DNA and PNA as templates for building nanoassemblies via electrostatic complexation with gold nanoparticles |
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| Affiliation: | 1. Research Unit Plasma Technology (RUPT), Department of Applied Physics, Ghent University, Sint-Pietersnieuwstraat 41, B4, B-9000 Ghent, Belgium;2. Chimie des Interactions Plasma-Surface (ChIPS), CIRMAP, Université de Mons, 20 Place du Parc, B-7000 Mons, Belgium;3. Tissue Engineering Group, Department of Basic Medical Sciences, Ghent University, De Pintelaan 185, B3, B-9000 Ghent, Belgium;1. Marine-Integrated Bionics Research Center, Pukyong National University, Busan 48513, Republic of Korea;2. Department of Biomedical Engineering, Center for Marine-Integrated Biotechnology (BK21 Plus), Pukyong National University, Busan 48513, Republic of Korea;3. Department of Cogno-Mechatronics Engineering, Pusan National University, Busan 46241, Republic of Korea;4. School of Electronics Engineering, College of IT Engineering, Kyungpook National University, Daegu 41566, Republic of Korea |
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| Abstract: | Organisation of nanoparticles on structurally well-defined templates is a first step towards creating nanomachines. In this respect, nucleic acids are ideal structural templates and a variety of secondary structures realizable from DNA/RNA––e.g., duplexes, hairpins, triplexes, cruciforms, tetraplexes can be exploited to engineer nanoparticle organization at will. We have used oligonucleotides and their analogues such as phosphorothioates and peptide nucleic acids to electrostatically encapsulate cationic-capped gold nanoparticles. This article describes synthesis and characterization of DNA/PNA-gold nanoparticle composites using TEM and UV-Tm techniques. These types of assemblies may have potential for creating nanowires and lithographic circuits. |
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