| Institution: | 1. School of Chemistry and Physics, University of KwaZulu Natal, Durban, South Africa
Department of Chemical Sciences, I. K. Gujral Punjab Technical University, Kapurthala, Punjab, India;2. School of Chemistry and Physics, University of KwaZulu Natal, Durban, South Africa;3. Department of Chemistry, Durban University of Technology, Durban, South Africa;4. Department of Chemical Sciences, I. K. Gujral Punjab Technical University, Kapurthala, Punjab, India;5. Department of Chemistry, Dr B R Ambedkar National Institute of Technology, Jalandhar, Punjab, India |
| Abstract: | A safer, greener, and more effective reaction methodology for the synthesis of dihydroquinazolinones (DHQs) has been developed. The deep eutectic solvent (DES) ZnCl2/urea employed in this study efficiently accelerated the cyclization of 2-aminobenzamide with different aldehydes (aromatic and heteroaromatic) to afford the target scaffolds without the generation of any oxidized product. This method has exhibited remarkable advantages such as quick reaction time, mild reaction conditions, high yield (82%–98%), operational simplicity, and selectivity. The approach was observed to be tolerant to electron-donating and electron-withdrawing functional groups. Green metric parameters (AEf, OE, AE, RME, CE, etc.) determined further aided this greener chemical approach. |
