| 由4-甲基-1,2,3-噻二唑-5-甲酸构筑的铜配合物的合成、晶体结构及与DNA作用 |
| Synthesis, Crystal Structures and DNA-Binding of Two Novel Copper(Ⅱ)Complexes Constructured by 4-Methyl-1,2,3-Thiadiazol-5-Carboxylic Acid |
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| 摘要: 由4-甲基-1,2,3-噻二唑-5-甲酸(HMTC,C4H4N2O2S)和邻菲罗啉(phen)合成了两个新的铜配合物[Cu(MTC)2(H2O)2]n(1)，[Cu2(MTC)2(Phen)2(H2O)4]MTC2(2)。用元素分析、红外光谱、热重分析、粉末X射线衍射进行表征，用单晶X-衍射方法测定了配合物的晶体结构。结果表明，配合 物1属于单斜晶系，P21/c空间群，是一个单核结构，中心金属铜(II)离子采用五配位形式形成了一个畸变的四方锥结构。配合物2属于三斜晶系，Pī空间群，是一个双核结构，由两个配位水分子上的氧桥连两个铜(II)离子形成六配位的扭曲八面体结构。用溴化乙锭荧光探针测定了配体和配合物与DNA的相互作用，结果显示无论是配体还是配合物均能使EB-DNA复合体系的荧光发生不同程度的淬灭，且配合物的作用强度大于配体，具有刚性平面辅助配体的配合物2的作用强度又大于不加辅助配体的配合物1。CCDC: 825716,1; 1435439,2. |
| 关键词: 铜配合物 4-甲基-1,2,3-噻二唑-5-甲酸 晶体结构 DNA作用 |
| 基金项目: |
| Abstract: Two novel copper complexes [Cu(MTC)2(H2O)2]n(1) and [Cu2(MTC)2(Phen)2(H2O)4]MTC2(2) were synthesized by 4-methyl-1,2,3-thiadiazol-5-carboxylic acid(HMTC, C4H4N2O2S) and 1,10-phenanthroline(phen), and structurally characterized by elemental analysis, IR spectra, TG, PXRD and single crystal X-ray diffraction method. The single crystal X-ray diffraction reveals that the 1 was a mononuclear structure, crystallized in monoclinic with space group P21/c. Central metal Cu2 was five-coordinated forming a distorted pentahedron coordination geometry. The 2 was a binuclear structure, which was bridged by two oxygen atoms from two coordinated water, crystallized in triclinic with space group Pī. Central metal Cu2 was six-coordinated forming a distorted octahedron coordination geometry. In addition, the interaction of complexes and ligand with DNA were also studied by ethidium bromide fluorescence probe, the interaction of complex 2 with DNA was stronger than complex 1. CCDC: 825716, 1; 1435439, 2. |
| Keywords: Copper complex 4-methyl-1,2,3-thiadiazol-5-carboxylic acid crystal structure DNA-binding |
| 投稿时间：2016-04-18 修订日期：2016-06-29 |
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