Aliphatic Organoimido Derivatives of Polyoxometalates Containing a Bioactive Ligand |
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| Authors: | Shan She Shengtai Bian Prof?Dr Jian Hao Dr Jiangwei Zhang Jin Zhang Prof?Dr Yongge Wei |
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| Affiliation: | 1. Analysis and Test Center, Beijing University of Chemical Technology, Beijing 100029 (P. R. China), Fax: (+86)?10‐64412796;2. State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100191 (P. R. China);3. Department of Chemistry, Tsinghua University, Beijing 100084 (P. R. China);4. Department of Biomedical Engineering, Tsinghua University School of Medicine, Beijing 100084 (P. R. China) |
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| Abstract: | A series of aliphatic organoimido derivatives of hexamolybdate based on amantadine, namely (nBu4N)2Mo6O18(?NC10H15)] ( 1 ), (nBu4N)2 {cis‐Mo6O17(?NC10H15)2]} ( 2 ), (nBu4N)2{trans‐Mo6O17(?NC10H15)2]} ( 3 ), and (nBu4N)2Mo6O16(?NC10H15)3] ( 4 ), was synthesized in reasonable yield by dehydration with N,N′‐dicyclohexylcarbodiimide (DCC). They were characterized by IR and UV/Vis spectroscopy, elemental analysis, ESI mass spectrometry, and single‐crystal X‐ray structure analysis. The spectral and structural similarities and differences between monosubstituted, cis‐disubstituted, and trans‐disubstituted organoimido derivatives were elucidated and may provide guidance for related work on organoimido‐functionalized Lindqvist‐type polyoxometalates. In addition, trans‐disubstituted and polysubstituted derivatives containing aliphatic organoimido ligands have not yet been reported, and the crystal structure of the trans isomer may lead us to a deeper understanding of disubstituted derivatives. Furthermore, proliferation and morphology of MCF‐7 cells were studied with compound 1 . The present results show that the DCC‐dehydrating protocol could be an efficient approach to covalently graft bioactive ligands such as amantadine onto POMs and enhance their application in clinical cancer treatment. |
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| Keywords: | amines antiproliferation imide ligands molybdenum polyoxometalates |
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