Ruthenium Complex “Light Switches” that are Selective for Different G‐Quadruplex Structures |
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| Authors: | Erin Wachter Diego Moyá Dr Sean Parkin Dr Edith C Glazer |
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| Affiliation: | Department of Chemistry, University of Kentucky, 505 Rose Street, Lexington, KY 40506 (USA) |
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| Abstract: | Recognition and regulation of G‐quadruplex nucleic acid structures is an important goal for the development of chemical tools and medicinal agents. The addition of a bromo‐substituent to the dipyridylphenazine (dppz) ligands in the photophysical “light switch”, Ru(bpy)2dppz]2+, and the photochemical “light switch”, Ru(bpy)2dmdppz]2+, creates compounds with increased selectivity for an intermolecular parallel G‐quadruplex and the mixed‐hybrid G‐quadruplex, respectively. When Ru(bpy)2dppz‐Br]2+ and Ru(bpy)2dmdppz‐Br]2+ are incubated with the G‐quadruplexes, they have a stabilizing effect on the DNA structures. Activation of Ru(bpy)2dmdppz‐Br]2+ with light results in covalent adduct formation with the DNA. These complexes demonstrate that subtle chemical modifications of RuII complexes can alter G‐quadruplex selectivity, and could be useful for the rational design of in vivo G‐quadruplex probes. |
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| Keywords: | G‐quadruplexes light switch photochemistry photophysics ruthenium |
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