photoacoustic tomography （PAT） is presented to in vivo monitor neovascularization in tumour angiogenesis with high resolution and high contrast images in a rat. With a circular scan system, the photoacoustic signal, generated by laser pulses at a wavelength of 532nm from a Q-switched Nd：YAG laser is captured by a hydrophone with a diameter of 1 mm and a sensitivity of 850nV/Pa. The vascular structure around the rat tumour is imaged clearly, with optimal contrast, because blood has strong absorption near this wavelength. Serial noninvasive photoacoustic images of neovascularization in tumour angiogenesis are also obtained consecutively from a growing tumour implanted under the skin of a rat over a period of two weeks. This work demonstrates that PAT can potentially provide a powerful tool for tumour angiogenesis detection in cancer research. It will bring us closer to clinical applications for tumour diagnosis and treatment monitoring.
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| 关 键 词： | X线断层摄影术 肿瘤学 检测方法 新血管化 |
| 收稿时间： | 2006-8-4 |
| 修稿时间： | 2006-08-04 |
In Vivo Monitoring of Neovascularization in Tumour Angiogenesis by Photoacoustic Tomography |
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| XIANG Liang-Zhong,XING Da,GU Huai-Min,ZHOU Fei-Fan,YANG Di-Wu,ZENGLv-Ming,YANG Si-Hua.In Vivo Monitoring of Neovascularization in Tumour Angiogenesis by Photoacoustic Tomography[J].Chinese Physics Letters,2007,24(3):751-754. |
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| Authors: | XIANG Liang-Zhong XING Da GU Huai-Min ZHOU Fei-Fan YANG Di-Wu ZENGLv-Ming YANG Si-Hua |
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| Affiliation: | MOE Key Laboratory of Laser Life Science and Institute of Laser Life Science, South China Normal University, Guangzhou 510631 |
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| Abstract: | Photoacoustic tomography (PAT) is presented to in vivo monitor neovascularization in tumour angiogenesis with high resolution and highcontrast images in a rat. With a circular scan system, the photoacoustic signal, generated by laser pulses at a wavelength of 532nm from a Q-switched Nd:YAG laser, is captured by a hydrophone with a diameter of 1mm and a sensitivity of 850nV/Pa. The vascular structure around the rat tumour is imaged clearly, with optimal contrast, because blood has strong absorption near this wavelength. Serial noninvasive photoacoustic images of neovascularization in tumour angiogenesis are also obtained consecutively from a growing tumour implanted under the skin of a rat over a period of two weeks. This work demonstrates that PAT can potentially provide a powerful tool for tumour angiogenesis detection in cancer research. It will bring us closer to clinical applications for tumour diagnosis and treatment monitoring. |
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| Keywords: | 43 25 +d 87 57 Ce 43 60 +d 43 80 +p |
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