Preparation of a water-soluble fluorinated zinc phthalocyanine and its effect for photodynamic therapy |
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| Authors: | Oda K Ogura S Okura I |
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| Affiliation: | Department of Bioengineering, Tokyo Institute of Technology, Nagatsuta, Yokohama, Japan. |
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| Abstract: | An amphiphilic fluorinated phthalocyanine, zinc tetracarboxyoctafluorophthalocyanine (ZnC4F8Pc) was synthesized and characterized. Its photodynamic efficiency for HeLa cells was compared with hydrophilic zinc octacarboxyphthalocyanine (ZnC8Pc) and hydrophobic zinc hexadecafluorophthalocyanine (ZnF16Pc). ZnC4F8Pc had a remarkable photodynamic effect among the phthalocyanines used. The effect is apparently caused by the fact that ZnC4F8Pc is mainly accumulated in the hydrophobic lipid membrane and is in the photoactive monomer form in HeLa cells. |
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