Nitrogen bridgehead compounds,Part 31 1H and 13C NMR study of tetra- and octahydro-11H-pyrido[2,1-b]quinazolin-11-ones |
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Authors: | Istvn Hermecz Benjamin Podnyi Zoltn Mszros Jzsef Kksi Gyrgy Szsz Gbor Tth |
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Institution: | István Hermecz,Benjamin Podányi,Zoltán Mészáros,József Kökösi,György Szász,Gábor Tóth |
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Abstract: | Conformational analysis of some tetra-and octahydro-11H-pyrido2,1-b]quinazolin-11-ones 1-3 by 1H and 13C nmr revealed that the 9-methyl-6,7,8,9-tetrahydro derivative exists mainly in the conformation containing the methyl group in a quasi-axial orientation. Of the 1,2,3,4,5,6,7,8-octahydro compounds, the 9-methyl derivative 3e contains the methyl group in a quasi-axial position, while that in the 7-methyl and the 8-methyl derivatives 3c,d is in the equatorial position, and the 6-methyl derivative 3b is a mixture of the two conformers. |
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