C‐phosphorylation of 1,2,4‐triazoles with phosphorus(III) halides. Synthesis of 4,5‐dihydrobenzo[e][1,2,4]triazolo[5,1‐c][1,4,2]diazaphosphinine derivatives |
| |
| Authors: | Evgenij V Zarudnitskii Vladimir V Ivanov Alexandr A Yurchenko Alexandr M Pinchuk Andrej A Tolmachev |
| |
| Abstract: | Phosphorylation of 4‐ and 1‐substituted 1,2,4‐triazoles with PCl3, PhPCl2, Ph2PCl, and (Et2N)2 PCl was carried out. A novel phosphorus‐containing condensed heterocyclic system ( 18, 23 ) was constructed by the reactions of 2‐(1H‐1,2,4‐triazol‐1‐yl)‐1‐(4‐chlorophenylcarboxamido)‐5‐trifluoromethylbenzene with PBr3 and PhPBr2. Treatment of the bromophosphonite 18 with an excess of morpholine in the presence of sulfur resulted in a diazaphosphinine ring opening and provided functionalized 1H‐1,2,4‐triazol‐5‐ylphosphonic acid derivatives 21 and 22 . © 2002 Wiley Periodicals, Inc. Heteroatom Chem 13:146–152, 2002; Published online in Wiley Interscience (www.interscience.wiley.com). DOI 10.1002/hc.10010 |
| |
| Keywords: | |
|
|
