Syntheses of some new 1,5‐benzothiazepine derivatives and their ribofuranosides as antimicrobial agents |
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Authors: | Girwar Singh Neeraj Kumar Ashok K Yadav A K Mishra |
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Abstract: | (±)‐cis‐2‐(4‐Methoxyphenyl)‐3‐hydroxy/methoxy‐6‐ethoxy/phenoxy‐2,3‐dihydro‐1,5‐benzothiazepin‐4‐5H/5‐chloroacetyl/5‐(4′‐methylpiperazino‐1′)acetyl]‐ones have been synthesized by the condensation of 2‐amino‐3‐ethoxy/phenoxybenzenethiol with methyl‐(±)‐trans‐3‐(4‐methoxyphenyl)glycidate in xylene. Ribofuranosides, viz. (±)‐cis‐2‐(4‐methoxyphenyl)‐3‐methoxy‐6‐ethoxy/phenoxy‐2,3‐dihydro‐1,5‐benzothiazepin‐4‐5‐(2′,3′,5′‐tri‐O‐benzoyl‐β‐D ‐ribofuranosyl)]‐ones, have been synthesized by the treatment of 3‐methoxy derivatives of 1,5‐benzothiazepines with a derivative, sugar, viz. β‐D ‐ribofuranose‐1‐acetate‐2,3,5‐tribenzoate, in toluene in vacuo. The structures of all the synthesized ribofuranosides and their precursors have been characterized on the basis of elemental analyses and IR, 1H NMR, and 13C NMR spectral data. These compounds were screened for their antimicrobial activity. © 2002 Wiley Periodicals, Inc. Heteroatom Chem 13:620–625, 2002; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/hc.10051 |
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