Human neuronal stargazin-like proteins, γ2, γ3 and γ4; an investigation of their specific localization in human brain and their influence on CaV2.1 voltage-dependent calcium channels expressed in Xenopus oocytes. |
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| Authors: | Fraser J Moss Annette C Dolphin Jeffrey J Clare |
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| Affiliation: | (1) Department of Pharmacology, University College London, Gower Street, WC1E 6BT London, UK;(2) Division of Biology, M/C 156-29, California Institute of Technology, 1200 E. California Blvd., 91125 Pasadena, CA, USA;(3) Gene Expression and Protein Biochemistry, GlaxoSmithKline, Medicines Research Center, Gunnels Wood Road, SG1 2NY Stevenage, Herts, UK |
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| Abstract: | Background Stargazin (γ2) and the closely related γ3, and γ4 transmembrane proteins are part of a family of proteins that may act as both neuronal voltage-dependent calcium channel (VDCC) γ subunits and transmembrane α-amino-3-hydroxy-5-methyl-4-isoxazoleproponinc (AMPA) receptor regulatory proteins (TARPs). In this investigation, we examined the distribution patterns of the stargazin-like proteins γ2, γ3, and γ4 in the human central nervous system (CNS). In addition, we investigated whether human γ2 or γ4 could modulate the electrophysiological properties of a neuronal VDCC complex transiently expressed in Xenopus oocytes. |
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