Fabrication and properties of pH-sensitive nanostructured polyelectrolyte microparticles loaded with insulin |
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| Authors: | N G Balabushevich G A Vikhoreva E V Mikhal’chik N I Larionova |
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| Institution: | 1.Division of Chemical Enzymology, Department of Chemistry,Moscow State University,Moscow,Russia;2.Moscow State Textile University,Moscow,Russia;3.Scientific Research Institute of Physico-Chemical Medicine,Moscow,Russia |
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| Abstract: | Thorough investigation and comparative study were conducted for insulin-loaded microparticles fabricated by consecutive adsorption
of polyanions (dextran sulfate and chitosan sulfate) and polycations (chitosan and protamine) onto protein microaggregates.
The possible regulation of insulin release from the particles by variation in polyelectrolyte pairs, in the number of their
adsorption cycles and in pH of media was demonstrated. For all studied cases the microparticles showed protective action towards
insulin inactivation at acid pH values and protein release at pH > 5, corresponding to human gastro-intestinal conditions. |
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