3,5-Di(hydroxyorganyl)pyrazoles

The reaction of primary-tertiary and secondary-tertiary aliphatic diacetylenic -glycols with hydrazine hydrate leads to the formation of isomeric 3,5-di(hydroxyalkyl)pyrazoles in which the pyrazole ring is present both in the and in the position to the tertiary carbon atom to which the hydroxy group is attached. The structure of the hydrocarbon substituents connected with this atom substantially affects the ratio of the and isomers. The addition of hydrazine hydrate to aliphatic glycols and their monoethers is accompanied by the formation of individual -(hydroxyalkyl)pyrazoles.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 11, pp. 1538–1541, November, 1973.