Copper‐Catalyzed NH Insertion and Oxidative Aromatization Cascade: Facile Synthesis of 2‐Arylaminophenols |
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| Authors: | Dong Ding Xiaobing Lv Dr Jian Li Guangyang Xu Dr Bing Ma Prof?Dr Jiangtao Sun |
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| Affiliation: | School of Pharmaceutical Engineering&Life Science, Changzhou University, Changzhou 213164 (P. R. China), Fax: (+86)?519‐86334598 |
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| Abstract: | A copper‐catalyzed cascade reaction of N‐H insertion and oxidative aromatization has been developed. 2‐Arylaminophenols have been prepared in moderate to high yields from the diazo substrates. Moreover, this newly established methodology allows efficient access to natural 1‐oxygenated carbazole alkaloids, such as glycozolicine and murrayafoline A. |
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| Keywords: | aromatization copper diazo compounds domino reactions homogeneous catalysis |
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