Chiral separation of pharmacologically active dihydropyrimidinones with carboxymethyl-beta-cyclodextrin |
| |
| Authors: | Lecnik O Schmid M G Kappe C O Gübitz G |
| |
| Affiliation: | Institute of Pharmaceutical Chemistry, Karl-Franzens University, Graz, Austria. |
| |
| Abstract: | We report on the chiral separation of pharmacologically active dihydropyrimidinones by capillary electrophoresis (CE) using carboxymethyl-beta-cyclodextrin as chiral selector. The influence of selector concentration, pH, and the addition of varying amounts of methanol is investigated. Out of 21 compounds investigated, 19 were resolved, 13 with baseline separation. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
