High-Performance Liquid Chromatographic Method for the Determination of Nimesulide in Pharmaceutical Preparations |
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Authors: | B S Nagaralli J Seetharamappa B G Gowda M B Melwanki |
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Institution: | (1) Department of Chemistry, Karnatak University, Dharwad, 580003, India |
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Abstract: | A simple, rapid, and precise high-performance liquid chromatographic method for the determination of nimesulide in pharmaceutical preparations was proposed using Ibuprofen as an internal standard. The separation was performed on a CLC C18 (5 m, 25 cm × 4.6 mm i.d.) column with a mobile phase consisting of an acetonitrile–0.05 M KH2PO4 buffer mixture of pH 7.00 (55 : 45, v/v). The detection was carried out at 230 nm and the linearity range was found to be 0.5–100 g/mL. The method has been applied successfully to the determination of nimesulide in pharmaceutical formulations. The recovery values were found to be in the range of 99.23–100.13% with RSD values of less than 0.97%. |
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